Preparation of Fe3O4 magnetic nanoparticles coated with gallic acid for drug delivery

Dena Dorniani,1 Mohd Zobir Bin Hussein,1,2 Aminu Umar Kura,3 Sharida Fakurazi,3 Abdul Halim Shaari,4 Zalinah Ahmad51Chemistry Department, Faculty of Science, 2Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology, 3Vaccines and Immunotherapeutics Laboratory, 4Physics Dep...

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Autores principales:	Dorniani D, Bin Hussein MZ, Kura AU, Fakurazi S, Shaari AH, Ahmad Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3a9f60cabeb740198ee08bec51d84a55
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spelling	oai:doaj.org-article:3a9f60cabeb740198ee08bec51d84a552021-12-02T11:01:34ZPreparation of Fe3O4 magnetic nanoparticles coated with gallic acid for drug delivery1176-91141178-2013https://doaj.org/article/3a9f60cabeb740198ee08bec51d84a552012-11-01T00:00:00Zhttp://www.dovepress.com/preparation-of-fe3o4-magnetic-nanoparticles-coated-with-gallic-acid-fo-a11506https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Dena Dorniani,1 Mohd Zobir Bin Hussein,1,2 Aminu Umar Kura,3 Sharida Fakurazi,3 Abdul Halim Shaari,4 Zalinah Ahmad51Chemistry Department, Faculty of Science, 2Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology, 3Vaccines and Immunotherapeutics Laboratory, 4Physics Department, Faculty of Science, 5Chemical Pathology Unit, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, MalaysiaBackground and methods: Magnetic iron oxide nanoparticles were prepared using a sonochemical method under atmospheric conditions at a Fe2+ to Fe3+ molar ratio of 1:2. The iron oxide nanoparticles were subsequently coated with chitosan and gallic acid to produce a core-shell structure.Results: X-ray diffraction demonstrated that the magnetic nanoparticles were pure Fe3O4 with a cubic inverse spinel structure. Transmission electron microscopy showed that the Fe3O4 nanoparticles were of spherical shape with a mean diameter of 11 nm, compared with 13 nm for the iron oxide-chitosan-gallic acid (FCG) nanocarriers.Conclusion: The magnetic nanocarrier enhanced the thermal stability of the drug, gallic acid. Release of the active drug from the FCG nanocarrier was found to occur in a controlled manner. The gallic acid and FCG nanoparticles were not toxic in a normal human fibroblast (3T3) line, and anticancer activity was higher in HT29 than MCF7 cell lines.Keywords: magnetic nanoparticles, chitosan, superparamagnetic, controlled-release, gallic acid, drug deliveryDorniani DBin Hussein MZKura AUFakurazi SShaari AHAhmad ZDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 5745-5756 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Dorniani D Bin Hussein MZ Kura AU Fakurazi S Shaari AH Ahmad Z Preparation of Fe3O4 magnetic nanoparticles coated with gallic acid for drug delivery
description	Dena Dorniani,1 Mohd Zobir Bin Hussein,1,2 Aminu Umar Kura,3 Sharida Fakurazi,3 Abdul Halim Shaari,4 Zalinah Ahmad51Chemistry Department, Faculty of Science, 2Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology, 3Vaccines and Immunotherapeutics Laboratory, 4Physics Department, Faculty of Science, 5Chemical Pathology Unit, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, MalaysiaBackground and methods: Magnetic iron oxide nanoparticles were prepared using a sonochemical method under atmospheric conditions at a Fe2+ to Fe3+ molar ratio of 1:2. The iron oxide nanoparticles were subsequently coated with chitosan and gallic acid to produce a core-shell structure.Results: X-ray diffraction demonstrated that the magnetic nanoparticles were pure Fe3O4 with a cubic inverse spinel structure. Transmission electron microscopy showed that the Fe3O4 nanoparticles were of spherical shape with a mean diameter of 11 nm, compared with 13 nm for the iron oxide-chitosan-gallic acid (FCG) nanocarriers.Conclusion: The magnetic nanocarrier enhanced the thermal stability of the drug, gallic acid. Release of the active drug from the FCG nanocarrier was found to occur in a controlled manner. The gallic acid and FCG nanoparticles were not toxic in a normal human fibroblast (3T3) line, and anticancer activity was higher in HT29 than MCF7 cell lines.Keywords: magnetic nanoparticles, chitosan, superparamagnetic, controlled-release, gallic acid, drug delivery
format	article
author	Dorniani D Bin Hussein MZ Kura AU Fakurazi S Shaari AH Ahmad Z
author_facet	Dorniani D Bin Hussein MZ Kura AU Fakurazi S Shaari AH Ahmad Z
author_sort	Dorniani D
title	Preparation of Fe3O4 magnetic nanoparticles coated with gallic acid for drug delivery
title_short	Preparation of Fe3O4 magnetic nanoparticles coated with gallic acid for drug delivery
title_full	Preparation of Fe3O4 magnetic nanoparticles coated with gallic acid for drug delivery
title_fullStr	Preparation of Fe3O4 magnetic nanoparticles coated with gallic acid for drug delivery
title_full_unstemmed	Preparation of Fe3O4 magnetic nanoparticles coated with gallic acid for drug delivery
title_sort	preparation of fe3o4 magnetic nanoparticles coated with gallic acid for drug delivery
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/3a9f60cabeb740198ee08bec51d84a55
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Preparation of Fe3O4 magnetic nanoparticles coated with gallic acid for drug delivery

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