Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? “The Pro Position”

Background: Crohn’s disease (CD) is a chronic inflammatory disorder affecting the gastrointestinal tract with disease behaviour based on the depth and severity of mucosal injury. Cumulative injury can result in complications including stricture formation and penetrating complications which often req...

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Autores principales:	Neil O’Moráin, Jayne Doherty, Roisin Stack, Glen A. Doherty
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	crohn’s disease disease assessment treatment targets clinical remission mucosal healing Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/3aad84e79955407fa3e45aba553780a9
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spelling	oai:doaj.org-article:3aad84e79955407fa3e45aba553780a92021-12-02T12:40:23ZMucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? “The Pro Position”2296-94032296-936510.1159/000519521https://doaj.org/article/3aad84e79955407fa3e45aba553780a92021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/519521https://doaj.org/toc/2296-9403https://doaj.org/toc/2296-9365Background: Crohn’s disease (CD) is a chronic inflammatory disorder affecting the gastrointestinal tract with disease behaviour based on the depth and severity of mucosal injury. Cumulative injury can result in complications including stricture formation and penetrating complications which often require surgical resection of diseased segments of the intestine resulting in significant morbidity. Accurate assessment of disease activity and appropriate treatment is essential in preventing complications. Summary: Treatment targets in the management of CD have evolved with the advent of more potent immunosuppressive therapy. Targeting the resolution of sub-clinical inflammation and achieving mucosal healing is associated with the prevention of stricturing and penetrating complications. Identifying non-invasive modalities to assess mucosal healing remains a challenge. Key Messages: Mucosal healing minimizes the risk of developing disease complications, prolongs steroid-free survival, and reduces hospitalization and the need for surgical intervention.Neil O’MoráinJayne DohertyRoisin StackGlen A. DohertyKarger Publishersarticlecrohn’s diseasedisease assessmenttreatment targetsclinical remissionmucosal healingDiseases of the digestive system. GastroenterologyRC799-869ENInflammatory Intestinal Diseases, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	crohn’s disease disease assessment treatment targets clinical remission mucosal healing Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	crohn’s disease disease assessment treatment targets clinical remission mucosal healing Diseases of the digestive system. Gastroenterology RC799-869 Neil O’Moráin Jayne Doherty Roisin Stack Glen A. Doherty Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? “The Pro Position”
description	Background: Crohn’s disease (CD) is a chronic inflammatory disorder affecting the gastrointestinal tract with disease behaviour based on the depth and severity of mucosal injury. Cumulative injury can result in complications including stricture formation and penetrating complications which often require surgical resection of diseased segments of the intestine resulting in significant morbidity. Accurate assessment of disease activity and appropriate treatment is essential in preventing complications. Summary: Treatment targets in the management of CD have evolved with the advent of more potent immunosuppressive therapy. Targeting the resolution of sub-clinical inflammation and achieving mucosal healing is associated with the prevention of stricturing and penetrating complications. Identifying non-invasive modalities to assess mucosal healing remains a challenge. Key Messages: Mucosal healing minimizes the risk of developing disease complications, prolongs steroid-free survival, and reduces hospitalization and the need for surgical intervention.
format	article
author	Neil O’Moráin Jayne Doherty Roisin Stack Glen A. Doherty
author_facet	Neil O’Moráin Jayne Doherty Roisin Stack Glen A. Doherty
author_sort	Neil O’Moráin
title	Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? “The Pro Position”
title_short	Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? “The Pro Position”
title_full	Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? “The Pro Position”
title_fullStr	Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? “The Pro Position”
title_full_unstemmed	Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? “The Pro Position”
title_sort	mucosal healing in crohn’s disease: bull’s eye or bust? “the pro position”
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/3aad84e79955407fa3e45aba553780a9
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Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? “The Pro Position”

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