A critical tryptophan and Ca2+ in activation and catalysis of TPPI, the enzyme deficient in classic late-infantile neuronal ceroid lipofuscinosis.

<h4>Background</h4>Tripeptidyl aminopeptidase I (TPPI) is a crucial lysosomal enzyme that is deficient in the fatal neurodegenerative disorder called classic late-infantile neuronal ceroid lipofuscinosis (LINCL). It is involved in the catabolism of proteins in the lysosomes. Recent X-ray...

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Autores principales: Salomon Kuizon, Kathleen DiMaiuta, Marius Walus, Edmund C Jenkins, Marisol Kuizon, Elizabeth Kida, Adam A Golabek, Daniel O Espinoza, Raju K Pullarkat, Mohammed A Junaid
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
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Acceso en línea:https://doaj.org/article/3a9c7f8f814343f2bb72375efea04d04
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