Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

Blocking immune checkpoints is a promising strategy to treat lung cancer, but patients often become resistant to the therapy. Here, the authors analyse resistance in mouse models of lung cancer and show in mice and two patients, an increase in the expression of TIM3, which is also involved in the im...

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Autores principales:	Shohei Koyama, Esra A. Akbay, Yvonne Y. Li, Grit S. Herter-Sprie, Kevin A. Buczkowski, William G. Richards, Leena Gandhi, Amanda J. Redig, Scott J. Rodig, Hajime Asahina, Robert E. Jones, Meghana M. Kulkarni, Mari Kuraguchi, Sangeetha Palakurthi, Peter E. Fecci, Bruce E. Johnson, Pasi A. Janne, Jeffrey A. Engelman, Sidharta P. Gangadharan, Daniel B. Costa, Gordon J. Freeman, Raphael Bueno, F. Stephen Hodi, Glenn Dranoff, Kwok-Kin Wong, Peter S. Hammerman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3ac32f342c6142d690ddf9986e6f2bee
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spelling	oai:doaj.org-article:3ac32f342c6142d690ddf9986e6f2bee2021-12-02T16:49:25ZAdaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints10.1038/ncomms105012041-1723https://doaj.org/article/3ac32f342c6142d690ddf9986e6f2bee2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10501https://doaj.org/toc/2041-1723Blocking immune checkpoints is a promising strategy to treat lung cancer, but patients often become resistant to the therapy. Here, the authors analyse resistance in mouse models of lung cancer and show in mice and two patients, an increase in the expression of TIM3, which is also involved in the immune response to cancer.Shohei KoyamaEsra A. AkbayYvonne Y. LiGrit S. Herter-SprieKevin A. BuczkowskiWilliam G. RichardsLeena GandhiAmanda J. RedigScott J. RodigHajime AsahinaRobert E. JonesMeghana M. KulkarniMari KuraguchiSangeetha PalakurthiPeter E. FecciBruce E. JohnsonPasi A. JanneJeffrey A. EngelmanSidharta P. GangadharanDaniel B. CostaGordon J. FreemanRaphael BuenoF. Stephen HodiGlenn DranoffKwok-Kin WongPeter S. HammermanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shohei Koyama Esra A. Akbay Yvonne Y. Li Grit S. Herter-Sprie Kevin A. Buczkowski William G. Richards Leena Gandhi Amanda J. Redig Scott J. Rodig Hajime Asahina Robert E. Jones Meghana M. Kulkarni Mari Kuraguchi Sangeetha Palakurthi Peter E. Fecci Bruce E. Johnson Pasi A. Janne Jeffrey A. Engelman Sidharta P. Gangadharan Daniel B. Costa Gordon J. Freeman Raphael Bueno F. Stephen Hodi Glenn Dranoff Kwok-Kin Wong Peter S. Hammerman Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
description	Blocking immune checkpoints is a promising strategy to treat lung cancer, but patients often become resistant to the therapy. Here, the authors analyse resistance in mouse models of lung cancer and show in mice and two patients, an increase in the expression of TIM3, which is also involved in the immune response to cancer.
format	article
author	Shohei Koyama Esra A. Akbay Yvonne Y. Li Grit S. Herter-Sprie Kevin A. Buczkowski William G. Richards Leena Gandhi Amanda J. Redig Scott J. Rodig Hajime Asahina Robert E. Jones Meghana M. Kulkarni Mari Kuraguchi Sangeetha Palakurthi Peter E. Fecci Bruce E. Johnson Pasi A. Janne Jeffrey A. Engelman Sidharta P. Gangadharan Daniel B. Costa Gordon J. Freeman Raphael Bueno F. Stephen Hodi Glenn Dranoff Kwok-Kin Wong Peter S. Hammerman
author_facet	Shohei Koyama Esra A. Akbay Yvonne Y. Li Grit S. Herter-Sprie Kevin A. Buczkowski William G. Richards Leena Gandhi Amanda J. Redig Scott J. Rodig Hajime Asahina Robert E. Jones Meghana M. Kulkarni Mari Kuraguchi Sangeetha Palakurthi Peter E. Fecci Bruce E. Johnson Pasi A. Janne Jeffrey A. Engelman Sidharta P. Gangadharan Daniel B. Costa Gordon J. Freeman Raphael Bueno F. Stephen Hodi Glenn Dranoff Kwok-Kin Wong Peter S. Hammerman
author_sort	Shohei Koyama
title	Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
title_short	Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
title_full	Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
title_fullStr	Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
title_full_unstemmed	Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
title_sort	adaptive resistance to therapeutic pd-1 blockade is associated with upregulation of alternative immune checkpoints
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3ac32f342c6142d690ddf9986e6f2bee
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Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

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