Management of chronic hepatitis C treatment failures: role of consensus interferon

Stevan A Gonzalez1, Emmet B Keeffe21Division of Hepatology, Baylor Regional Transplant Institute, Baylor All Saints Medical Center, Fort Worth and Baylor University Medical Center, Dallas, TX, USA; 2Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Cent...

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Autores principales:	Stevan A Gonzalez, Emmet B Keeffe
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3aac1b77d1aa4d11929e858c22b5ae77
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spelling	oai:doaj.org-article:3aac1b77d1aa4d11929e858c22b5ae772021-12-02T08:31:25ZManagement of chronic hepatitis C treatment failures: role of consensus interferon1177-54751177-5491https://doaj.org/article/3aac1b77d1aa4d11929e858c22b5ae772009-03-01T00:00:00Zhttp://www.dovepress.com/management-of-chronic-hepatitis-c-treatment-failures-role-of-consensus-a2965https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Stevan A Gonzalez1, Emmet B Keeffe21Division of Hepatology, Baylor Regional Transplant Institute, Baylor All Saints Medical Center, Fort Worth and Baylor University Medical Center, Dallas, TX, USA; 2Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Stanford, CA, USAAbstract: A significant proportion of patients with chronic hepatitis C virus (HCV) infection who undergo antiviral therapy have persistent or recurrent viremia and fail to achieve a sustained virologic response (SVR). Factors associated with treatment failure include HCV genotype 1 infection, high serum HCV RNA levels, and advanced fibrosis. Consensus interferon (CIFN) is a synthetic type I interferon derived from a consensus sequence of the most common amino acids found in naturally occurring alpha interferon subtypes. Several prospective clinical studies have demonstrated that CIFN may be a treatment option in patients who have failed prior interferonbased therapy, including those who have failed combination therapy with standard interferon or peginterferon plus ribavirin. Daily CIFN in combination with ribavirin may be an effective regimen in this setting; however, optimal dose and treatment duration of CIFN therapy have not been well established. Patients who achieve viral suppression during prior interferon-based therapy and those who do not have advanced fibrosis have a greater likelihood of achieving a SVR with CIFN retreatment. Individualized therapy targeting specific patient groups will be an important consideration in the successful management of prior treatment failures. Additional prospective studies are required in order to identify optimal treatment strategies for the use of CIFN in these patients.Keywords: consensus interferon, hepatitis C, interferon, nonresponder, relapser Stevan A GonzalezEmmet B KeeffeDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2009, Iss default, Pp 141-150 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Stevan A Gonzalez Emmet B Keeffe Management of chronic hepatitis C treatment failures: role of consensus interferon
description	Stevan A Gonzalez1, Emmet B Keeffe21Division of Hepatology, Baylor Regional Transplant Institute, Baylor All Saints Medical Center, Fort Worth and Baylor University Medical Center, Dallas, TX, USA; 2Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Stanford, CA, USAAbstract: A significant proportion of patients with chronic hepatitis C virus (HCV) infection who undergo antiviral therapy have persistent or recurrent viremia and fail to achieve a sustained virologic response (SVR). Factors associated with treatment failure include HCV genotype 1 infection, high serum HCV RNA levels, and advanced fibrosis. Consensus interferon (CIFN) is a synthetic type I interferon derived from a consensus sequence of the most common amino acids found in naturally occurring alpha interferon subtypes. Several prospective clinical studies have demonstrated that CIFN may be a treatment option in patients who have failed prior interferonbased therapy, including those who have failed combination therapy with standard interferon or peginterferon plus ribavirin. Daily CIFN in combination with ribavirin may be an effective regimen in this setting; however, optimal dose and treatment duration of CIFN therapy have not been well established. Patients who achieve viral suppression during prior interferon-based therapy and those who do not have advanced fibrosis have a greater likelihood of achieving a SVR with CIFN retreatment. Individualized therapy targeting specific patient groups will be an important consideration in the successful management of prior treatment failures. Additional prospective studies are required in order to identify optimal treatment strategies for the use of CIFN in these patients.Keywords: consensus interferon, hepatitis C, interferon, nonresponder, relapser
format	article
author	Stevan A Gonzalez Emmet B Keeffe
author_facet	Stevan A Gonzalez Emmet B Keeffe
author_sort	Stevan A Gonzalez
title	Management of chronic hepatitis C treatment failures: role of consensus interferon
title_short	Management of chronic hepatitis C treatment failures: role of consensus interferon
title_full	Management of chronic hepatitis C treatment failures: role of consensus interferon
title_fullStr	Management of chronic hepatitis C treatment failures: role of consensus interferon
title_full_unstemmed	Management of chronic hepatitis C treatment failures: role of consensus interferon
title_sort	management of chronic hepatitis c treatment failures: role of consensus interferon
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/3aac1b77d1aa4d11929e858c22b5ae77
work_keys_str_mv	AT stevanagonzalez managementofchronichepatitisctreatmentfailuresroleofconsensusinterferon AT emmetbkeeffe managementofchronichepatitisctreatmentfailuresroleofconsensusinterferon
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Management of chronic hepatitis C treatment failures: role of consensus interferon

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