To achieve 95-95-95 targets we must reach men and youth: High level of knowledge of HIV status, ART coverage, and viral suppression in the Botswana Combination Prevention Project through universal test and treat approach.
<h4>Background</h4>Increasing HIV treatment coverage is crucial to reducing population-level HIV incidence.<h4>Methods</h4>The Botswana Combination Prevention Project (BCPP) was a community randomized trial examining the impact of multiple prevention interventions on populati...
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2021
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oai:doaj.org-article:3aa07e96339f4258ab69e6c3db81ea422021-12-02T20:15:06ZTo achieve 95-95-95 targets we must reach men and youth: High level of knowledge of HIV status, ART coverage, and viral suppression in the Botswana Combination Prevention Project through universal test and treat approach.1932-620310.1371/journal.pone.0255227https://doaj.org/article/3aa07e96339f4258ab69e6c3db81ea422021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255227https://doaj.org/toc/1932-6203<h4>Background</h4>Increasing HIV treatment coverage is crucial to reducing population-level HIV incidence.<h4>Methods</h4>The Botswana Combination Prevention Project (BCPP) was a community randomized trial examining the impact of multiple prevention interventions on population-level HIV incidence and was conducted from October 2013 through June 2017. Home and mobile campaigns offered HIV testing to all individuals ≥ age 16. All identified HIV-positive persons who were not on antiretroviral therapy (ART) were referred to treatment and tracked to determine linkage to care, ART status, retention in treatment, and viral suppression.<h4>Results</h4>Of an estimated total of 14,270 people living with HIV (PLHIV) residing in the 15 intervention communities, BCPP identified 13,328 HIV-positive persons (93%). At study start, 10,703 (80%) of estimated PLHIV knew their status; 2,625 (20%) learned their status during BCPP, a 25% increase with the greatest increases occurring among men (37%) and youth (77%). At study start, 9,258 (65%) of estimated PLHIV were on ART. An additional 3,001 persons started ART through the study. By study end, 12,259 had initiated and were retained on ART, increasing coverage to 93%. A greater increase in ART coverage was achieved among men (40%) compared to women (29%). Of the 11,954 persons who had viral load (VL) test results, 11,687 (98%) were virally suppressed (HIV-1 RNA ≤400 copies/mL). Overall, 82% had documented VL suppression by study end.<h4>Conclusions</h4>Knowledge of HIV-positive status and ART coverage increased towards 95-95 targets with universal testing, linkage interventions, and ART. The increases in HIV testing and ART use among men and youth were essential to reaching these targets.<h4>Clinical trial number</h4>NCT01965470.Refeletswe LebelonyanePamela BachanasLisa BlockFaith UsseryMary Grace AlwanoTafireyi MarukutiraShenaaz El HalabiMichelle RolandWilliam AbramsGene UsseryJames A MillerShahin LockmanTendani GaolatheMolly Pretorius HolmeShannon HaderLisa A MillsKathleen WirthNaomi BockJanet MoorePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255227 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Refeletswe Lebelonyane Pamela Bachanas Lisa Block Faith Ussery Mary Grace Alwano Tafireyi Marukutira Shenaaz El Halabi Michelle Roland William Abrams Gene Ussery James A Miller Shahin Lockman Tendani Gaolathe Molly Pretorius Holme Shannon Hader Lisa A Mills Kathleen Wirth Naomi Bock Janet Moore To achieve 95-95-95 targets we must reach men and youth: High level of knowledge of HIV status, ART coverage, and viral suppression in the Botswana Combination Prevention Project through universal test and treat approach. |
| description |
<h4>Background</h4>Increasing HIV treatment coverage is crucial to reducing population-level HIV incidence.<h4>Methods</h4>The Botswana Combination Prevention Project (BCPP) was a community randomized trial examining the impact of multiple prevention interventions on population-level HIV incidence and was conducted from October 2013 through June 2017. Home and mobile campaigns offered HIV testing to all individuals ≥ age 16. All identified HIV-positive persons who were not on antiretroviral therapy (ART) were referred to treatment and tracked to determine linkage to care, ART status, retention in treatment, and viral suppression.<h4>Results</h4>Of an estimated total of 14,270 people living with HIV (PLHIV) residing in the 15 intervention communities, BCPP identified 13,328 HIV-positive persons (93%). At study start, 10,703 (80%) of estimated PLHIV knew their status; 2,625 (20%) learned their status during BCPP, a 25% increase with the greatest increases occurring among men (37%) and youth (77%). At study start, 9,258 (65%) of estimated PLHIV were on ART. An additional 3,001 persons started ART through the study. By study end, 12,259 had initiated and were retained on ART, increasing coverage to 93%. A greater increase in ART coverage was achieved among men (40%) compared to women (29%). Of the 11,954 persons who had viral load (VL) test results, 11,687 (98%) were virally suppressed (HIV-1 RNA ≤400 copies/mL). Overall, 82% had documented VL suppression by study end.<h4>Conclusions</h4>Knowledge of HIV-positive status and ART coverage increased towards 95-95 targets with universal testing, linkage interventions, and ART. The increases in HIV testing and ART use among men and youth were essential to reaching these targets.<h4>Clinical trial number</h4>NCT01965470. |
| format |
article |
| author |
Refeletswe Lebelonyane Pamela Bachanas Lisa Block Faith Ussery Mary Grace Alwano Tafireyi Marukutira Shenaaz El Halabi Michelle Roland William Abrams Gene Ussery James A Miller Shahin Lockman Tendani Gaolathe Molly Pretorius Holme Shannon Hader Lisa A Mills Kathleen Wirth Naomi Bock Janet Moore |
| author_facet |
Refeletswe Lebelonyane Pamela Bachanas Lisa Block Faith Ussery Mary Grace Alwano Tafireyi Marukutira Shenaaz El Halabi Michelle Roland William Abrams Gene Ussery James A Miller Shahin Lockman Tendani Gaolathe Molly Pretorius Holme Shannon Hader Lisa A Mills Kathleen Wirth Naomi Bock Janet Moore |
| author_sort |
Refeletswe Lebelonyane |
| title |
To achieve 95-95-95 targets we must reach men and youth: High level of knowledge of HIV status, ART coverage, and viral suppression in the Botswana Combination Prevention Project through universal test and treat approach. |
| title_short |
To achieve 95-95-95 targets we must reach men and youth: High level of knowledge of HIV status, ART coverage, and viral suppression in the Botswana Combination Prevention Project through universal test and treat approach. |
| title_full |
To achieve 95-95-95 targets we must reach men and youth: High level of knowledge of HIV status, ART coverage, and viral suppression in the Botswana Combination Prevention Project through universal test and treat approach. |
| title_fullStr |
To achieve 95-95-95 targets we must reach men and youth: High level of knowledge of HIV status, ART coverage, and viral suppression in the Botswana Combination Prevention Project through universal test and treat approach. |
| title_full_unstemmed |
To achieve 95-95-95 targets we must reach men and youth: High level of knowledge of HIV status, ART coverage, and viral suppression in the Botswana Combination Prevention Project through universal test and treat approach. |
| title_sort |
to achieve 95-95-95 targets we must reach men and youth: high level of knowledge of hiv status, art coverage, and viral suppression in the botswana combination prevention project through universal test and treat approach. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/3aa07e96339f4258ab69e6c3db81ea42 |
| work_keys_str_mv |
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