Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa

Using cervical explant models and cervical tissue from ART-suppressed HIV+ women, the authors here show that resident memory T cells (TRM) in the cervical mucosa are preferentially infected and harbor more viral DNA, RNA and protein than non-TRM, suggesting that TRM may serve as viral reservoir in t...

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Autores principales:	Jon Cantero-Pérez, Judith Grau-Expósito, Carla Serra-Peinado, Daniela A. Rosero, Laura Luque-Ballesteros, Antonio Astorga-Gamaza, Josep Castellví, Tamara Sanhueza, Gustavo Tapia, Belen Lloveras, Marco A. Fernández, Julia G. Prado, Josep M. Solé-Sedeno, Antoni Tarrats, Carla Lecumberri, Laura Mañalich-Barrachina, Cristina Centeno-Mediavilla, Vicenç Falcó, Maria J. Buzon, Meritxell Genescà
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3aa422cb216c4cfc82538033c88d2d8f
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spelling	oai:doaj.org-article:3aa422cb216c4cfc82538033c88d2d8f2021-12-02T14:39:36ZResident memory T cells are a cellular reservoir for HIV in the cervical mucosa10.1038/s41467-019-12732-22041-1723https://doaj.org/article/3aa422cb216c4cfc82538033c88d2d8f2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12732-2https://doaj.org/toc/2041-1723Using cervical explant models and cervical tissue from ART-suppressed HIV+ women, the authors here show that resident memory T cells (TRM) in the cervical mucosa are preferentially infected and harbor more viral DNA, RNA and protein than non-TRM, suggesting that TRM may serve as viral reservoir in the cervical mucosa.Jon Cantero-PérezJudith Grau-ExpósitoCarla Serra-PeinadoDaniela A. RoseroLaura Luque-BallesterosAntonio Astorga-GamazaJosep CastellvíTamara SanhuezaGustavo TapiaBelen LloverasMarco A. FernándezJulia G. PradoJosep M. Solé-SedenoAntoni TarratsCarla LecumberriLaura Mañalich-BarrachinaCristina Centeno-MediavillaVicenç FalcóMaria J. BuzonMeritxell GenescàNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jon Cantero-Pérez Judith Grau-Expósito Carla Serra-Peinado Daniela A. Rosero Laura Luque-Ballesteros Antonio Astorga-Gamaza Josep Castellví Tamara Sanhueza Gustavo Tapia Belen Lloveras Marco A. Fernández Julia G. Prado Josep M. Solé-Sedeno Antoni Tarrats Carla Lecumberri Laura Mañalich-Barrachina Cristina Centeno-Mediavilla Vicenç Falcó Maria J. Buzon Meritxell Genescà Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa
description	Using cervical explant models and cervical tissue from ART-suppressed HIV+ women, the authors here show that resident memory T cells (TRM) in the cervical mucosa are preferentially infected and harbor more viral DNA, RNA and protein than non-TRM, suggesting that TRM may serve as viral reservoir in the cervical mucosa.
format	article
author	Jon Cantero-Pérez Judith Grau-Expósito Carla Serra-Peinado Daniela A. Rosero Laura Luque-Ballesteros Antonio Astorga-Gamaza Josep Castellví Tamara Sanhueza Gustavo Tapia Belen Lloveras Marco A. Fernández Julia G. Prado Josep M. Solé-Sedeno Antoni Tarrats Carla Lecumberri Laura Mañalich-Barrachina Cristina Centeno-Mediavilla Vicenç Falcó Maria J. Buzon Meritxell Genescà
author_facet	Jon Cantero-Pérez Judith Grau-Expósito Carla Serra-Peinado Daniela A. Rosero Laura Luque-Ballesteros Antonio Astorga-Gamaza Josep Castellví Tamara Sanhueza Gustavo Tapia Belen Lloveras Marco A. Fernández Julia G. Prado Josep M. Solé-Sedeno Antoni Tarrats Carla Lecumberri Laura Mañalich-Barrachina Cristina Centeno-Mediavilla Vicenç Falcó Maria J. Buzon Meritxell Genescà
author_sort	Jon Cantero-Pérez
title	Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa
title_short	Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa
title_full	Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa
title_fullStr	Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa
title_full_unstemmed	Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa
title_sort	resident memory t cells are a cellular reservoir for hiv in the cervical mucosa
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3aa422cb216c4cfc82538033c88d2d8f
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Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa

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