Decreased heritability and emergence of novel genetic effects on pulse wave velocity from youth to young adulthood

Abstract Increased arterial stiffness measured by pulse wave velocity (PWV) is an important parameter in the assessment of cardiovascular risk. Our previous longitudinal study has demonstrated that carotid-distal PWV showed reasonable stability throughout youth and young adulthood. This stability mi...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Yisong Huang, Shaoyong Su, Harold Snieder, Frank Treiber, Gaston Kapuku, Xiaoling Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/3abf374d068543ff9a78e32266c2e979
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:3abf374d068543ff9a78e32266c2e979
record_format dspace
spelling oai:doaj.org-article:3abf374d068543ff9a78e32266c2e9792021-12-02T16:56:02ZDecreased heritability and emergence of novel genetic effects on pulse wave velocity from youth to young adulthood10.1038/s41598-021-88490-32045-2322https://doaj.org/article/3abf374d068543ff9a78e32266c2e9792021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88490-3https://doaj.org/toc/2045-2322Abstract Increased arterial stiffness measured by pulse wave velocity (PWV) is an important parameter in the assessment of cardiovascular risk. Our previous longitudinal study has demonstrated that carotid-distal PWV showed reasonable stability throughout youth and young adulthood. This stability might be driven by genetic factors that are expressed consistently over time. We aimed to illustrate the relative contributions of genetic and environmental factors to the stability of carotid-distal PWV from youth to young adulthood. We also examined potential ethnic differences. For this purpose, carotid-distal PWV was measured twice in 497 European American (EA) and African American (AA) twins, with an average interval time of 3 years. Twin modelling on PWV showed that heritability decreased over time (62–35%), with the nonshared environmental influences becoming larger. There was no correlation between the nonshared environmental factors on PWV measured at visit 1 and visit 2, with the phenotypic tracking correlation (r = 0.32) completely explained by shared genetic factors over time. Novel genetic influences were identified accounting for a significant part of the variance (19%) at the second measurement occasion. There was no evidence for ethnic differences. In summary, novel genetic effects appear during development into young adulthood and account for a considerable part of the variation in PWV. Environmental influences become larger with age for PWV.Yisong HuangShaoyong SuHarold SniederFrank TreiberGaston KapukuXiaoling WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Yisong Huang
Shaoyong Su
Harold Snieder
Frank Treiber
Gaston Kapuku
Xiaoling Wang
Decreased heritability and emergence of novel genetic effects on pulse wave velocity from youth to young adulthood
description Abstract Increased arterial stiffness measured by pulse wave velocity (PWV) is an important parameter in the assessment of cardiovascular risk. Our previous longitudinal study has demonstrated that carotid-distal PWV showed reasonable stability throughout youth and young adulthood. This stability might be driven by genetic factors that are expressed consistently over time. We aimed to illustrate the relative contributions of genetic and environmental factors to the stability of carotid-distal PWV from youth to young adulthood. We also examined potential ethnic differences. For this purpose, carotid-distal PWV was measured twice in 497 European American (EA) and African American (AA) twins, with an average interval time of 3 years. Twin modelling on PWV showed that heritability decreased over time (62–35%), with the nonshared environmental influences becoming larger. There was no correlation between the nonshared environmental factors on PWV measured at visit 1 and visit 2, with the phenotypic tracking correlation (r = 0.32) completely explained by shared genetic factors over time. Novel genetic influences were identified accounting for a significant part of the variance (19%) at the second measurement occasion. There was no evidence for ethnic differences. In summary, novel genetic effects appear during development into young adulthood and account for a considerable part of the variation in PWV. Environmental influences become larger with age for PWV.
format article
author Yisong Huang
Shaoyong Su
Harold Snieder
Frank Treiber
Gaston Kapuku
Xiaoling Wang
author_facet Yisong Huang
Shaoyong Su
Harold Snieder
Frank Treiber
Gaston Kapuku
Xiaoling Wang
author_sort Yisong Huang
title Decreased heritability and emergence of novel genetic effects on pulse wave velocity from youth to young adulthood
title_short Decreased heritability and emergence of novel genetic effects on pulse wave velocity from youth to young adulthood
title_full Decreased heritability and emergence of novel genetic effects on pulse wave velocity from youth to young adulthood
title_fullStr Decreased heritability and emergence of novel genetic effects on pulse wave velocity from youth to young adulthood
title_full_unstemmed Decreased heritability and emergence of novel genetic effects on pulse wave velocity from youth to young adulthood
title_sort decreased heritability and emergence of novel genetic effects on pulse wave velocity from youth to young adulthood
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/3abf374d068543ff9a78e32266c2e979
work_keys_str_mv AT yisonghuang decreasedheritabilityandemergenceofnovelgeneticeffectsonpulsewavevelocityfromyouthtoyoungadulthood
AT shaoyongsu decreasedheritabilityandemergenceofnovelgeneticeffectsonpulsewavevelocityfromyouthtoyoungadulthood
AT haroldsnieder decreasedheritabilityandemergenceofnovelgeneticeffectsonpulsewavevelocityfromyouthtoyoungadulthood
AT franktreiber decreasedheritabilityandemergenceofnovelgeneticeffectsonpulsewavevelocityfromyouthtoyoungadulthood
AT gastonkapuku decreasedheritabilityandemergenceofnovelgeneticeffectsonpulsewavevelocityfromyouthtoyoungadulthood
AT xiaolingwang decreasedheritabilityandemergenceofnovelgeneticeffectsonpulsewavevelocityfromyouthtoyoungadulthood
_version_ 1718382793791111168