IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis.

Idiopathic pulmonary fibrosis is a chronic, fibrosing interstitial pneumonia that presents with various clinical courses and progression ranging from rapid to slow. To identify novel biomarkers that can support the diagnosis and/or prognostic prediction of idiopathic pulmonary fibrosis, we performed...

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Autores principales:	Yu Nakanishi, Yasushi Horimasu, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Takeshi Masuda, Taku Nakashima, Shintaro Miyamoto, Hiroshi Iwamoto, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3aac23ddd55941028ca008fd20e9cf99
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spelling	oai:doaj.org-article:3aac23ddd55941028ca008fd20e9cf992021-12-02T20:11:04ZIL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis.1932-620310.1371/journal.pone.0252594https://doaj.org/article/3aac23ddd55941028ca008fd20e9cf992021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252594https://doaj.org/toc/1932-6203Idiopathic pulmonary fibrosis is a chronic, fibrosing interstitial pneumonia that presents with various clinical courses and progression ranging from rapid to slow. To identify novel biomarkers that can support the diagnosis and/or prognostic prediction of idiopathic pulmonary fibrosis, we performed gene expression analysis, and the mRNA of interleukin-18 binding protein was increasingly expressed in patients with idiopathic pulmonary fibrosis compared with healthy controls. Therefore, we hypothesized that the interleukin-18 binding protein can serve as a diagnostic and/or prognostic biomarker for idiopathic pulmonary fibrosis. We investigated the expression of interleukin-18 binding protein in lung tissue, bronchoalveolar lavage fluid, and serum. Additionally, the correlation between interleukin-18 binding protein expression levels and the extent of fibrosis was investigated using mouse models of lung fibrosis induced by subcutaneous bleomycin injections. Serum interleukin-18 binding protein levels were significantly higher in idiopathic pulmonary fibrosis patients (5.06 ng/mL, interquartile range [IQR]: 4.20-6.35) than in healthy volunteers (3.31 ng/mL, IQR: 2.84-3.99) (p < 0.001). Multivariate logistic regression models revealed that the correlation between serum interleukin-18 binding protein levels and idiopathic pulmonary fibrosis was statistically independent after adjustment for age, sex, and smoking status. Multivariate Cox proportional hazard models revealed that serum interleukin-18 binding protein levels were predictive of idiopathic pulmonary fibrosis disease prognosis independent of other covariate factors (hazard ratio: 1.655, 95% confidence interval: 1.224-2.237, p = 0.001). We also demonstrated a significant positive correlation between lung hydroxyproline expression levels and interleukin-18 binding protein levels in bronchoalveolar lavage fluid from bleomycin-treated mice (Spearman r = 0.509, p = 0.004). These results indicate the utility of interleukin-18 binding protein as a novel prognostic biomarker for idiopathic pulmonary fibrosis.Yu NakanishiYasushi HorimasuKakuhiro YamaguchiShinjiro SakamotoTakeshi MasudaTaku NakashimaShintaro MiyamotoHiroshi IwamotoShinichiro OhshimoKazunori FujitakaHironobu HamadaNoboru HattoriPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252594 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Nakanishi Yasushi Horimasu Kakuhiro Yamaguchi Shinjiro Sakamoto Takeshi Masuda Taku Nakashima Shintaro Miyamoto Hiroshi Iwamoto Shinichiro Ohshimo Kazunori Fujitaka Hironobu Hamada Noboru Hattori IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis.
description	Idiopathic pulmonary fibrosis is a chronic, fibrosing interstitial pneumonia that presents with various clinical courses and progression ranging from rapid to slow. To identify novel biomarkers that can support the diagnosis and/or prognostic prediction of idiopathic pulmonary fibrosis, we performed gene expression analysis, and the mRNA of interleukin-18 binding protein was increasingly expressed in patients with idiopathic pulmonary fibrosis compared with healthy controls. Therefore, we hypothesized that the interleukin-18 binding protein can serve as a diagnostic and/or prognostic biomarker for idiopathic pulmonary fibrosis. We investigated the expression of interleukin-18 binding protein in lung tissue, bronchoalveolar lavage fluid, and serum. Additionally, the correlation between interleukin-18 binding protein expression levels and the extent of fibrosis was investigated using mouse models of lung fibrosis induced by subcutaneous bleomycin injections. Serum interleukin-18 binding protein levels were significantly higher in idiopathic pulmonary fibrosis patients (5.06 ng/mL, interquartile range [IQR]: 4.20-6.35) than in healthy volunteers (3.31 ng/mL, IQR: 2.84-3.99) (p < 0.001). Multivariate logistic regression models revealed that the correlation between serum interleukin-18 binding protein levels and idiopathic pulmonary fibrosis was statistically independent after adjustment for age, sex, and smoking status. Multivariate Cox proportional hazard models revealed that serum interleukin-18 binding protein levels were predictive of idiopathic pulmonary fibrosis disease prognosis independent of other covariate factors (hazard ratio: 1.655, 95% confidence interval: 1.224-2.237, p = 0.001). We also demonstrated a significant positive correlation between lung hydroxyproline expression levels and interleukin-18 binding protein levels in bronchoalveolar lavage fluid from bleomycin-treated mice (Spearman r = 0.509, p = 0.004). These results indicate the utility of interleukin-18 binding protein as a novel prognostic biomarker for idiopathic pulmonary fibrosis.
format	article
author	Yu Nakanishi Yasushi Horimasu Kakuhiro Yamaguchi Shinjiro Sakamoto Takeshi Masuda Taku Nakashima Shintaro Miyamoto Hiroshi Iwamoto Shinichiro Ohshimo Kazunori Fujitaka Hironobu Hamada Noboru Hattori
author_facet	Yu Nakanishi Yasushi Horimasu Kakuhiro Yamaguchi Shinjiro Sakamoto Takeshi Masuda Taku Nakashima Shintaro Miyamoto Hiroshi Iwamoto Shinichiro Ohshimo Kazunori Fujitaka Hironobu Hamada Noboru Hattori
author_sort	Yu Nakanishi
title	IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis.
title_short	IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis.
title_full	IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis.
title_fullStr	IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis.
title_full_unstemmed	IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis.
title_sort	il-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3aac23ddd55941028ca008fd20e9cf99
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_version_	1718374938475233280

IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis.

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