Predicting Mortality in Patients with Atrial Fibrillation and Obstructive Chronic Coronary Syndrome: The Bialystok Coronary Project

Over the next decades, the prevalence of atrial fibrillation (AF) is estimated to double. Our aim was to investigate the causes of the long-term mortality in relation to the diagnosis of atrial fibrillation (AF) and chronic coronary syndrome (CCS). The analysed population consisted of 7367 consecuti...

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Autores principales:	Łukasz Kuźma, Anna Tomaszuk-Kazberuk, Anna Kurasz, Sławomir Dobrzycki, Marek Koziński, Bożena Sobkowicz, Gregory Y. H. Lip
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	atrial fibrillation chronic coronary syndrome coronary artery disease mortality AF-CAD study Medicine R
Acceso en línea:	https://doaj.org/article/3aa6fd65bc864e6baa0dab3d8d156a26
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spelling	oai:doaj.org-article:3aa6fd65bc864e6baa0dab3d8d156a262021-11-11T17:35:16ZPredicting Mortality in Patients with Atrial Fibrillation and Obstructive Chronic Coronary Syndrome: The Bialystok Coronary Project10.3390/jcm102149492077-0383https://doaj.org/article/3aa6fd65bc864e6baa0dab3d8d156a262021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4949https://doaj.org/toc/2077-0383Over the next decades, the prevalence of atrial fibrillation (AF) is estimated to double. Our aim was to investigate the causes of the long-term mortality in relation to the diagnosis of atrial fibrillation (AF) and chronic coronary syndrome (CCS). The analysed population consisted of 7367 consecutive patients referred for elective coronary angiography enrolled in a large single-centre retrospective registry, out of whom 1484 had AF and 2881 were diagnosed with obstructive CCS. During follow-up (median = 2029 days), 1201 patients died. The highest all-cause death was seen in AF(+)/CCS(+) [194/527; 36.8%], followed by AF(+)/CCS(−) [210/957; 21.9%], AF(−)/CCS(+) [(459/2354; 19.5%)] subgroups. AF ([HR]<sub>AC</sub> = 1.48, 95%CI, 1.09–2.01; HR<sub>CV</sub> = 1.34, 95%CI, 1.07–1.68) and obstructive CCS (HR<sub>AC</sub> = 1.90, 95%CI, 1.56–2.31; HR<sub>CV</sub> = 2.27, 95%CI, 1.94–2.65) together with age, male gender, heart failure, obstructive pulmonary disease, diabetes were predictors of both all-cause and CV mortality. The main findings are as follow among patients referred for elective coronary angiography, both AF and obstructive CCS are strong and independent predictors of the long-term mortality. Mortality of AF without CCS was at least as high as non-AF patients with CCS. CV deaths were more frequent than non-CV deaths in AF patients with CCS compared to those with either AF or CCS alone.Łukasz KuźmaAnna Tomaszuk-KazberukAnna KuraszSławomir DobrzyckiMarek KozińskiBożena SobkowiczGregory Y. H. LipMDPI AGarticleatrial fibrillationchronic coronary syndromecoronary artery diseasemortalityAF-CAD studyMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4949, p 4949 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atrial fibrillation chronic coronary syndrome coronary artery disease mortality AF-CAD study Medicine R
spellingShingle	atrial fibrillation chronic coronary syndrome coronary artery disease mortality AF-CAD study Medicine R Łukasz Kuźma Anna Tomaszuk-Kazberuk Anna Kurasz Sławomir Dobrzycki Marek Koziński Bożena Sobkowicz Gregory Y. H. Lip Predicting Mortality in Patients with Atrial Fibrillation and Obstructive Chronic Coronary Syndrome: The Bialystok Coronary Project
description	Over the next decades, the prevalence of atrial fibrillation (AF) is estimated to double. Our aim was to investigate the causes of the long-term mortality in relation to the diagnosis of atrial fibrillation (AF) and chronic coronary syndrome (CCS). The analysed population consisted of 7367 consecutive patients referred for elective coronary angiography enrolled in a large single-centre retrospective registry, out of whom 1484 had AF and 2881 were diagnosed with obstructive CCS. During follow-up (median = 2029 days), 1201 patients died. The highest all-cause death was seen in AF(+)/CCS(+) [194/527; 36.8%], followed by AF(+)/CCS(−) [210/957; 21.9%], AF(−)/CCS(+) [(459/2354; 19.5%)] subgroups. AF ([HR]<sub>AC</sub> = 1.48, 95%CI, 1.09–2.01; HR<sub>CV</sub> = 1.34, 95%CI, 1.07–1.68) and obstructive CCS (HR<sub>AC</sub> = 1.90, 95%CI, 1.56–2.31; HR<sub>CV</sub> = 2.27, 95%CI, 1.94–2.65) together with age, male gender, heart failure, obstructive pulmonary disease, diabetes were predictors of both all-cause and CV mortality. The main findings are as follow among patients referred for elective coronary angiography, both AF and obstructive CCS are strong and independent predictors of the long-term mortality. Mortality of AF without CCS was at least as high as non-AF patients with CCS. CV deaths were more frequent than non-CV deaths in AF patients with CCS compared to those with either AF or CCS alone.
format	article
author	Łukasz Kuźma Anna Tomaszuk-Kazberuk Anna Kurasz Sławomir Dobrzycki Marek Koziński Bożena Sobkowicz Gregory Y. H. Lip
author_facet	Łukasz Kuźma Anna Tomaszuk-Kazberuk Anna Kurasz Sławomir Dobrzycki Marek Koziński Bożena Sobkowicz Gregory Y. H. Lip
author_sort	Łukasz Kuźma
title	Predicting Mortality in Patients with Atrial Fibrillation and Obstructive Chronic Coronary Syndrome: The Bialystok Coronary Project
title_short	Predicting Mortality in Patients with Atrial Fibrillation and Obstructive Chronic Coronary Syndrome: The Bialystok Coronary Project
title_full	Predicting Mortality in Patients with Atrial Fibrillation and Obstructive Chronic Coronary Syndrome: The Bialystok Coronary Project
title_fullStr	Predicting Mortality in Patients with Atrial Fibrillation and Obstructive Chronic Coronary Syndrome: The Bialystok Coronary Project
title_full_unstemmed	Predicting Mortality in Patients with Atrial Fibrillation and Obstructive Chronic Coronary Syndrome: The Bialystok Coronary Project
title_sort	predicting mortality in patients with atrial fibrillation and obstructive chronic coronary syndrome: the bialystok coronary project
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3aa6fd65bc864e6baa0dab3d8d156a26
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Predicting Mortality in Patients with Atrial Fibrillation and Obstructive Chronic Coronary Syndrome: The Bialystok Coronary Project

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