Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy

Little is known about how cardiac metabolism remodels following cardiac injury. Here, the authors show that mitochondrial CaMKII plays an important role in remodeling cardiac metabolism after injury and that replacement of mitochondrial creatine kinase improves energetics and protects against advers...

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Autores principales:	Elizabeth D. Luczak, Yuejin Wu, Jonathan M. Granger, Mei-ling A. Joiner, Nicholas R. Wilson, Ashish Gupta, Priya Umapathi, Kevin R. Murphy, Oscar E. Reyes Gaido, Amin Sabet, Eleonora Corradini, Wen-Wei Tseng, Yibin Wang, Albert J. R. Heck, An-Chi Wei, Robert G. Weiss, Mark E. Anderson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a9e4d2ef5934da08394c8adbae0c995
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spelling	oai:doaj.org-article:3a9e4d2ef5934da08394c8adbae0c9952021-12-02T19:09:31ZMitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy10.1038/s41467-020-18165-62041-1723https://doaj.org/article/3a9e4d2ef5934da08394c8adbae0c9952020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18165-6https://doaj.org/toc/2041-1723Little is known about how cardiac metabolism remodels following cardiac injury. Here, the authors show that mitochondrial CaMKII plays an important role in remodeling cardiac metabolism after injury and that replacement of mitochondrial creatine kinase improves energetics and protects against adverse remodeling.Elizabeth D. LuczakYuejin WuJonathan M. GrangerMei-ling A. JoinerNicholas R. WilsonAshish GuptaPriya UmapathiKevin R. MurphyOscar E. Reyes GaidoAmin SabetEleonora CorradiniWen-Wei TsengYibin WangAlbert J. R. HeckAn-Chi WeiRobert G. WeissMark E. AndersonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elizabeth D. Luczak Yuejin Wu Jonathan M. Granger Mei-ling A. Joiner Nicholas R. Wilson Ashish Gupta Priya Umapathi Kevin R. Murphy Oscar E. Reyes Gaido Amin Sabet Eleonora Corradini Wen-Wei Tseng Yibin Wang Albert J. R. Heck An-Chi Wei Robert G. Weiss Mark E. Anderson Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy
description	Little is known about how cardiac metabolism remodels following cardiac injury. Here, the authors show that mitochondrial CaMKII plays an important role in remodeling cardiac metabolism after injury and that replacement of mitochondrial creatine kinase improves energetics and protects against adverse remodeling.
format	article
author	Elizabeth D. Luczak Yuejin Wu Jonathan M. Granger Mei-ling A. Joiner Nicholas R. Wilson Ashish Gupta Priya Umapathi Kevin R. Murphy Oscar E. Reyes Gaido Amin Sabet Eleonora Corradini Wen-Wei Tseng Yibin Wang Albert J. R. Heck An-Chi Wei Robert G. Weiss Mark E. Anderson
author_facet	Elizabeth D. Luczak Yuejin Wu Jonathan M. Granger Mei-ling A. Joiner Nicholas R. Wilson Ashish Gupta Priya Umapathi Kevin R. Murphy Oscar E. Reyes Gaido Amin Sabet Eleonora Corradini Wen-Wei Tseng Yibin Wang Albert J. R. Heck An-Chi Wei Robert G. Weiss Mark E. Anderson
author_sort	Elizabeth D. Luczak
title	Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy
title_short	Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy
title_full	Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy
title_fullStr	Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy
title_full_unstemmed	Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy
title_sort	mitochondrial camkii causes adverse metabolic reprogramming and dilated cardiomyopathy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3a9e4d2ef5934da08394c8adbae0c995
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Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy

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