Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke

Abstract Acute ischemic stroke is associated with pulmonary complications, and often dexmedetomidine and propofol are used to decrease cerebral metabolic rate. However, it is unknown the immunomodulatory actions of dexmedetomidine and propofol on brain and lungs during acute ischemic stroke. The eff...

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Autores principales:	Giselle C. Sousa, Marcos Vinicius Fernandes, Fernanda F. Cruz, Mariana A. Antunes, Carla M. da Silva, Christina Takyia, Denise Battaglini, Cynthia S. Samary, Chiara Robba, Paolo Pelosi, Patricia R. M. Rocco, Pedro L. Silva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ab2bbadb21745a5b4c23dc621e4e38b
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spelling	oai:doaj.org-article:3ab2bbadb21745a5b4c23dc621e4e38b2021-12-05T12:14:51ZComparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke10.1038/s41598-021-02608-12045-2322https://doaj.org/article/3ab2bbadb21745a5b4c23dc621e4e38b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02608-1https://doaj.org/toc/2045-2322Abstract Acute ischemic stroke is associated with pulmonary complications, and often dexmedetomidine and propofol are used to decrease cerebral metabolic rate. However, it is unknown the immunomodulatory actions of dexmedetomidine and propofol on brain and lungs during acute ischemic stroke. The effects of dexmedetomidine and propofol were compared on perilesional brain tissue and lung damage after acute ischemic stroke in rats. Further, the mean amount of both sedatives was directly evaluated on alveolar macrophages and lung endothelial cells primarily extracted 24-h after acute ischemic stroke. In twenty-five Wistar rats, ischemic stroke was induced and after 24-h treated with sodium thiopental (STROKE), dexmedetomidine and propofol. Dexmedetomidine, compared to STROKE, reduced diffuse alveolar damage score [median(interquartile range); 12(7.8–15.3) vs. 19.5(18–24), p = 0.007)], bronchoconstriction index [2.28(2.08–2.36) vs. 2.64(2.53–2.77), p = 0.006], and TNF-α expression (p = 0.0003), while propofol increased VCAM-1 expression compared to STROKE (p = 0.0004). In perilesional brain tissue, dexmedetomidine, compared to STROKE, decreased TNF-α (p = 0.010), while propofol increased VCAM-1 compared to STROKE (p = 0.024). In alveolar macrophages and endothelial cells, dexmedetomidine decreased IL-6 and IL-1β compared to STROKE (p = 0.002, and p = 0.040, respectively), and reduced IL-1β compared to propofol (p = 0.014). Dexmedetomidine, but not propofol, induced brain and lung protection in experimental acute ischemic stroke.Giselle C. SousaMarcos Vinicius FernandesFernanda F. CruzMariana A. AntunesCarla M. da SilvaChristina TakyiaDenise BattagliniCynthia S. SamaryChiara RobbaPaolo PelosiPatricia R. M. RoccoPedro L. SilvaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giselle C. Sousa Marcos Vinicius Fernandes Fernanda F. Cruz Mariana A. Antunes Carla M. da Silva Christina Takyia Denise Battaglini Cynthia S. Samary Chiara Robba Paolo Pelosi Patricia R. M. Rocco Pedro L. Silva Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke
description	Abstract Acute ischemic stroke is associated with pulmonary complications, and often dexmedetomidine and propofol are used to decrease cerebral metabolic rate. However, it is unknown the immunomodulatory actions of dexmedetomidine and propofol on brain and lungs during acute ischemic stroke. The effects of dexmedetomidine and propofol were compared on perilesional brain tissue and lung damage after acute ischemic stroke in rats. Further, the mean amount of both sedatives was directly evaluated on alveolar macrophages and lung endothelial cells primarily extracted 24-h after acute ischemic stroke. In twenty-five Wistar rats, ischemic stroke was induced and after 24-h treated with sodium thiopental (STROKE), dexmedetomidine and propofol. Dexmedetomidine, compared to STROKE, reduced diffuse alveolar damage score [median(interquartile range); 12(7.8–15.3) vs. 19.5(18–24), p = 0.007)], bronchoconstriction index [2.28(2.08–2.36) vs. 2.64(2.53–2.77), p = 0.006], and TNF-α expression (p = 0.0003), while propofol increased VCAM-1 expression compared to STROKE (p = 0.0004). In perilesional brain tissue, dexmedetomidine, compared to STROKE, decreased TNF-α (p = 0.010), while propofol increased VCAM-1 compared to STROKE (p = 0.024). In alveolar macrophages and endothelial cells, dexmedetomidine decreased IL-6 and IL-1β compared to STROKE (p = 0.002, and p = 0.040, respectively), and reduced IL-1β compared to propofol (p = 0.014). Dexmedetomidine, but not propofol, induced brain and lung protection in experimental acute ischemic stroke.
format	article
author	Giselle C. Sousa Marcos Vinicius Fernandes Fernanda F. Cruz Mariana A. Antunes Carla M. da Silva Christina Takyia Denise Battaglini Cynthia S. Samary Chiara Robba Paolo Pelosi Patricia R. M. Rocco Pedro L. Silva
author_facet	Giselle C. Sousa Marcos Vinicius Fernandes Fernanda F. Cruz Mariana A. Antunes Carla M. da Silva Christina Takyia Denise Battaglini Cynthia S. Samary Chiara Robba Paolo Pelosi Patricia R. M. Rocco Pedro L. Silva
author_sort	Giselle C. Sousa
title	Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke
title_short	Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke
title_full	Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke
title_fullStr	Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke
title_full_unstemmed	Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke
title_sort	comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3ab2bbadb21745a5b4c23dc621e4e38b
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Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke

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