The effect of three-monthly albendazole treatment on malarial parasitemia and allergy: a household-based cluster-randomized, double-blind, placebo-controlled trial.
<h4>Background</h4>Helminth infections are proposed to have immunomodulatory activities affecting health outcomes either detrimentally or beneficially. We evaluated the effects of albendazole treatment, every three months for 21 months, on STH, malarial parasitemia and allergy.<h4>...
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oai:doaj.org-article:3aa361fac020437fa193fb261b03b2de2021-11-18T07:53:00ZThe effect of three-monthly albendazole treatment on malarial parasitemia and allergy: a household-based cluster-randomized, double-blind, placebo-controlled trial.1932-620310.1371/journal.pone.0057899https://doaj.org/article/3aa361fac020437fa193fb261b03b2de2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23526959/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Helminth infections are proposed to have immunomodulatory activities affecting health outcomes either detrimentally or beneficially. We evaluated the effects of albendazole treatment, every three months for 21 months, on STH, malarial parasitemia and allergy.<h4>Methods and findings</h4>A household-based cluster-randomized, double-blind, placebo-controlled trial was conducted in an area in Indonesia endemic for STH. Using computer-aided block randomization, 481 households (2022 subjects) and 473 households (1982 subjects) were assigned to receive placebo and albendazole, respectively, every three months. The treatment code was concealed from trial investigators and participants. Malarial parasitemia and malaria-like symptoms were assessed in participants older than four years of age while skin prick test (SPT) to allergens as well as reported symptoms of allergy in children aged 5-15 years. The general impact of treatment on STH prevalence and body mass index (BMI) was evaluated. Primary outcomes were prevalence of malarial parasitemia and SPT to any allergen. Analysis was by intention to treat. At 9 and 21 months post-treatment 80.8% and 80.1% of the study subjects were retained, respectively. The intensive treatment regiment resulted in a reduction in the prevalence of STH by 48% in albendazole and 9% in placebo group. Albendazole treatment led to a transient increase in malarial parasitemia at 6 months post treatment (OR 4.16(1.35-12.80)) and no statistically significant increase in SPT reactivity (OR 1.18(0.74-1.86) at 9 months or 1.37 (0.93-2.01) 21 months). No effect of anthelminthic treatment was found on BMI, reported malaria-like- and allergy symptoms. No adverse effects were reported.<h4>Conclusions</h4>The study indicates that intensive community treatment of 3 monthly albendazole administration for 21 months over two years leads to a reduction in STH. This degree of reduction appears safe without any increased risk of malaria or allergies.<h4>Trial registration</h4>Controlled-Trials.com ISRCTN83830814.Aprilianto E WiriaFirdaus HamidLinda J WammesMaria M M KaisarLinda MayMargaretta A PrasetyaniSitti WahyuniYenny DjuardiIwan AriawanHeri WibowoBertrand LellRobert SauerweinGary T BriceInge SutantoLisette van LieshoutAnton J M de CraenRonald van ReeJaco J VerweijRoula TsonakaJeanine J Houwing-DuistermaatAdrian J F LutyErliyani SartonoTaniawati SupaliMaria YazdanbakhshPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e57899 (2013) |
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Medicine R Science Q Aprilianto E Wiria Firdaus Hamid Linda J Wammes Maria M M Kaisar Linda May Margaretta A Prasetyani Sitti Wahyuni Yenny Djuardi Iwan Ariawan Heri Wibowo Bertrand Lell Robert Sauerwein Gary T Brice Inge Sutanto Lisette van Lieshout Anton J M de Craen Ronald van Ree Jaco J Verweij Roula Tsonaka Jeanine J Houwing-Duistermaat Adrian J F Luty Erliyani Sartono Taniawati Supali Maria Yazdanbakhsh The effect of three-monthly albendazole treatment on malarial parasitemia and allergy: a household-based cluster-randomized, double-blind, placebo-controlled trial. |
| description |
<h4>Background</h4>Helminth infections are proposed to have immunomodulatory activities affecting health outcomes either detrimentally or beneficially. We evaluated the effects of albendazole treatment, every three months for 21 months, on STH, malarial parasitemia and allergy.<h4>Methods and findings</h4>A household-based cluster-randomized, double-blind, placebo-controlled trial was conducted in an area in Indonesia endemic for STH. Using computer-aided block randomization, 481 households (2022 subjects) and 473 households (1982 subjects) were assigned to receive placebo and albendazole, respectively, every three months. The treatment code was concealed from trial investigators and participants. Malarial parasitemia and malaria-like symptoms were assessed in participants older than four years of age while skin prick test (SPT) to allergens as well as reported symptoms of allergy in children aged 5-15 years. The general impact of treatment on STH prevalence and body mass index (BMI) was evaluated. Primary outcomes were prevalence of malarial parasitemia and SPT to any allergen. Analysis was by intention to treat. At 9 and 21 months post-treatment 80.8% and 80.1% of the study subjects were retained, respectively. The intensive treatment regiment resulted in a reduction in the prevalence of STH by 48% in albendazole and 9% in placebo group. Albendazole treatment led to a transient increase in malarial parasitemia at 6 months post treatment (OR 4.16(1.35-12.80)) and no statistically significant increase in SPT reactivity (OR 1.18(0.74-1.86) at 9 months or 1.37 (0.93-2.01) 21 months). No effect of anthelminthic treatment was found on BMI, reported malaria-like- and allergy symptoms. No adverse effects were reported.<h4>Conclusions</h4>The study indicates that intensive community treatment of 3 monthly albendazole administration for 21 months over two years leads to a reduction in STH. This degree of reduction appears safe without any increased risk of malaria or allergies.<h4>Trial registration</h4>Controlled-Trials.com ISRCTN83830814. |
| format |
article |
| author |
Aprilianto E Wiria Firdaus Hamid Linda J Wammes Maria M M Kaisar Linda May Margaretta A Prasetyani Sitti Wahyuni Yenny Djuardi Iwan Ariawan Heri Wibowo Bertrand Lell Robert Sauerwein Gary T Brice Inge Sutanto Lisette van Lieshout Anton J M de Craen Ronald van Ree Jaco J Verweij Roula Tsonaka Jeanine J Houwing-Duistermaat Adrian J F Luty Erliyani Sartono Taniawati Supali Maria Yazdanbakhsh |
| author_facet |
Aprilianto E Wiria Firdaus Hamid Linda J Wammes Maria M M Kaisar Linda May Margaretta A Prasetyani Sitti Wahyuni Yenny Djuardi Iwan Ariawan Heri Wibowo Bertrand Lell Robert Sauerwein Gary T Brice Inge Sutanto Lisette van Lieshout Anton J M de Craen Ronald van Ree Jaco J Verweij Roula Tsonaka Jeanine J Houwing-Duistermaat Adrian J F Luty Erliyani Sartono Taniawati Supali Maria Yazdanbakhsh |
| author_sort |
Aprilianto E Wiria |
| title |
The effect of three-monthly albendazole treatment on malarial parasitemia and allergy: a household-based cluster-randomized, double-blind, placebo-controlled trial. |
| title_short |
The effect of three-monthly albendazole treatment on malarial parasitemia and allergy: a household-based cluster-randomized, double-blind, placebo-controlled trial. |
| title_full |
The effect of three-monthly albendazole treatment on malarial parasitemia and allergy: a household-based cluster-randomized, double-blind, placebo-controlled trial. |
| title_fullStr |
The effect of three-monthly albendazole treatment on malarial parasitemia and allergy: a household-based cluster-randomized, double-blind, placebo-controlled trial. |
| title_full_unstemmed |
The effect of three-monthly albendazole treatment on malarial parasitemia and allergy: a household-based cluster-randomized, double-blind, placebo-controlled trial. |
| title_sort |
effect of three-monthly albendazole treatment on malarial parasitemia and allergy: a household-based cluster-randomized, double-blind, placebo-controlled trial. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/3aa361fac020437fa193fb261b03b2de |
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