DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells

PD-L1 is upregulated in many cancers due to exogenous cellular stress. Here the authors show that PD-L1 is upregulated in response to DNA double strand breaks via STAT and IRF1 signalling.

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Autores principales:	Hiro Sato, Atsuko Niimi, Takaaki Yasuhara, Tiara Bunga Mayang Permata, Yoshihiko Hagiwara, Mayu Isono, Endang Nuryadi, Ryota Sekine, Takahiro Oike, Sangeeta Kakoti, Yuya Yoshimoto, Kathryn D. Held, Yoshiyuki Suzuki, Koji Kono, Kiyoshi Miyagawa, Takashi Nakano, Atsushi Shibata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3aa563dc071243218d3b85fb984faf73
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spelling	oai:doaj.org-article:3aa563dc071243218d3b85fb984faf732021-12-02T17:06:00ZDNA double-strand break repair pathway regulates PD-L1 expression in cancer cells10.1038/s41467-017-01883-92041-1723https://doaj.org/article/3aa563dc071243218d3b85fb984faf732017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01883-9https://doaj.org/toc/2041-1723PD-L1 is upregulated in many cancers due to exogenous cellular stress. Here the authors show that PD-L1 is upregulated in response to DNA double strand breaks via STAT and IRF1 signalling.Hiro SatoAtsuko NiimiTakaaki YasuharaTiara Bunga Mayang PermataYoshihiko HagiwaraMayu IsonoEndang NuryadiRyota SekineTakahiro OikeSangeeta KakotiYuya YoshimotoKathryn D. HeldYoshiyuki SuzukiKoji KonoKiyoshi MiyagawaTakashi NakanoAtsushi ShibataNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiro Sato Atsuko Niimi Takaaki Yasuhara Tiara Bunga Mayang Permata Yoshihiko Hagiwara Mayu Isono Endang Nuryadi Ryota Sekine Takahiro Oike Sangeeta Kakoti Yuya Yoshimoto Kathryn D. Held Yoshiyuki Suzuki Koji Kono Kiyoshi Miyagawa Takashi Nakano Atsushi Shibata DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
description	PD-L1 is upregulated in many cancers due to exogenous cellular stress. Here the authors show that PD-L1 is upregulated in response to DNA double strand breaks via STAT and IRF1 signalling.
format	article
author	Hiro Sato Atsuko Niimi Takaaki Yasuhara Tiara Bunga Mayang Permata Yoshihiko Hagiwara Mayu Isono Endang Nuryadi Ryota Sekine Takahiro Oike Sangeeta Kakoti Yuya Yoshimoto Kathryn D. Held Yoshiyuki Suzuki Koji Kono Kiyoshi Miyagawa Takashi Nakano Atsushi Shibata
author_facet	Hiro Sato Atsuko Niimi Takaaki Yasuhara Tiara Bunga Mayang Permata Yoshihiko Hagiwara Mayu Isono Endang Nuryadi Ryota Sekine Takahiro Oike Sangeeta Kakoti Yuya Yoshimoto Kathryn D. Held Yoshiyuki Suzuki Koji Kono Kiyoshi Miyagawa Takashi Nakano Atsushi Shibata
author_sort	Hiro Sato
title	DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
title_short	DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
title_full	DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
title_fullStr	DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
title_full_unstemmed	DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
title_sort	dna double-strand break repair pathway regulates pd-l1 expression in cancer cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3aa563dc071243218d3b85fb984faf73
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DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells

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