Efficacy and Safety of Very Early Mobilization in Patients with Acute Stroke: A Systematic Review and Meta-analysis
Abstract Whether very early mobilization (VEM) improves outcomes in stroke patients and reduces immobilization-related complications (IRCs) is currently unknown. The objective of this systematic review and meta-analysis was to evaluate the efficacy and safety of VEM in acute stroke patients followin...
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Nature Portfolio
2017
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oai:doaj.org-article:3aa52903c10e457faf558dd4a2873fc72021-12-02T11:52:37ZEfficacy and Safety of Very Early Mobilization in Patients with Acute Stroke: A Systematic Review and Meta-analysis10.1038/s41598-017-06871-z2045-2322https://doaj.org/article/3aa52903c10e457faf558dd4a2873fc72017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06871-zhttps://doaj.org/toc/2045-2322Abstract Whether very early mobilization (VEM) improves outcomes in stroke patients and reduces immobilization-related complications (IRCs) is currently unknown. The objective of this systematic review and meta-analysis was to evaluate the efficacy and safety of VEM in acute stroke patients following admission. Medline, Embase, and Cochrane Central Register of Controlled Trials databases were searched for randomized controlled trials (RCTs) that examined the efficacy or safety of VEM in patients with acute stroke. VEM was defined as out of bed activity commencing within 24 or 48 hours after the onset of stroke. A total of 9 RCTs with 2,803 participants were included. Upon analysis, VEM was not associated with favorable functional outcomes (modified Ranking Scale: 0–2) at 3 months [relative risk (RR): 0.96; 95% confidence interval (CI): 0.86–1.06]; VEM did not reduce the risk of IRCs during follow up. With respect to safety outcomes, VEM was not associated with a higher risk of death (RR: 1.04; 95% CI: 0.52–2.09) and did not increase the risk of neurological deterioration or incidence of falls with injury. In conclusion, pooled data from RCTs concluded that VEM is not associated with beneficial effects when carried out in patients 24 or 48 hours after the onset of a stroke.Tao XuXinyuan YuShu OuXi LiuJinxian YuanYangmei ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
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Medicine R Science Q Tao Xu Xinyuan Yu Shu Ou Xi Liu Jinxian Yuan Yangmei Chen Efficacy and Safety of Very Early Mobilization in Patients with Acute Stroke: A Systematic Review and Meta-analysis |
| description |
Abstract Whether very early mobilization (VEM) improves outcomes in stroke patients and reduces immobilization-related complications (IRCs) is currently unknown. The objective of this systematic review and meta-analysis was to evaluate the efficacy and safety of VEM in acute stroke patients following admission. Medline, Embase, and Cochrane Central Register of Controlled Trials databases were searched for randomized controlled trials (RCTs) that examined the efficacy or safety of VEM in patients with acute stroke. VEM was defined as out of bed activity commencing within 24 or 48 hours after the onset of stroke. A total of 9 RCTs with 2,803 participants were included. Upon analysis, VEM was not associated with favorable functional outcomes (modified Ranking Scale: 0–2) at 3 months [relative risk (RR): 0.96; 95% confidence interval (CI): 0.86–1.06]; VEM did not reduce the risk of IRCs during follow up. With respect to safety outcomes, VEM was not associated with a higher risk of death (RR: 1.04; 95% CI: 0.52–2.09) and did not increase the risk of neurological deterioration or incidence of falls with injury. In conclusion, pooled data from RCTs concluded that VEM is not associated with beneficial effects when carried out in patients 24 or 48 hours after the onset of a stroke. |
| format |
article |
| author |
Tao Xu Xinyuan Yu Shu Ou Xi Liu Jinxian Yuan Yangmei Chen |
| author_facet |
Tao Xu Xinyuan Yu Shu Ou Xi Liu Jinxian Yuan Yangmei Chen |
| author_sort |
Tao Xu |
| title |
Efficacy and Safety of Very Early Mobilization in Patients with Acute Stroke: A Systematic Review and Meta-analysis |
| title_short |
Efficacy and Safety of Very Early Mobilization in Patients with Acute Stroke: A Systematic Review and Meta-analysis |
| title_full |
Efficacy and Safety of Very Early Mobilization in Patients with Acute Stroke: A Systematic Review and Meta-analysis |
| title_fullStr |
Efficacy and Safety of Very Early Mobilization in Patients with Acute Stroke: A Systematic Review and Meta-analysis |
| title_full_unstemmed |
Efficacy and Safety of Very Early Mobilization in Patients with Acute Stroke: A Systematic Review and Meta-analysis |
| title_sort |
efficacy and safety of very early mobilization in patients with acute stroke: a systematic review and meta-analysis |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/3aa52903c10e457faf558dd4a2873fc7 |
| work_keys_str_mv |
AT taoxu efficacyandsafetyofveryearlymobilizationinpatientswithacutestrokeasystematicreviewandmetaanalysis AT xinyuanyu efficacyandsafetyofveryearlymobilizationinpatientswithacutestrokeasystematicreviewandmetaanalysis AT shuou efficacyandsafetyofveryearlymobilizationinpatientswithacutestrokeasystematicreviewandmetaanalysis AT xiliu efficacyandsafetyofveryearlymobilizationinpatientswithacutestrokeasystematicreviewandmetaanalysis AT jinxianyuan efficacyandsafetyofveryearlymobilizationinpatientswithacutestrokeasystematicreviewandmetaanalysis AT yangmeichen efficacyandsafetyofveryearlymobilizationinpatientswithacutestrokeasystematicreviewandmetaanalysis |
| _version_ |
1718394978057584640 |