The Effect of Dehydroepiandrosterone Treatment on Neurogenesis, Astrogliosis and Long-Term Cocaine-Seeking Behavior in a Cocaine Self-Administration Model in Rats

Cocaine addiction is an acquired behavioral state developed in vulnerable individuals after cocaine exposure. It is characterized by compulsive drug-seeking and high vulnerability to relapse even after prolonged abstinence, associated with decreased neurogenesis in the hippocampus. This addictive st...

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Autores principales:	Hadas Ahdoot-Levi, Ofri Croitoru, Tzofnat Bareli, Einav Sudai, Hilla Peér-Nissan, Avi Jacob, Iris Gispan, Rachel Maayan, Abraham Weizman, Gal Yadid
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	addiction neurogensis astrogliosis cocaine self-administration DHEA Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/3abd67f1f22141329c2802bae6bf2797
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spelling	oai:doaj.org-article:3abd67f1f22141329c2802bae6bf27972021-12-01T07:33:39ZThe Effect of Dehydroepiandrosterone Treatment on Neurogenesis, Astrogliosis and Long-Term Cocaine-Seeking Behavior in a Cocaine Self-Administration Model in Rats1662-453X10.3389/fnins.2021.773197https://doaj.org/article/3abd67f1f22141329c2802bae6bf27972021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.773197/fullhttps://doaj.org/toc/1662-453XCocaine addiction is an acquired behavioral state developed in vulnerable individuals after cocaine exposure. It is characterized by compulsive drug-seeking and high vulnerability to relapse even after prolonged abstinence, associated with decreased neurogenesis in the hippocampus. This addictive state is hypothesized to be a form of “memory disease” in which the drug exploits the physiological neuroplasticity mechanisms that mediate regular learning and memory processes. Therefore, a major focus of the field has been to identify the cocaine-induced neuroadaptations occurring in the usurped brain’s reward circuit. The neurosteroid dehydroepiandrosterone (DHEA) affects brain cell morphology, differentiation, neurotransmission, and memory. It also reduces drug-seeking behavior in an animal model of cocaine self-administration. Here, we examined the long-lasting effects of DHEA treatment on the attenuation of cocaine-seeking behavior. We also examined its short- and long-term influence on hippocampal cells architecture (neurons and astrocytes). Using a behavioral examination, immunohistochemical staining, and diffusion tensor imaging, we found an immediate effect on tissue density and activation of astrocytes, which has a continuous beneficial effect on neurogenesis and tissue organization. This research emphasizes the requites concert between astrocytes and neurons in the rehabilitation from addiction behavior. Thus, DHEA may serve as a treatment that corrects brain damage following exposure to and abstinence from cocaine.Hadas Ahdoot-LeviOfri CroitoruTzofnat BareliEinav SudaiEinav SudaiHilla Peér-NissanAvi JacobIris GispanRachel MaayanAbraham WeizmanAbraham WeizmanGal YadidGal YadidFrontiers Media S.A.articleaddictionneurogensisastrogliosiscocaineself-administrationDHEANeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	addiction neurogensis astrogliosis cocaine self-administration DHEA Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	addiction neurogensis astrogliosis cocaine self-administration DHEA Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Hadas Ahdoot-Levi Ofri Croitoru Tzofnat Bareli Einav Sudai Einav Sudai Hilla Peér-Nissan Avi Jacob Iris Gispan Rachel Maayan Abraham Weizman Abraham Weizman Gal Yadid Gal Yadid The Effect of Dehydroepiandrosterone Treatment on Neurogenesis, Astrogliosis and Long-Term Cocaine-Seeking Behavior in a Cocaine Self-Administration Model in Rats
description	Cocaine addiction is an acquired behavioral state developed in vulnerable individuals after cocaine exposure. It is characterized by compulsive drug-seeking and high vulnerability to relapse even after prolonged abstinence, associated with decreased neurogenesis in the hippocampus. This addictive state is hypothesized to be a form of “memory disease” in which the drug exploits the physiological neuroplasticity mechanisms that mediate regular learning and memory processes. Therefore, a major focus of the field has been to identify the cocaine-induced neuroadaptations occurring in the usurped brain’s reward circuit. The neurosteroid dehydroepiandrosterone (DHEA) affects brain cell morphology, differentiation, neurotransmission, and memory. It also reduces drug-seeking behavior in an animal model of cocaine self-administration. Here, we examined the long-lasting effects of DHEA treatment on the attenuation of cocaine-seeking behavior. We also examined its short- and long-term influence on hippocampal cells architecture (neurons and astrocytes). Using a behavioral examination, immunohistochemical staining, and diffusion tensor imaging, we found an immediate effect on tissue density and activation of astrocytes, which has a continuous beneficial effect on neurogenesis and tissue organization. This research emphasizes the requites concert between astrocytes and neurons in the rehabilitation from addiction behavior. Thus, DHEA may serve as a treatment that corrects brain damage following exposure to and abstinence from cocaine.
format	article
author	Hadas Ahdoot-Levi Ofri Croitoru Tzofnat Bareli Einav Sudai Einav Sudai Hilla Peér-Nissan Avi Jacob Iris Gispan Rachel Maayan Abraham Weizman Abraham Weizman Gal Yadid Gal Yadid
author_facet	Hadas Ahdoot-Levi Ofri Croitoru Tzofnat Bareli Einav Sudai Einav Sudai Hilla Peér-Nissan Avi Jacob Iris Gispan Rachel Maayan Abraham Weizman Abraham Weizman Gal Yadid Gal Yadid
author_sort	Hadas Ahdoot-Levi
title	The Effect of Dehydroepiandrosterone Treatment on Neurogenesis, Astrogliosis and Long-Term Cocaine-Seeking Behavior in a Cocaine Self-Administration Model in Rats
title_short	The Effect of Dehydroepiandrosterone Treatment on Neurogenesis, Astrogliosis and Long-Term Cocaine-Seeking Behavior in a Cocaine Self-Administration Model in Rats
title_full	The Effect of Dehydroepiandrosterone Treatment on Neurogenesis, Astrogliosis and Long-Term Cocaine-Seeking Behavior in a Cocaine Self-Administration Model in Rats
title_fullStr	The Effect of Dehydroepiandrosterone Treatment on Neurogenesis, Astrogliosis and Long-Term Cocaine-Seeking Behavior in a Cocaine Self-Administration Model in Rats
title_full_unstemmed	The Effect of Dehydroepiandrosterone Treatment on Neurogenesis, Astrogliosis and Long-Term Cocaine-Seeking Behavior in a Cocaine Self-Administration Model in Rats
title_sort	effect of dehydroepiandrosterone treatment on neurogenesis, astrogliosis and long-term cocaine-seeking behavior in a cocaine self-administration model in rats
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3abd67f1f22141329c2802bae6bf2797
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The Effect of Dehydroepiandrosterone Treatment on Neurogenesis, Astrogliosis and Long-Term Cocaine-Seeking Behavior in a Cocaine Self-Administration Model in Rats

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