Severe COVID-19 and long COVID in a 31-year-old woman with incontinentia pigmenti: A case report

Incontinentia pigmenti is a rare genetic disease affecting the skin, microvasculature, and central nervous system, in which a hyperactive inflammatory response is observed. Due to the inflammatory phase of COVID-19 and associated cytokine storm, infection with SARS-CoV-2 in individuals with incontin...

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Autor principal:	Sylvie Rheault
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3aa63ab36dbd40c09a7b618433979c5c
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spelling	oai:doaj.org-article:3aa63ab36dbd40c09a7b618433979c5c2021-11-18T23:03:38ZSevere COVID-19 and long COVID in a 31-year-old woman with incontinentia pigmenti: A case report2050-313X10.1177/2050313X211059295https://doaj.org/article/3aa63ab36dbd40c09a7b618433979c5c2021-11-01T00:00:00Zhttps://doi.org/10.1177/2050313X211059295https://doaj.org/toc/2050-313XIncontinentia pigmenti is a rare genetic disease affecting the skin, microvasculature, and central nervous system, in which a hyperactive inflammatory response is observed. Due to the inflammatory phase of COVID-19 and associated cytokine storm, infection with SARS-CoV-2 in individuals with incontinentia pigmenti is a concern. Furthermore, type I interferon autoantibodies are found in life-threatening COVID-19 pneumonia and in 25% of individuals with incontinentia pigmenti. The present case report describes a 31-year-old Caucasian woman with incontinentia pigmenti and severe COVID-19. She was hospitalized for oxygen therapy, intravenous antibiotics, and corticosteroids. Eight months later, she is still symptomatic. To our knowledge, she is the first reported case of long COVID in incontinentia pigmenti. Increased autoimmunity may be implicated in both incontinentia pigmenti and long COVID. Pending evidence-based guidelines, COVID-protective measures including vaccination should be recommended to all patients with incontinentia pigmenti. Specific interferon therapy may be considered along with usual COVID treatment.Sylvie RheaultSAGE PublishingarticleMedicine (General)R5-920ENSAGE Open Medical Case Reports, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Sylvie Rheault Severe COVID-19 and long COVID in a 31-year-old woman with incontinentia pigmenti: A case report
description	Incontinentia pigmenti is a rare genetic disease affecting the skin, microvasculature, and central nervous system, in which a hyperactive inflammatory response is observed. Due to the inflammatory phase of COVID-19 and associated cytokine storm, infection with SARS-CoV-2 in individuals with incontinentia pigmenti is a concern. Furthermore, type I interferon autoantibodies are found in life-threatening COVID-19 pneumonia and in 25% of individuals with incontinentia pigmenti. The present case report describes a 31-year-old Caucasian woman with incontinentia pigmenti and severe COVID-19. She was hospitalized for oxygen therapy, intravenous antibiotics, and corticosteroids. Eight months later, she is still symptomatic. To our knowledge, she is the first reported case of long COVID in incontinentia pigmenti. Increased autoimmunity may be implicated in both incontinentia pigmenti and long COVID. Pending evidence-based guidelines, COVID-protective measures including vaccination should be recommended to all patients with incontinentia pigmenti. Specific interferon therapy may be considered along with usual COVID treatment.
format	article
author	Sylvie Rheault
author_facet	Sylvie Rheault
author_sort	Sylvie Rheault
title	Severe COVID-19 and long COVID in a 31-year-old woman with incontinentia pigmenti: A case report
title_short	Severe COVID-19 and long COVID in a 31-year-old woman with incontinentia pigmenti: A case report
title_full	Severe COVID-19 and long COVID in a 31-year-old woman with incontinentia pigmenti: A case report
title_fullStr	Severe COVID-19 and long COVID in a 31-year-old woman with incontinentia pigmenti: A case report
title_full_unstemmed	Severe COVID-19 and long COVID in a 31-year-old woman with incontinentia pigmenti: A case report
title_sort	severe covid-19 and long covid in a 31-year-old woman with incontinentia pigmenti: a case report
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/3aa63ab36dbd40c09a7b618433979c5c
work_keys_str_mv	AT sylvierheault severecovid19andlongcovidina31yearoldwomanwithincontinentiapigmentiacasereport
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Severe COVID-19 and long COVID in a 31-year-old woman with incontinentia pigmenti: A case report

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