Development of nanoparticles derived from corn as mass producible bionanoparticles with anticancer activity

Abstract Recent studies showed that plant-derived nanoparticles (NPs) can be easily produced in high yields and have potential applications as therapeutic agents or delivery carriers for bioactive molecules. In this study, we selected corn as it is inexpensive to grow and mass-produced globally. Sup...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Daisuke Sasaki, Kosuke Kusamori, Yukiya Takayama, Shoko Itakura, Hiroaki Todo, Makiya Nishikawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ad506f4c34b4dada91c8ee949aefc8f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3ad506f4c34b4dada91c8ee949aefc8f
record_format	dspace
spelling	oai:doaj.org-article:3ad506f4c34b4dada91c8ee949aefc8f2021-11-28T12:21:26ZDevelopment of nanoparticles derived from corn as mass producible bionanoparticles with anticancer activity10.1038/s41598-021-02241-y2045-2322https://doaj.org/article/3ad506f4c34b4dada91c8ee949aefc8f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02241-yhttps://doaj.org/toc/2045-2322Abstract Recent studies showed that plant-derived nanoparticles (NPs) can be easily produced in high yields and have potential applications as therapeutic agents or delivery carriers for bioactive molecules. In this study, we selected corn as it is inexpensive to grow and mass-produced globally. Super sweet corn was homogenized in water to obtain corn juice, which was then centrifuged, filtered through a 0.45-μm-pore size syringe filter, and ultracentrifuged to obtain NPs derived from corn, or corn-derived NPs (cNPs). cNPs obtained were approximately 80 nm in diameter and negatively charged (− 17 mV). cNPs were taken up by various types of cells, including colon26 tumor cells and RAW264.7 macrophage-like cells, with selective reduction of the proliferation of colon26 cells. Moreover, cNPs induced tumor necrosis factor-α release from RAW264.7 cells. cNPs and RAW264.7 in combination significantly suppressed the proliferation of colon26/fluc cells. Daily intratumoral injections of cNPs significantly suppressed the growth of subcutaneous colon26 tumors in mice, with no significant body weight loss. These results indicate excellent anti-tumor activity of cNPs.Daisuke SasakiKosuke KusamoriYukiya TakayamaShoko ItakuraHiroaki TodoMakiya NishikawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daisuke Sasaki Kosuke Kusamori Yukiya Takayama Shoko Itakura Hiroaki Todo Makiya Nishikawa Development of nanoparticles derived from corn as mass producible bionanoparticles with anticancer activity
description	Abstract Recent studies showed that plant-derived nanoparticles (NPs) can be easily produced in high yields and have potential applications as therapeutic agents or delivery carriers for bioactive molecules. In this study, we selected corn as it is inexpensive to grow and mass-produced globally. Super sweet corn was homogenized in water to obtain corn juice, which was then centrifuged, filtered through a 0.45-μm-pore size syringe filter, and ultracentrifuged to obtain NPs derived from corn, or corn-derived NPs (cNPs). cNPs obtained were approximately 80 nm in diameter and negatively charged (− 17 mV). cNPs were taken up by various types of cells, including colon26 tumor cells and RAW264.7 macrophage-like cells, with selective reduction of the proliferation of colon26 cells. Moreover, cNPs induced tumor necrosis factor-α release from RAW264.7 cells. cNPs and RAW264.7 in combination significantly suppressed the proliferation of colon26/fluc cells. Daily intratumoral injections of cNPs significantly suppressed the growth of subcutaneous colon26 tumors in mice, with no significant body weight loss. These results indicate excellent anti-tumor activity of cNPs.
format	article
author	Daisuke Sasaki Kosuke Kusamori Yukiya Takayama Shoko Itakura Hiroaki Todo Makiya Nishikawa
author_facet	Daisuke Sasaki Kosuke Kusamori Yukiya Takayama Shoko Itakura Hiroaki Todo Makiya Nishikawa
author_sort	Daisuke Sasaki
title	Development of nanoparticles derived from corn as mass producible bionanoparticles with anticancer activity
title_short	Development of nanoparticles derived from corn as mass producible bionanoparticles with anticancer activity
title_full	Development of nanoparticles derived from corn as mass producible bionanoparticles with anticancer activity
title_fullStr	Development of nanoparticles derived from corn as mass producible bionanoparticles with anticancer activity
title_full_unstemmed	Development of nanoparticles derived from corn as mass producible bionanoparticles with anticancer activity
title_sort	development of nanoparticles derived from corn as mass producible bionanoparticles with anticancer activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3ad506f4c34b4dada91c8ee949aefc8f
work_keys_str_mv	AT daisukesasaki developmentofnanoparticlesderivedfromcornasmassproduciblebionanoparticleswithanticanceractivity AT kosukekusamori developmentofnanoparticlesderivedfromcornasmassproduciblebionanoparticleswithanticanceractivity AT yukiyatakayama developmentofnanoparticlesderivedfromcornasmassproduciblebionanoparticleswithanticanceractivity AT shokoitakura developmentofnanoparticlesderivedfromcornasmassproduciblebionanoparticleswithanticanceractivity AT hiroakitodo developmentofnanoparticlesderivedfromcornasmassproduciblebionanoparticleswithanticanceractivity AT makiyanishikawa developmentofnanoparticlesderivedfromcornasmassproduciblebionanoparticleswithanticanceractivity
_version_	1718408006466535424

Development of nanoparticles derived from corn as mass producible bionanoparticles with anticancer activity

Ejemplares similares