An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A
Abstract Exposure to bisphenol A (BPA) in utero is associated with adverse health outcome of the offspring. Differential DNA methylation at specific CpG sites may link BPA exposure to health impacts. We examined the association of prenatal BPA exposure with genome-wide DNA methylation changes in cor...
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2019
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oai:doaj.org-article:3ad00696fdee40eaab97f5fac482ae172021-12-02T15:09:13ZAn epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A10.1038/s41598-019-48916-52045-2322https://doaj.org/article/3ad00696fdee40eaab97f5fac482ae172019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48916-5https://doaj.org/toc/2045-2322Abstract Exposure to bisphenol A (BPA) in utero is associated with adverse health outcome of the offspring. Differential DNA methylation at specific CpG sites may link BPA exposure to health impacts. We examined the association of prenatal BPA exposure with genome-wide DNA methylation changes in cord blood in 277 mother-child pairs in the Hokkaido Study on Environment and Children’s Health, using the Illumina HumanMethylation 450 BeadChip. We observed that a large portion of BPA-associated differentially methylated CpGs with p-value < 0.0001 was hypomethylated among all newborns (91%) and female infants (98%), as opposed to being hypermethylated (88%) among males. We found 27 and 16 CpGs with a false discovery rate (FDR) < 0.05 in the analyses for males and females, respectively. Genes annotated to FDR-corrected CpGs clustered into an interconnected genetic network among males, while they rarely exhibited any interactions in females. In contrast, none of the enrichment for gene ontology (GO) terms with FDR < 0.05 was observed for genes annotated to the male-specific CpGs with p < 0.0001, whereas the female-specific genes were significantly enriched for GO terms related to cell adhesion. Our epigenome-wide analysis of cord blood DNA methylation implies potential sex-specific epigenome responses to BPA exposure.Ryu MiuraAtsuko ArakiMachiko MinatoyaKunio MiyakeMei-Lien ChenSumitaka KobayashiChihiro MiyashitaJun YamamotoToru MatsumuraMayumi IshizukaTakeo KubotaReiko KishiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-13 (2019) |
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Medicine R Science Q Ryu Miura Atsuko Araki Machiko Minatoya Kunio Miyake Mei-Lien Chen Sumitaka Kobayashi Chihiro Miyashita Jun Yamamoto Toru Matsumura Mayumi Ishizuka Takeo Kubota Reiko Kishi An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A |
| description |
Abstract Exposure to bisphenol A (BPA) in utero is associated with adverse health outcome of the offspring. Differential DNA methylation at specific CpG sites may link BPA exposure to health impacts. We examined the association of prenatal BPA exposure with genome-wide DNA methylation changes in cord blood in 277 mother-child pairs in the Hokkaido Study on Environment and Children’s Health, using the Illumina HumanMethylation 450 BeadChip. We observed that a large portion of BPA-associated differentially methylated CpGs with p-value < 0.0001 was hypomethylated among all newborns (91%) and female infants (98%), as opposed to being hypermethylated (88%) among males. We found 27 and 16 CpGs with a false discovery rate (FDR) < 0.05 in the analyses for males and females, respectively. Genes annotated to FDR-corrected CpGs clustered into an interconnected genetic network among males, while they rarely exhibited any interactions in females. In contrast, none of the enrichment for gene ontology (GO) terms with FDR < 0.05 was observed for genes annotated to the male-specific CpGs with p < 0.0001, whereas the female-specific genes were significantly enriched for GO terms related to cell adhesion. Our epigenome-wide analysis of cord blood DNA methylation implies potential sex-specific epigenome responses to BPA exposure. |
| format |
article |
| author |
Ryu Miura Atsuko Araki Machiko Minatoya Kunio Miyake Mei-Lien Chen Sumitaka Kobayashi Chihiro Miyashita Jun Yamamoto Toru Matsumura Mayumi Ishizuka Takeo Kubota Reiko Kishi |
| author_facet |
Ryu Miura Atsuko Araki Machiko Minatoya Kunio Miyake Mei-Lien Chen Sumitaka Kobayashi Chihiro Miyashita Jun Yamamoto Toru Matsumura Mayumi Ishizuka Takeo Kubota Reiko Kishi |
| author_sort |
Ryu Miura |
| title |
An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A |
| title_short |
An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A |
| title_full |
An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A |
| title_fullStr |
An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A |
| title_full_unstemmed |
An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A |
| title_sort |
epigenome-wide analysis of cord blood dna methylation reveals sex-specific effect of exposure to bisphenol a |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/3ad00696fdee40eaab97f5fac482ae17 |
| work_keys_str_mv |
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