Higher Plasma APOC-III Was Associated with a Slower Reduction of β-Amyloid Levels in Cerebrospinal Fluid Among Older Individuals Without Dementia

Higher Plasma APOC-III Was Associated with a Slower Reduction of β-Amyloid Levels in Cerebrospinal Fluid Among Older Individuals Without Dementia

Xiaoyan Zhang On behalf of the Alzheimer’s Disease Neuroimaging InitiativeDepartment of Child Healthcare, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of ChinaCorrespondence: Xiaoyan ZhangThe Sec...

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Autor principal: Zhang X
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
alzheimer’s disease
apolipoprotein c-iii
beta-amyloid
tau proteins
longitudinal study.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/3a9e6f0f3b864bceb6b276c204ef6676
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spelling oai:doaj.org-article:3a9e6f0f3b864bceb6b276c204ef66762021-12-02T09:29:44ZHigher Plasma APOC-III Was Associated with a Slower Reduction of β-Amyloid Levels in Cerebrospinal Fluid Among Older Individuals Without Dementia1178-2021https://doaj.org/article/3a9e6f0f3b864bceb6b276c204ef66762020-05-01T00:00:00Zhttps://www.dovepress.com/higher-plasma-apoc-iii-was-associated-with-a-slower-reduction-of-beta--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xiaoyan Zhang On behalf of the Alzheimer’s Disease Neuroimaging InitiativeDepartment of Child Healthcare, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of ChinaCorrespondence: Xiaoyan ZhangThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou 325027, Zhejiang Province, People’s Republic of ChinaEmail 18815001229@163.comPurpose: Although emerging evidence has suggested that apolipoprotein C-III (APOC-III) is involved in the pathogenesis of Alzheimer’s disease (AD), the association of APOC-III with longitudinal changes in cerebrospinal fluid (CSF) AD pathologies (β-amyloid (Aβ 42) and tau proteins) is not clear. In the present study, we aimed to examine whether plasma APOC-III levels are associated with longitudinal changes in CSF Aβ 42, total-tau (t-tau), and phosphorylated-tau (p-tau) levels among older individuals without dementia.Patients and Methods: Linear mixed models were fitted with plasma APOC-III used as a predictor for longitudinal changes in CSF AD biomarkers over a 7-year period. Data were obtained from the Alzheimer’s Disease Neuroimaging Initiative database, and 195 older individuals without dementia (47 subjects with normal cognition (NC) and 148 subjects with mild cognitive impairment (MCI)) with baseline plasma APOC-III measurements were included.Results: Among older individuals without dementia, we found that the tertiles of plasma APOC-III were associated with changes in CSF Aβ 42, but not t-tau or p-tau. Specifically, the CSF Aβ 42 reduction for individuals in the highest plasma APOC-III tertile was significantly slower compared with those in the middle tertile, whereas no other pairwise difference was found to be statistically significant.Conclusion: Among older individuals without dementia, higher plasma APOC-III levels were associated with slower declines in CSF Aβ 42.Keywords: Alzheimer’s disease, apolipoprotein C-III, beta-amyloid, tau proteins, longitudinal studyZhang XDove Medical Pressarticlealzheimer’s diseaseapolipoprotein c-iiibeta-amyloidtau proteinslongitudinal study.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1139-1144 (2020)
institution DOAJ
collection DOAJ
language EN
topic alzheimer’s disease
apolipoprotein c-iii
beta-amyloid
tau proteins
longitudinal study.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle alzheimer’s disease
apolipoprotein c-iii
beta-amyloid
tau proteins
longitudinal study.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Zhang X
Higher Plasma APOC-III Was Associated with a Slower Reduction of β-Amyloid Levels in Cerebrospinal Fluid Among Older Individuals Without Dementia
description Xiaoyan Zhang On behalf of the Alzheimer’s Disease Neuroimaging InitiativeDepartment of Child Healthcare, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of ChinaCorrespondence: Xiaoyan ZhangThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou 325027, Zhejiang Province, People’s Republic of ChinaEmail 18815001229@163.comPurpose: Although emerging evidence has suggested that apolipoprotein C-III (APOC-III) is involved in the pathogenesis of Alzheimer’s disease (AD), the association of APOC-III with longitudinal changes in cerebrospinal fluid (CSF) AD pathologies (β-amyloid (Aβ 42) and tau proteins) is not clear. In the present study, we aimed to examine whether plasma APOC-III levels are associated with longitudinal changes in CSF Aβ 42, total-tau (t-tau), and phosphorylated-tau (p-tau) levels among older individuals without dementia.Patients and Methods: Linear mixed models were fitted with plasma APOC-III used as a predictor for longitudinal changes in CSF AD biomarkers over a 7-year period. Data were obtained from the Alzheimer’s Disease Neuroimaging Initiative database, and 195 older individuals without dementia (47 subjects with normal cognition (NC) and 148 subjects with mild cognitive impairment (MCI)) with baseline plasma APOC-III measurements were included.Results: Among older individuals without dementia, we found that the tertiles of plasma APOC-III were associated with changes in CSF Aβ 42, but not t-tau or p-tau. Specifically, the CSF Aβ 42 reduction for individuals in the highest plasma APOC-III tertile was significantly slower compared with those in the middle tertile, whereas no other pairwise difference was found to be statistically significant.Conclusion: Among older individuals without dementia, higher plasma APOC-III levels were associated with slower declines in CSF Aβ 42.Keywords: Alzheimer’s disease, apolipoprotein C-III, beta-amyloid, tau proteins, longitudinal study
format article
author Zhang X
author_facet Zhang X
author_sort Zhang X
title Higher Plasma APOC-III Was Associated with a Slower Reduction of β-Amyloid Levels in Cerebrospinal Fluid Among Older Individuals Without Dementia
title_short Higher Plasma APOC-III Was Associated with a Slower Reduction of β-Amyloid Levels in Cerebrospinal Fluid Among Older Individuals Without Dementia
title_full Higher Plasma APOC-III Was Associated with a Slower Reduction of β-Amyloid Levels in Cerebrospinal Fluid Among Older Individuals Without Dementia
title_fullStr Higher Plasma APOC-III Was Associated with a Slower Reduction of β-Amyloid Levels in Cerebrospinal Fluid Among Older Individuals Without Dementia
title_full_unstemmed Higher Plasma APOC-III Was Associated with a Slower Reduction of β-Amyloid Levels in Cerebrospinal Fluid Among Older Individuals Without Dementia
title_sort higher plasma apoc-iii was associated with a slower reduction of β-amyloid levels in cerebrospinal fluid among older individuals without dementia
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/3a9e6f0f3b864bceb6b276c204ef6676
work_keys_str_mv AT zhangx higherplasmaapociiiwasassociatedwithaslowerreductionofbetaamyloidlevelsincerebrospinalfluidamongolderindividualswithoutdementia
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