Blood bisphenol A concentration in patient with infertility affects in vitro fertilization outcomes

Aim. To analyze the relationship between bisphenol A levels in the blood of patients with infertility and in vitro fertilization (IVF) outcomes. Materials and methods. Infertility treatment of 301 married couples was performed using IVF. The level of bisphenol A in the blood of patients was deter...

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Autores principales:	Anastasia G. Syrkasheva, Svetlana V. Kindysheva, Nataliya L. Starodubtseva, Vladimir E. Frankevich, Nataliya V. Dolgushina
Formato:	article
Lenguaje:	RU
Publicado:	IP Berlin A.V. 2021
Materias:	in vitro fertilization pollutants pregnancy cytoplasmic dysmorphisms of oocytes mass-spectrometry bisphenol a miscarriage uterine myoma Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/3ad188b0a0f440639a9593952b34dbb0
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spelling	oai:doaj.org-article:3ad188b0a0f440639a9593952b34dbb02021-12-02T19:22:24ZBlood bisphenol A concentration in patient with infertility affects in vitro fertilization outcomes2079-56962079-583110.26442/20795696.2021.2.200706https://doaj.org/article/3ad188b0a0f440639a9593952b34dbb02021-05-01T00:00:00Zhttps://gynecology.orscience.ru/2079-5831/article/viewFile/71022/51877https://doaj.org/toc/2079-5696https://doaj.org/toc/2079-5831Aim. To analyze the relationship between bisphenol A levels in the blood of patients with infertility and in vitro fertilization (IVF) outcomes. Materials and methods. Infertility treatment of 301 married couples was performed using IVF. The level of bisphenol A in the blood of patients was determined by gas chromatography-mass spectrometry. The influence of bisphenol A levels on parameters of early embryogenesis and outcomes of IVF programs was assessed. Results. Bisphenol A was detected in 92.9% (277/298) blood samples of women and in 92.7% (141/154) blood samples of men. Bisphenol A levels in women had a statistically significant positive correlation with the level of bisphenol A in their spouses (r=0.533, p0.0001). No differences were found in the main parameters of early embryogenesis and pregnancy rates in quartile bisphenol A subgroups in women and men. There was a trend towards an increase in the miscarriage rate with an increase in the level of bisphenol A. The threshold level of bisphenol A that increased the miscarriage rate was 0.9 ng/ml for women and 0.4 ng/ml for men. With an increase in the threshold level of bisphenol A in both spouses (men 0.4 ng/ml and women 0.9 ng/ml), the odds ratio for miscarriage after IVF 8.8 (95% confidence interval 0.88113.08). Conclusions. Bisphenol A was found in the majority of infertile patients. A significant positive correlation was noted between the level of bisphenol A in patients and their spouses. An increase in the level of bisphenol A in the blood is associated with an increased risk of early reproductive losses after IVF, which requires further research.Anastasia G. SyrkashevaSvetlana V. KindyshevaNataliya L. StarodubtsevaVladimir E. FrankevichNataliya V. DolgushinaIP Berlin A.V. articlein vitro fertilizationpollutantspregnancycytoplasmic dysmorphisms of oocytesmass-spectrometrybisphenol amiscarriageuterine myomaGynecology and obstetricsRG1-991RUГинекология, Vol 23, Iss 2, Pp 161-166 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	in vitro fertilization pollutants pregnancy cytoplasmic dysmorphisms of oocytes mass-spectrometry bisphenol a miscarriage uterine myoma Gynecology and obstetrics RG1-991
spellingShingle	in vitro fertilization pollutants pregnancy cytoplasmic dysmorphisms of oocytes mass-spectrometry bisphenol a miscarriage uterine myoma Gynecology and obstetrics RG1-991 Anastasia G. Syrkasheva Svetlana V. Kindysheva Nataliya L. Starodubtseva Vladimir E. Frankevich Nataliya V. Dolgushina Blood bisphenol A concentration in patient with infertility affects in vitro fertilization outcomes
description	Aim. To analyze the relationship between bisphenol A levels in the blood of patients with infertility and in vitro fertilization (IVF) outcomes. Materials and methods. Infertility treatment of 301 married couples was performed using IVF. The level of bisphenol A in the blood of patients was determined by gas chromatography-mass spectrometry. The influence of bisphenol A levels on parameters of early embryogenesis and outcomes of IVF programs was assessed. Results. Bisphenol A was detected in 92.9% (277/298) blood samples of women and in 92.7% (141/154) blood samples of men. Bisphenol A levels in women had a statistically significant positive correlation with the level of bisphenol A in their spouses (r=0.533, p0.0001). No differences were found in the main parameters of early embryogenesis and pregnancy rates in quartile bisphenol A subgroups in women and men. There was a trend towards an increase in the miscarriage rate with an increase in the level of bisphenol A. The threshold level of bisphenol A that increased the miscarriage rate was 0.9 ng/ml for women and 0.4 ng/ml for men. With an increase in the threshold level of bisphenol A in both spouses (men 0.4 ng/ml and women 0.9 ng/ml), the odds ratio for miscarriage after IVF 8.8 (95% confidence interval 0.88113.08). Conclusions. Bisphenol A was found in the majority of infertile patients. A significant positive correlation was noted between the level of bisphenol A in patients and their spouses. An increase in the level of bisphenol A in the blood is associated with an increased risk of early reproductive losses after IVF, which requires further research.
format	article
author	Anastasia G. Syrkasheva Svetlana V. Kindysheva Nataliya L. Starodubtseva Vladimir E. Frankevich Nataliya V. Dolgushina
author_facet	Anastasia G. Syrkasheva Svetlana V. Kindysheva Nataliya L. Starodubtseva Vladimir E. Frankevich Nataliya V. Dolgushina
author_sort	Anastasia G. Syrkasheva
title	Blood bisphenol A concentration in patient with infertility affects in vitro fertilization outcomes
title_short	Blood bisphenol A concentration in patient with infertility affects in vitro fertilization outcomes
title_full	Blood bisphenol A concentration in patient with infertility affects in vitro fertilization outcomes
title_fullStr	Blood bisphenol A concentration in patient with infertility affects in vitro fertilization outcomes
title_full_unstemmed	Blood bisphenol A concentration in patient with infertility affects in vitro fertilization outcomes
title_sort	blood bisphenol a concentration in patient with infertility affects in vitro fertilization outcomes
publisher	IP Berlin A.V.
publishDate	2021
url	https://doaj.org/article/3ad188b0a0f440639a9593952b34dbb0
work_keys_str_mv	AT anastasiagsyrkasheva bloodbisphenolaconcentrationinpatientwithinfertilityaffectsinvitrofertilizationoutcomes AT svetlanavkindysheva bloodbisphenolaconcentrationinpatientwithinfertilityaffectsinvitrofertilizationoutcomes AT nataliyalstarodubtseva bloodbisphenolaconcentrationinpatientwithinfertilityaffectsinvitrofertilizationoutcomes AT vladimirefrankevich bloodbisphenolaconcentrationinpatientwithinfertilityaffectsinvitrofertilizationoutcomes AT nataliyavdolgushina bloodbisphenolaconcentrationinpatientwithinfertilityaffectsinvitrofertilizationoutcomes
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Blood bisphenol A concentration in patient with infertility affects in vitro fertilization outcomes

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