Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy

Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy

Little is known about how cardiac metabolism remodels following cardiac injury. Here, the authors show that mitochondrial CaMKII plays an important role in remodeling cardiac metabolism after injury and that replacement of mitochondrial creatine kinase improves energetics and protects against advers...

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Bibliographic Details
Main Authors: Elizabeth D. Luczak, Yuejin Wu, Jonathan M. Granger, Mei-ling A. Joiner, Nicholas R. Wilson, Ashish Gupta, Priya Umapathi, Kevin R. Murphy, Oscar E. Reyes Gaido, Amin Sabet, Eleonora Corradini, Wen-Wei Tseng, Yibin Wang, Albert J. R. Heck, An-Chi Wei, Robert G. Weiss, Mark E. Anderson
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
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Online Access:https://doaj.org/article/3a9e4d2ef5934da08394c8adbae0c995
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