Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women

The most representative indicator of vitamin D status in clinical practice is 25(OH)D<sub>3</sub>, but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin...

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Autores principales:	María José Toribio, Feliciano Priego-Capote, Beatriz Pérez-Gómez, Nerea Fernández de Larrea-Baz, Emma Ruiz-Moreno, Adela Castelló, Pilar Lucas, María Ángeles Sierra, Marina Nieves Pino, Mercedes Martínez-Cortés, María Dolores Luque de Castro, Virginia Lope, Marina Pollán
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Vit D<sub>3</sub> 25(OH)D<sub>3</sub> 1,25(OH)<sub>2</sub>D<sub>3</sub> 24,25(OH)<sub>2</sub>D<sub>3</sub> vitamin D metabolite ratios Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/3abb1c6e20044f21af4bb30d5f115864
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spelling	oai:doaj.org-article:3abb1c6e20044f21af4bb30d5f1158642021-11-25T18:33:43ZFactors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women10.3390/nu131137472072-6643https://doaj.org/article/3abb1c6e20044f21af4bb30d5f1158642021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3747https://doaj.org/toc/2072-6643The most representative indicator of vitamin D status in clinical practice is 25(OH)D<sub>3</sub>, but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VMRs) with potentially influential factors in premenopausal women. This is a cross-sectional study based on 1422 women, aged 39–50, recruited from a Madrid Medical Diagnostic Center. Participants answered an epidemiological and a food frequency questionnaire. Serum vitamin D metabolites were determined using an SPE–LC–MS/MS platform. The association between participant’s characteristics, vitamin D metabolites, and VMRs was quantified by multiple linear regression models. Mean 25(OH)D<sub>3</sub> concentration was 49.2 + 18.9 nmol/L, with greater deficits among obese, nulliparous, dark-skinned women, and with less sun exposure. A lower R2 ratio (1,25(OH)<sub>2</sub>D<sub>3</sub>/25(OH)D<sub>3</sub>) and a higher R4 (24,25(OH)<sub>2</sub>D<sub>3</sub>/1,25(OH)<sub>2</sub>D<sub>3</sub>) were observed in nulliparous women, with high sun exposure, and those with low caloric intake or high consumption of calcium, vitamin D supplements, or alcohol. Nulliparous women had lower R1 (25(OH)D<sub>3</sub>/Vit D<sub>3</sub>) and R3 (24,25(OH)<sub>2</sub>D<sub>3</sub>/25(OH)D<sub>3</sub>), and older women showed lower R3 and R4. Vitamin D status modified the association of the VMRs with seasons. VMRs can be complementary indicators of vitamin D status and its endogenous metabolism, and reveal the influence of certain individual characteristics on the expression of hydroxylase enzymes.María José ToribioFeliciano Priego-CapoteBeatriz Pérez-GómezNerea Fernández de Larrea-BazEmma Ruiz-MorenoAdela CastellóPilar LucasMaría Ángeles SierraMarina Nieves PinoMercedes Martínez-CortésMaría Dolores Luque de CastroVirginia LopeMarina PollánMDPI AGarticleVit D<sub>3</sub>25(OH)D<sub>3</sub>1,25(OH)<sub>2</sub>D<sub>3</sub>24,25(OH)<sub>2</sub>D<sub>3</sub>vitamin D metabolite ratiosNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3747, p 3747 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Vit D<sub>3</sub> 25(OH)D<sub>3</sub> 1,25(OH)<sub>2</sub>D<sub>3</sub> 24,25(OH)<sub>2</sub>D<sub>3</sub> vitamin D metabolite ratios Nutrition. Foods and food supply TX341-641
spellingShingle	Vit D<sub>3</sub> 25(OH)D<sub>3</sub> 1,25(OH)<sub>2</sub>D<sub>3</sub> 24,25(OH)<sub>2</sub>D<sub>3</sub> vitamin D metabolite ratios Nutrition. Foods and food supply TX341-641 María José Toribio Feliciano Priego-Capote Beatriz Pérez-Gómez Nerea Fernández de Larrea-Baz Emma Ruiz-Moreno Adela Castelló Pilar Lucas María Ángeles Sierra Marina Nieves Pino Mercedes Martínez-Cortés María Dolores Luque de Castro Virginia Lope Marina Pollán Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women
description	The most representative indicator of vitamin D status in clinical practice is 25(OH)D<sub>3</sub>, but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VMRs) with potentially influential factors in premenopausal women. This is a cross-sectional study based on 1422 women, aged 39–50, recruited from a Madrid Medical Diagnostic Center. Participants answered an epidemiological and a food frequency questionnaire. Serum vitamin D metabolites were determined using an SPE–LC–MS/MS platform. The association between participant’s characteristics, vitamin D metabolites, and VMRs was quantified by multiple linear regression models. Mean 25(OH)D<sub>3</sub> concentration was 49.2 + 18.9 nmol/L, with greater deficits among obese, nulliparous, dark-skinned women, and with less sun exposure. A lower R2 ratio (1,25(OH)<sub>2</sub>D<sub>3</sub>/25(OH)D<sub>3</sub>) and a higher R4 (24,25(OH)<sub>2</sub>D<sub>3</sub>/1,25(OH)<sub>2</sub>D<sub>3</sub>) were observed in nulliparous women, with high sun exposure, and those with low caloric intake or high consumption of calcium, vitamin D supplements, or alcohol. Nulliparous women had lower R1 (25(OH)D<sub>3</sub>/Vit D<sub>3</sub>) and R3 (24,25(OH)<sub>2</sub>D<sub>3</sub>/25(OH)D<sub>3</sub>), and older women showed lower R3 and R4. Vitamin D status modified the association of the VMRs with seasons. VMRs can be complementary indicators of vitamin D status and its endogenous metabolism, and reveal the influence of certain individual characteristics on the expression of hydroxylase enzymes.
format	article
author	María José Toribio Feliciano Priego-Capote Beatriz Pérez-Gómez Nerea Fernández de Larrea-Baz Emma Ruiz-Moreno Adela Castelló Pilar Lucas María Ángeles Sierra Marina Nieves Pino Mercedes Martínez-Cortés María Dolores Luque de Castro Virginia Lope Marina Pollán
author_facet	María José Toribio Feliciano Priego-Capote Beatriz Pérez-Gómez Nerea Fernández de Larrea-Baz Emma Ruiz-Moreno Adela Castelló Pilar Lucas María Ángeles Sierra Marina Nieves Pino Mercedes Martínez-Cortés María Dolores Luque de Castro Virginia Lope Marina Pollán
author_sort	María José Toribio
title	Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women
title_short	Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women
title_full	Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women
title_fullStr	Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women
title_full_unstemmed	Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women
title_sort	factors associated with serum vitamin d metabolites and vitamin d metabolite ratios in premenopausal women
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3abb1c6e20044f21af4bb30d5f115864
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Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women

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