Malaria Parasites Produce Volatile Mosquito Attractants

ABSTRACT The malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid organelle that possesses plant-like metabolic pathways. Plants use the plastidial isoprenoid biosynthesis pathway to produce volatile odorants, known as terpenes. In this work, we describe the volatile chemical...

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Autores principales:	Megan Kelly, Chih-Ying Su, Chad Schaber, Jan R. Crowley, Fong-Fu Hsu, John R. Carlson, Audrey R. Odom
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2015
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/3ab001dea6a64358a18135e500cd9175
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spelling	oai:doaj.org-article:3ab001dea6a64358a18135e500cd91752021-11-15T15:41:34ZMalaria Parasites Produce Volatile Mosquito Attractants10.1128/mBio.00235-152150-7511https://doaj.org/article/3ab001dea6a64358a18135e500cd91752015-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00235-15https://doaj.org/toc/2150-7511ABSTRACT The malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid organelle that possesses plant-like metabolic pathways. Plants use the plastidial isoprenoid biosynthesis pathway to produce volatile odorants, known as terpenes. In this work, we describe the volatile chemical profile of cultured malaria parasites. Among the identified compounds are several plant-like terpenes and terpene derivatives, including known mosquito attractants. We establish the molecular identity of the odorant receptors of the malaria mosquito vector Anopheles gambiae, which responds to these compounds. The malaria parasite produces volatile signals that are recognized by mosquitoes and may thereby mediate host attraction and facilitate transmission. IMPORTANCE Malaria is a key global health concern. Mosquitoes that transmit malaria are more attracted to malaria parasite-infected mammalian hosts. These studies aimed to understand the chemical signals produced by malaria parasites; such an understanding may lead to new transmission-blocking strategies or noninvasive malaria diagnostics.Megan KellyChih-Ying SuChad SchaberJan R. CrowleyFong-Fu HsuJohn R. CarlsonAudrey R. OdomAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 6, Iss 2 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Megan Kelly Chih-Ying Su Chad Schaber Jan R. Crowley Fong-Fu Hsu John R. Carlson Audrey R. Odom Malaria Parasites Produce Volatile Mosquito Attractants
description	ABSTRACT The malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid organelle that possesses plant-like metabolic pathways. Plants use the plastidial isoprenoid biosynthesis pathway to produce volatile odorants, known as terpenes. In this work, we describe the volatile chemical profile of cultured malaria parasites. Among the identified compounds are several plant-like terpenes and terpene derivatives, including known mosquito attractants. We establish the molecular identity of the odorant receptors of the malaria mosquito vector Anopheles gambiae, which responds to these compounds. The malaria parasite produces volatile signals that are recognized by mosquitoes and may thereby mediate host attraction and facilitate transmission. IMPORTANCE Malaria is a key global health concern. Mosquitoes that transmit malaria are more attracted to malaria parasite-infected mammalian hosts. These studies aimed to understand the chemical signals produced by malaria parasites; such an understanding may lead to new transmission-blocking strategies or noninvasive malaria diagnostics.
format	article
author	Megan Kelly Chih-Ying Su Chad Schaber Jan R. Crowley Fong-Fu Hsu John R. Carlson Audrey R. Odom
author_facet	Megan Kelly Chih-Ying Su Chad Schaber Jan R. Crowley Fong-Fu Hsu John R. Carlson Audrey R. Odom
author_sort	Megan Kelly
title	Malaria Parasites Produce Volatile Mosquito Attractants
title_short	Malaria Parasites Produce Volatile Mosquito Attractants
title_full	Malaria Parasites Produce Volatile Mosquito Attractants
title_fullStr	Malaria Parasites Produce Volatile Mosquito Attractants
title_full_unstemmed	Malaria Parasites Produce Volatile Mosquito Attractants
title_sort	malaria parasites produce volatile mosquito attractants
publisher	American Society for Microbiology
publishDate	2015
url	https://doaj.org/article/3ab001dea6a64358a18135e500cd9175
work_keys_str_mv	AT megankelly malariaparasitesproducevolatilemosquitoattractants AT chihyingsu malariaparasitesproducevolatilemosquitoattractants AT chadschaber malariaparasitesproducevolatilemosquitoattractants AT janrcrowley malariaparasitesproducevolatilemosquitoattractants AT fongfuhsu malariaparasitesproducevolatilemosquitoattractants AT johnrcarlson malariaparasitesproducevolatilemosquitoattractants AT audreyrodom malariaparasitesproducevolatilemosquitoattractants
_version_	1718427637580300288

Malaria Parasites Produce Volatile Mosquito Attractants

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