Irisin Is Correlated with Blood Pressure in Obstructive Sleep Apnea Patients

Background. Despite approximately 95% primary cases of hypertension, secondary hypertension seems to be common with resistant forms. Notably, obstructive sleep apnea (OSA) is known as a common cause of secondary hypertension and has a major characteristic of obesity. Irisin acts as a link between mu...

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Autores principales:	Xing Wang, Zhengjiao Zhang, Xiaoxin Lan, Keyou Fu, Guanhua Xu, Jingyi Zhao, Haibo Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/3ab510e7adc843bc86c2c9e23c2c9758
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spelling	oai:doaj.org-article:3ab510e7adc843bc86c2c9e23c2c97582021-11-22T01:09:49ZIrisin Is Correlated with Blood Pressure in Obstructive Sleep Apnea Patients2090-039210.1155/2021/4717349https://doaj.org/article/3ab510e7adc843bc86c2c9e23c2c97582021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4717349https://doaj.org/toc/2090-0392Background. Despite approximately 95% primary cases of hypertension, secondary hypertension seems to be common with resistant forms. Notably, obstructive sleep apnea (OSA) is known as a common cause of secondary hypertension and has a major characteristic of obesity. Irisin acts as a link between muscles and adipose tissues in obesity, playing an essential role in human blood pressure (BP) regulation. However, whether irisin is associated with secondary hypertension caused by OSA and how it takes effect essentially have not been elucidated. Purpose. To investigate the changes of irisin and its relationship with BP in OSA. Methods. 72 snoring patients finished Epworth Sleep Scale (ESS) evaluation before polysomnography (PSG). BP was the average of three brachial BP values by mercury sphygmomanometer. Serum irisin level was determined by enzyme-linked immunosorbent assay (ELISA). Results were analyzed by SPSS software. Results. Irisin was higher in the severe and quite severe group than that in control and nonsevere groups (p<0.05). For BP, significant differences were found between the control group and the other three groups (p<0.05) and between the quite severe and the other three groups (p≤0.001). Positive correlations were found between irisin and apnea-hypopnea index (AHI), AHI and BP, and irisin level and BP. Negative correlations were between irisin and SpO2 nadir and SpO2 nadir and BP. Positive correlation still existed between AHI and irisin even after adjusting for some obesity-related variables. Conclusions. Irisin may serve as a potential biomarker for severity of OSA independently of obesity and imply the development of hypertension.Xing WangZhengjiao ZhangXiaoxin LanKeyou FuGuanhua XuJingyi ZhaoHaibo YuanHindawi LimitedarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENInternational Journal of Hypertension, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Xing Wang Zhengjiao Zhang Xiaoxin Lan Keyou Fu Guanhua Xu Jingyi Zhao Haibo Yuan Irisin Is Correlated with Blood Pressure in Obstructive Sleep Apnea Patients
description	Background. Despite approximately 95% primary cases of hypertension, secondary hypertension seems to be common with resistant forms. Notably, obstructive sleep apnea (OSA) is known as a common cause of secondary hypertension and has a major characteristic of obesity. Irisin acts as a link between muscles and adipose tissues in obesity, playing an essential role in human blood pressure (BP) regulation. However, whether irisin is associated with secondary hypertension caused by OSA and how it takes effect essentially have not been elucidated. Purpose. To investigate the changes of irisin and its relationship with BP in OSA. Methods. 72 snoring patients finished Epworth Sleep Scale (ESS) evaluation before polysomnography (PSG). BP was the average of three brachial BP values by mercury sphygmomanometer. Serum irisin level was determined by enzyme-linked immunosorbent assay (ELISA). Results were analyzed by SPSS software. Results. Irisin was higher in the severe and quite severe group than that in control and nonsevere groups (p<0.05). For BP, significant differences were found between the control group and the other three groups (p<0.05) and between the quite severe and the other three groups (p≤0.001). Positive correlations were found between irisin and apnea-hypopnea index (AHI), AHI and BP, and irisin level and BP. Negative correlations were between irisin and SpO2 nadir and SpO2 nadir and BP. Positive correlation still existed between AHI and irisin even after adjusting for some obesity-related variables. Conclusions. Irisin may serve as a potential biomarker for severity of OSA independently of obesity and imply the development of hypertension.
format	article
author	Xing Wang Zhengjiao Zhang Xiaoxin Lan Keyou Fu Guanhua Xu Jingyi Zhao Haibo Yuan
author_facet	Xing Wang Zhengjiao Zhang Xiaoxin Lan Keyou Fu Guanhua Xu Jingyi Zhao Haibo Yuan
author_sort	Xing Wang
title	Irisin Is Correlated with Blood Pressure in Obstructive Sleep Apnea Patients
title_short	Irisin Is Correlated with Blood Pressure in Obstructive Sleep Apnea Patients
title_full	Irisin Is Correlated with Blood Pressure in Obstructive Sleep Apnea Patients
title_fullStr	Irisin Is Correlated with Blood Pressure in Obstructive Sleep Apnea Patients
title_full_unstemmed	Irisin Is Correlated with Blood Pressure in Obstructive Sleep Apnea Patients
title_sort	irisin is correlated with blood pressure in obstructive sleep apnea patients
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/3ab510e7adc843bc86c2c9e23c2c9758
work_keys_str_mv	AT xingwang irisiniscorrelatedwithbloodpressureinobstructivesleepapneapatients AT zhengjiaozhang irisiniscorrelatedwithbloodpressureinobstructivesleepapneapatients AT xiaoxinlan irisiniscorrelatedwithbloodpressureinobstructivesleepapneapatients AT keyoufu irisiniscorrelatedwithbloodpressureinobstructivesleepapneapatients AT guanhuaxu irisiniscorrelatedwithbloodpressureinobstructivesleepapneapatients AT jingyizhao irisiniscorrelatedwithbloodpressureinobstructivesleepapneapatients AT haiboyuan irisiniscorrelatedwithbloodpressureinobstructivesleepapneapatients
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Irisin Is Correlated with Blood Pressure in Obstructive Sleep Apnea Patients

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