Comparison between intravitreal bevacizumab and posterior sub-tenon injection of triamcinolone acetonide in macular edema secondary to retinal vein occlusion

Meng-Ju Tsai,1 Yi-Ting Hsieh,1,2 Yi-Jie Peng1 1Department of Ophthalmology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan; 2Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan Aim: To compare the efficacy and safety between posterior...

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Autores principales:	Tsai MJ, Hsieh YT, Peng YJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	sub-tenon injections macular edema retinal vein occlusion bevacizumab triamcinolone acetonide. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/3aa771c6ba1447c29bd2af9d60726136
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spelling	oai:doaj.org-article:3aa771c6ba1447c29bd2af9d607261362021-12-02T00:08:53ZComparison between intravitreal bevacizumab and posterior sub-tenon injection of triamcinolone acetonide in macular edema secondary to retinal vein occlusion1177-5483https://doaj.org/article/3aa771c6ba1447c29bd2af9d607261362018-07-01T00:00:00Zhttps://www.dovepress.com/comparison-between-intravitreal-bevacizumab-and-posterior-sub-tenon-in-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Meng-Ju Tsai,1 Yi-Ting Hsieh,1,2 Yi-Jie Peng1 1Department of Ophthalmology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan; 2Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan Aim: To compare the efficacy and safety between posterior sub-tenon injection of triamcinolone acetonide (PSTA) and intravitreal injection of bevacizumab (Avastin) (IVIA) in the treatment of macular edema secondary to retinal vein occlusion. Patients and methods: A total of 45 eyes were retrospectively enrolled (23 eyes with intravitreal bevacizumab and 22 eyes with posterior sub-tenon triamcinolone acetonide). Main endpoints included logMAR of best-corrected visual acuity (BCVA), central macular thickness (CMT), and intraocular pressure (IOP) before and after treatment at 6 months. Results: The mean logMAR improved from 0.78 to 0.56 at 6 months for intravitreal bevacizumab (p=0.001), and from 0.91 to 0.79 and 0.87 at 3 and 6 months (p=0.038 and 0.13), respectively, for sub-tenon triamcinolone acetonide. At 6 months, the BCVA was significantly better in the bevacizumab group (p=0.02). Both groups’ mean CMT significantly improved, from 478 µm at baseline to 295 µm at 6 months in IVIA group (p<0.001) and from 419 µm at baseline to 350 µm in PSTA group (p=0.012); however, this was not different between the groups at 6 months (p=0.065). Recurrence of macular edema was not different between the groups either (p=0.08). Poorer final vision was associated with poorer baseline BCVA and diagnosis of central retinal vein occlusion after adjustment for age and sex (p<0.001 and 0.012, respectively). Significant elevation of IOP was noted at 3 months in the PSTA group, but declined at 6 months compared with baseline (p=0.002 and 0.41, respectively). Conclusion: Intravitreal bevacizumab seemed to achieve better visual acuity compared with posterior sub-tenon injections of triamcinolone acetonide at 6 months, while CMT was comparable. PSTA still resulted in transient IOP elevation. Keywords: sub-tenon injections, macular edema, retinal vein occlusion, bevacizumab, triamcinolone acetonideTsai MJHsieh YTPeng YJDove Medical Pressarticlesub-tenon injectionsmacular edemaretinal vein occlusionbevacizumabtriamcinolone acetonide.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1229-1235 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	sub-tenon injections macular edema retinal vein occlusion bevacizumab triamcinolone acetonide. Ophthalmology RE1-994
spellingShingle	sub-tenon injections macular edema retinal vein occlusion bevacizumab triamcinolone acetonide. Ophthalmology RE1-994 Tsai MJ Hsieh YT Peng YJ Comparison between intravitreal bevacizumab and posterior sub-tenon injection of triamcinolone acetonide in macular edema secondary to retinal vein occlusion
description	Meng-Ju Tsai,1 Yi-Ting Hsieh,1,2 Yi-Jie Peng1 1Department of Ophthalmology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan; 2Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan Aim: To compare the efficacy and safety between posterior sub-tenon injection of triamcinolone acetonide (PSTA) and intravitreal injection of bevacizumab (Avastin) (IVIA) in the treatment of macular edema secondary to retinal vein occlusion. Patients and methods: A total of 45 eyes were retrospectively enrolled (23 eyes with intravitreal bevacizumab and 22 eyes with posterior sub-tenon triamcinolone acetonide). Main endpoints included logMAR of best-corrected visual acuity (BCVA), central macular thickness (CMT), and intraocular pressure (IOP) before and after treatment at 6 months. Results: The mean logMAR improved from 0.78 to 0.56 at 6 months for intravitreal bevacizumab (p=0.001), and from 0.91 to 0.79 and 0.87 at 3 and 6 months (p=0.038 and 0.13), respectively, for sub-tenon triamcinolone acetonide. At 6 months, the BCVA was significantly better in the bevacizumab group (p=0.02). Both groups’ mean CMT significantly improved, from 478 µm at baseline to 295 µm at 6 months in IVIA group (p<0.001) and from 419 µm at baseline to 350 µm in PSTA group (p=0.012); however, this was not different between the groups at 6 months (p=0.065). Recurrence of macular edema was not different between the groups either (p=0.08). Poorer final vision was associated with poorer baseline BCVA and diagnosis of central retinal vein occlusion after adjustment for age and sex (p<0.001 and 0.012, respectively). Significant elevation of IOP was noted at 3 months in the PSTA group, but declined at 6 months compared with baseline (p=0.002 and 0.41, respectively). Conclusion: Intravitreal bevacizumab seemed to achieve better visual acuity compared with posterior sub-tenon injections of triamcinolone acetonide at 6 months, while CMT was comparable. PSTA still resulted in transient IOP elevation. Keywords: sub-tenon injections, macular edema, retinal vein occlusion, bevacizumab, triamcinolone acetonide
format	article
author	Tsai MJ Hsieh YT Peng YJ
author_facet	Tsai MJ Hsieh YT Peng YJ
author_sort	Tsai MJ
title	Comparison between intravitreal bevacizumab and posterior sub-tenon injection of triamcinolone acetonide in macular edema secondary to retinal vein occlusion
title_short	Comparison between intravitreal bevacizumab and posterior sub-tenon injection of triamcinolone acetonide in macular edema secondary to retinal vein occlusion
title_full	Comparison between intravitreal bevacizumab and posterior sub-tenon injection of triamcinolone acetonide in macular edema secondary to retinal vein occlusion
title_fullStr	Comparison between intravitreal bevacizumab and posterior sub-tenon injection of triamcinolone acetonide in macular edema secondary to retinal vein occlusion
title_full_unstemmed	Comparison between intravitreal bevacizumab and posterior sub-tenon injection of triamcinolone acetonide in macular edema secondary to retinal vein occlusion
title_sort	comparison between intravitreal bevacizumab and posterior sub-tenon injection of triamcinolone acetonide in macular edema secondary to retinal vein occlusion
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/3aa771c6ba1447c29bd2af9d60726136
work_keys_str_mv	AT tsaimj comparisonbetweenintravitrealbevacizumabandposteriorsubtenoninjectionoftriamcinoloneacetonideinmacularedemasecondarytoretinalveinocclusion AT hsiehyt comparisonbetweenintravitrealbevacizumabandposteriorsubtenoninjectionoftriamcinoloneacetonideinmacularedemasecondarytoretinalveinocclusion AT pengyj comparisonbetweenintravitrealbevacizumabandposteriorsubtenoninjectionoftriamcinoloneacetonideinmacularedemasecondarytoretinalveinocclusion
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Comparison between intravitreal bevacizumab and posterior sub-tenon injection of triamcinolone acetonide in macular edema secondary to retinal vein occlusion

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