Calcium functional imaging with high-resolution CT in the inner ear

Abstract Although the otolith and otolith organs correlate with vertigo and instability, there is no method to investigate them without harmful procedures. We will create the technique for 3D microanatomical images of them, and investigate the in vivo internal state and metabolisms. The otolith and...

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Autores principales:	Hisaya Tanioka, Sayaka Tanioka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ac2fb7a124e476cad89f877e077fa00
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spelling	oai:doaj.org-article:3ac2fb7a124e476cad89f877e077fa002021-12-02T16:30:10ZCalcium functional imaging with high-resolution CT in the inner ear10.1038/s41598-021-94857-32045-2322https://doaj.org/article/3ac2fb7a124e476cad89f877e077fa002021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94857-3https://doaj.org/toc/2045-2322Abstract Although the otolith and otolith organs correlate with vertigo and instability, there is no method to investigate them without harmful procedures. We will create the technique for 3D microanatomical images of them, and investigate the in vivo internal state and metabolisms. The otolith and otolith organs images were reconstructed from a texture synthesis algorithm under the skull volume rendering algorithm using a cutting-plane method. The utricular macula was elongated pea-shaped. The saccular macula was almost bud-shaped. The changes in the amount of CaCO3 in the maculae and the endolymphatic sac showed various morphologies, reflecting the balance status of each subject. Both shapes and volumes were not always constant depending on time. In Meniere’s disease (MD), the saccular macula was larger and the utricular macula was smaller. In benign paroxysmal positional vertigo (BPPV), the otolith increased in the utricular macula but did not change much in the saccular macula. The saccule, utricle, and endolymphatic sac were not constantly shaped according to their conditions. These created 3D microanatomical images can allow detailed observations of changes in physiological and biological information. This imaging technique will contribute to our understanding of pathology and calcium metabolism in the in vivo vestibulum.Hisaya TaniokaSayaka TaniokaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hisaya Tanioka Sayaka Tanioka Calcium functional imaging with high-resolution CT in the inner ear
description	Abstract Although the otolith and otolith organs correlate with vertigo and instability, there is no method to investigate them without harmful procedures. We will create the technique for 3D microanatomical images of them, and investigate the in vivo internal state and metabolisms. The otolith and otolith organs images were reconstructed from a texture synthesis algorithm under the skull volume rendering algorithm using a cutting-plane method. The utricular macula was elongated pea-shaped. The saccular macula was almost bud-shaped. The changes in the amount of CaCO3 in the maculae and the endolymphatic sac showed various morphologies, reflecting the balance status of each subject. Both shapes and volumes were not always constant depending on time. In Meniere’s disease (MD), the saccular macula was larger and the utricular macula was smaller. In benign paroxysmal positional vertigo (BPPV), the otolith increased in the utricular macula but did not change much in the saccular macula. The saccule, utricle, and endolymphatic sac were not constantly shaped according to their conditions. These created 3D microanatomical images can allow detailed observations of changes in physiological and biological information. This imaging technique will contribute to our understanding of pathology and calcium metabolism in the in vivo vestibulum.
format	article
author	Hisaya Tanioka Sayaka Tanioka
author_facet	Hisaya Tanioka Sayaka Tanioka
author_sort	Hisaya Tanioka
title	Calcium functional imaging with high-resolution CT in the inner ear
title_short	Calcium functional imaging with high-resolution CT in the inner ear
title_full	Calcium functional imaging with high-resolution CT in the inner ear
title_fullStr	Calcium functional imaging with high-resolution CT in the inner ear
title_full_unstemmed	Calcium functional imaging with high-resolution CT in the inner ear
title_sort	calcium functional imaging with high-resolution ct in the inner ear
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3ac2fb7a124e476cad89f877e077fa00
work_keys_str_mv	AT hisayatanioka calciumfunctionalimagingwithhighresolutionctintheinnerear AT sayakatanioka calciumfunctionalimagingwithhighresolutionctintheinnerear
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Calcium functional imaging with high-resolution CT in the inner ear

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