American Geriatrics Society-Beers Criteria and adverse drug reactions: a comparative cross-sectional study of Nigerian and South African older inpatients

Sule Ajibola Saka, Manimbulu Nlooto, Frasia Oosthuizen Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa Background: The Beers Criteria were developed with the aim of improving the safety of medicines among o...

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Autores principales:	Saka SA, Nlooto M, Oosthuizen F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	adverse reactions African older persons Beers criteria inappropriate medicine hospitalized Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/3acb41f060b643ff835d7be3203492c5
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spelling	oai:doaj.org-article:3acb41f060b643ff835d7be3203492c52021-12-02T07:12:43ZAmerican Geriatrics Society-Beers Criteria and adverse drug reactions: a comparative cross-sectional study of Nigerian and South African older inpatients1178-1998https://doaj.org/article/3acb41f060b643ff835d7be3203492c52018-11-01T00:00:00Zhttps://www.dovepress.com/american-geriatrics-society-beers-criteria-and-adverse-drug-reactions--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Sule Ajibola Saka, Manimbulu Nlooto, Frasia Oosthuizen Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa Background: The Beers Criteria were developed with the aim of improving the safety of medicines among older persons. While the association between the Beers’ list of potentially inappropriate medicines (PIMs) and adverse drug reactions (ADRs) among older Caucasians is contentious, the ability of the Criteria to predict ADRs among older persons in Africa remains unexplored.Objectives: This study aimed to compare the prevalence of PIMs and ADRs among hospitalized older persons in Nigeria and South Africa, and to determine the association between the 2015 American Geriatrics Society-Beers (AGS-Beers) PIMs and ADRs.Methods: The medical records of older persons aged ≥60 years who were hospitalized in teaching hospitals in Nigeria and South Africa were randomly selected, and retrospectively evaluated for ADRs by two clinical pharmacists using the Naranjo algorithm. The PIMs were assessed using the 2015 AGS-Beers Criteria. A multivariate logistic regression was used to determine the associated factors for ADRs among the hospitalized older persons, with P<0.05 being considered significant.Results: The samples which comprised 268 and 339 hospitalized older persons (mean age 70.53±8.22; 95% CI -0.21 to 2.32 vs mean age 69.49±7.64; 95% CI -0.25 to 2.34, P=0.11) were evaluated in Nigeria and South Africa, respectively. The PIMs among the older persons in Nigeria were 32.1% (86/268) and 30.1% (102/339, OR=0.91, 95% CI 0.64–1.29, P=0.6) for South Africa; 13.8% (37/268) of the hospitalized older persons in Nigeria experienced 43 cases of ADRs compared to 9.1% (31/339) in South Africa (95% CI 0.38–1.04, P=0.07). The multivariate analysis showed no association between PIMs and ADRs among the hospitalized older persons in Nigeria (OR=1.48 95% CI 0.70–3.17, P=0.31) and South Africa (OR=1.09, 95% CI 0.48–2.49, P=0.83).Conclusion: The 2015 AGS-Beers PIMs were not associated with ADRs among the hospitalized older persons in Nigeria and South Africa. However, physicians should be cautious when prescribing certain medications in the AGS-Beers list.Keywords: adverse drug reactions, African older persons, Beers Criteria, inappropriate medicine, hospitalized Saka SANlooto MOosthuizen FDove Medical Pressarticleadverse reactionsAfrican older personsBeers criteriainappropriate medicinehospitalizedGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 2375-2387 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	adverse reactions African older persons Beers criteria inappropriate medicine hospitalized Geriatrics RC952-954.6
spellingShingle	adverse reactions African older persons Beers criteria inappropriate medicine hospitalized Geriatrics RC952-954.6 Saka SA Nlooto M Oosthuizen F American Geriatrics Society-Beers Criteria and adverse drug reactions: a comparative cross-sectional study of Nigerian and South African older inpatients
description	Sule Ajibola Saka, Manimbulu Nlooto, Frasia Oosthuizen Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa Background: The Beers Criteria were developed with the aim of improving the safety of medicines among older persons. While the association between the Beers’ list of potentially inappropriate medicines (PIMs) and adverse drug reactions (ADRs) among older Caucasians is contentious, the ability of the Criteria to predict ADRs among older persons in Africa remains unexplored.Objectives: This study aimed to compare the prevalence of PIMs and ADRs among hospitalized older persons in Nigeria and South Africa, and to determine the association between the 2015 American Geriatrics Society-Beers (AGS-Beers) PIMs and ADRs.Methods: The medical records of older persons aged ≥60 years who were hospitalized in teaching hospitals in Nigeria and South Africa were randomly selected, and retrospectively evaluated for ADRs by two clinical pharmacists using the Naranjo algorithm. The PIMs were assessed using the 2015 AGS-Beers Criteria. A multivariate logistic regression was used to determine the associated factors for ADRs among the hospitalized older persons, with P<0.05 being considered significant.Results: The samples which comprised 268 and 339 hospitalized older persons (mean age 70.53±8.22; 95% CI -0.21 to 2.32 vs mean age 69.49±7.64; 95% CI -0.25 to 2.34, P=0.11) were evaluated in Nigeria and South Africa, respectively. The PIMs among the older persons in Nigeria were 32.1% (86/268) and 30.1% (102/339, OR=0.91, 95% CI 0.64–1.29, P=0.6) for South Africa; 13.8% (37/268) of the hospitalized older persons in Nigeria experienced 43 cases of ADRs compared to 9.1% (31/339) in South Africa (95% CI 0.38–1.04, P=0.07). The multivariate analysis showed no association between PIMs and ADRs among the hospitalized older persons in Nigeria (OR=1.48 95% CI 0.70–3.17, P=0.31) and South Africa (OR=1.09, 95% CI 0.48–2.49, P=0.83).Conclusion: The 2015 AGS-Beers PIMs were not associated with ADRs among the hospitalized older persons in Nigeria and South Africa. However, physicians should be cautious when prescribing certain medications in the AGS-Beers list.Keywords: adverse drug reactions, African older persons, Beers Criteria, inappropriate medicine, hospitalized
format	article
author	Saka SA Nlooto M Oosthuizen F
author_facet	Saka SA Nlooto M Oosthuizen F
author_sort	Saka SA
title	American Geriatrics Society-Beers Criteria and adverse drug reactions: a comparative cross-sectional study of Nigerian and South African older inpatients
title_short	American Geriatrics Society-Beers Criteria and adverse drug reactions: a comparative cross-sectional study of Nigerian and South African older inpatients
title_full	American Geriatrics Society-Beers Criteria and adverse drug reactions: a comparative cross-sectional study of Nigerian and South African older inpatients
title_fullStr	American Geriatrics Society-Beers Criteria and adverse drug reactions: a comparative cross-sectional study of Nigerian and South African older inpatients
title_full_unstemmed	American Geriatrics Society-Beers Criteria and adverse drug reactions: a comparative cross-sectional study of Nigerian and South African older inpatients
title_sort	american geriatrics society-beers criteria and adverse drug reactions: a comparative cross-sectional study of nigerian and south african older inpatients
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/3acb41f060b643ff835d7be3203492c5
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American Geriatrics Society-Beers Criteria and adverse drug reactions: a comparative cross-sectional study of Nigerian and South African older inpatients

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