Nanostructured magnesium has fewer detrimental effects on osteoblast function

Lucy Weng, Thomas J Webster School of Engineering and Department of Orthopedics, Brown University, Providence, RI, USA Abstract: Efforts have been made recently to implement nanoscale surface features on magnesium, a biodegradable metal, to increase bone formation. Compared with normal magnesium, na...

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Autores principales:	Weng L, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3abda2e2781f425cadc8505aeb2d1dd3
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spelling	oai:doaj.org-article:3abda2e2781f425cadc8505aeb2d1dd32021-12-02T06:04:01ZNanostructured magnesium has fewer detrimental effects on osteoblast function1176-91141178-2013https://doaj.org/article/3abda2e2781f425cadc8505aeb2d1dd32013-05-01T00:00:00Zhttp://www.dovepress.com/nanostructured-magnesium-has-fewer-detrimental-effects-on-osteoblast-f-a12973https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Lucy Weng, Thomas J Webster School of Engineering and Department of Orthopedics, Brown University, Providence, RI, USA Abstract: Efforts have been made recently to implement nanoscale surface features on magnesium, a biodegradable metal, to increase bone formation. Compared with normal magnesium, nanostructured magnesium has unique characteristics, including increased grain boundary properties, surface to volume ratio, surface roughness, and surface energy, which may influence the initial adsorption of proteins known to promote the function of osteoblasts (bone-forming cells). Previous studies have shown that one way to increase nanosurface roughness on magnesium is to soak the metal in NaOH. However, it has not been determined if degradation of magnesium is altered by creating nanoscale features on its surface to influence osteoblast density. The aim of the present in vitro study was to determine the influence of degradation of nanostructured magnesium, created by soaking in NaOH, on osteoblast density. Our results showed a less detrimental effect of magnesium degradation on osteoblast density when magnesium was treated with NaOH to create nanoscale surface features. The detrimental degradation products of magnesium are of significant concern when considering use of magnesium as an orthopedic implant material, and this study identified a surface treatment, ie, soaking in NaOH to create nanoscale features for magnesium that can improve its use in numerous orthopedic applications. Keywords: nanostructured magnesium, degradation, detrimental effects, osteoblastsWeng LWebster TJDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 1773-1781 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Weng L Webster TJ Nanostructured magnesium has fewer detrimental effects on osteoblast function
description	Lucy Weng, Thomas J Webster School of Engineering and Department of Orthopedics, Brown University, Providence, RI, USA Abstract: Efforts have been made recently to implement nanoscale surface features on magnesium, a biodegradable metal, to increase bone formation. Compared with normal magnesium, nanostructured magnesium has unique characteristics, including increased grain boundary properties, surface to volume ratio, surface roughness, and surface energy, which may influence the initial adsorption of proteins known to promote the function of osteoblasts (bone-forming cells). Previous studies have shown that one way to increase nanosurface roughness on magnesium is to soak the metal in NaOH. However, it has not been determined if degradation of magnesium is altered by creating nanoscale features on its surface to influence osteoblast density. The aim of the present in vitro study was to determine the influence of degradation of nanostructured magnesium, created by soaking in NaOH, on osteoblast density. Our results showed a less detrimental effect of magnesium degradation on osteoblast density when magnesium was treated with NaOH to create nanoscale surface features. The detrimental degradation products of magnesium are of significant concern when considering use of magnesium as an orthopedic implant material, and this study identified a surface treatment, ie, soaking in NaOH to create nanoscale features for magnesium that can improve its use in numerous orthopedic applications. Keywords: nanostructured magnesium, degradation, detrimental effects, osteoblasts
format	article
author	Weng L Webster TJ
author_facet	Weng L Webster TJ
author_sort	Weng L
title	Nanostructured magnesium has fewer detrimental effects on osteoblast function
title_short	Nanostructured magnesium has fewer detrimental effects on osteoblast function
title_full	Nanostructured magnesium has fewer detrimental effects on osteoblast function
title_fullStr	Nanostructured magnesium has fewer detrimental effects on osteoblast function
title_full_unstemmed	Nanostructured magnesium has fewer detrimental effects on osteoblast function
title_sort	nanostructured magnesium has fewer detrimental effects on osteoblast function
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/3abda2e2781f425cadc8505aeb2d1dd3
work_keys_str_mv	AT wengl nanostructuredmagnesiumhasfewerdetrimentaleffectsonosteoblastfunction AT webstertj nanostructuredmagnesiumhasfewerdetrimentaleffectsonosteoblastfunction
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Nanostructured magnesium has fewer detrimental effects on osteoblast function

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