Association of gastroesophageal reflux disease and laryngeal cancer

Objective: Studies examining the association of reflux disease with the risk of developing laryngeal cancer have both proven and disproven the null hypothesis. Methods: This retrospective case–control study examines the association of reflux in two populations exposed to similar risk factors, includ...

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Autores principales:	Mursalin M. Anis, Mir-Muhammad Razavi, Xiao Xiao, Ahmed M.S. Soliman
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2018
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/3a9d01167ff14d5890aabf32b23f628c
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spelling	oai:doaj.org-article:3a9d01167ff14d5890aabf32b23f628c2021-12-02T12:04:48ZAssociation of gastroesophageal reflux disease and laryngeal cancer2095-881110.1016/j.wjorl.2017.12.011https://doaj.org/article/3a9d01167ff14d5890aabf32b23f628c2018-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881117300185https://doaj.org/toc/2095-8811Objective: Studies examining the association of reflux disease with the risk of developing laryngeal cancer have both proven and disproven the null hypothesis. Methods: This retrospective case–control study examines the association of reflux in two populations exposed to similar risk factors, including tobacco, to the extent that end-organ malignant transformation has occurred. After IRB approval was obtained, a search of our hospital's cancer center's database was performed from 2000 to 2013. A retrospective chart review was then performed and the prevalence of gastroesophageal reflux disease among patients with laryngeal cancer (n = 290) was determined. It was then compared to the prevalence of gastroesophageal reflux disease among patients presenting with lung cancer (n = 2440) during the same time period. A multivariate logistic regression was performed to determine the association of reflux with laryngeal cancer. Results: Taking into consideration tobacco use, there was a strong association between male gender and occurrence of laryngeal cancer as opposed to lung cancer (OR = 3.30; 95% CI 2.53–4.36, P < 0.001). There was a modest association between reflux and laryngeal cancer (OR = 1.65; 95% CI 1.19–2.25, P = 0.003). However, there was no association between reflux and the propensity for carcinoma in specific laryngeal subsites (P = 0.47). Conclusions: In this study examining a heterogeneous population with end-organ malignancy there was a modest association between reflux and laryngeal cancer. Further research is necessary to determine the biologic relevance of this finding. Keywords: Laryngopharyngeal reflux, GERD, Extraesophageal reflux, Laryngeal cancer, Lung cancerMursalin M. AnisMir-Muhammad RazaviXiao XiaoAhmed M.S. SolimanKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 4, Iss 4, Pp 278-281 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 Mursalin M. Anis Mir-Muhammad Razavi Xiao Xiao Ahmed M.S. Soliman Association of gastroesophageal reflux disease and laryngeal cancer
description	Objective: Studies examining the association of reflux disease with the risk of developing laryngeal cancer have both proven and disproven the null hypothesis. Methods: This retrospective case–control study examines the association of reflux in two populations exposed to similar risk factors, including tobacco, to the extent that end-organ malignant transformation has occurred. After IRB approval was obtained, a search of our hospital's cancer center's database was performed from 2000 to 2013. A retrospective chart review was then performed and the prevalence of gastroesophageal reflux disease among patients with laryngeal cancer (n = 290) was determined. It was then compared to the prevalence of gastroesophageal reflux disease among patients presenting with lung cancer (n = 2440) during the same time period. A multivariate logistic regression was performed to determine the association of reflux with laryngeal cancer. Results: Taking into consideration tobacco use, there was a strong association between male gender and occurrence of laryngeal cancer as opposed to lung cancer (OR = 3.30; 95% CI 2.53–4.36, P < 0.001). There was a modest association between reflux and laryngeal cancer (OR = 1.65; 95% CI 1.19–2.25, P = 0.003). However, there was no association between reflux and the propensity for carcinoma in specific laryngeal subsites (P = 0.47). Conclusions: In this study examining a heterogeneous population with end-organ malignancy there was a modest association between reflux and laryngeal cancer. Further research is necessary to determine the biologic relevance of this finding. Keywords: Laryngopharyngeal reflux, GERD, Extraesophageal reflux, Laryngeal cancer, Lung cancer
format	article
author	Mursalin M. Anis Mir-Muhammad Razavi Xiao Xiao Ahmed M.S. Soliman
author_facet	Mursalin M. Anis Mir-Muhammad Razavi Xiao Xiao Ahmed M.S. Soliman
author_sort	Mursalin M. Anis
title	Association of gastroesophageal reflux disease and laryngeal cancer
title_short	Association of gastroesophageal reflux disease and laryngeal cancer
title_full	Association of gastroesophageal reflux disease and laryngeal cancer
title_fullStr	Association of gastroesophageal reflux disease and laryngeal cancer
title_full_unstemmed	Association of gastroesophageal reflux disease and laryngeal cancer
title_sort	association of gastroesophageal reflux disease and laryngeal cancer
publisher	KeAi Communications Co., Ltd.
publishDate	2018
url	https://doaj.org/article/3a9d01167ff14d5890aabf32b23f628c
work_keys_str_mv	AT mursalinmanis associationofgastroesophagealrefluxdiseaseandlaryngealcancer AT mirmuhammadrazavi associationofgastroesophagealrefluxdiseaseandlaryngealcancer AT xiaoxiao associationofgastroesophagealrefluxdiseaseandlaryngealcancer AT ahmedmssoliman associationofgastroesophagealrefluxdiseaseandlaryngealcancer
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Association of gastroesophageal reflux disease and laryngeal cancer

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