Detection of extensive cross-neutralization between pandemic and seasonal A/H1N1 Influenza Viruses using a pseudotype neutralization assay.

<h4>Background</h4>Cross-immunity between seasonal and pandemic A/H1N1 influenza viruses remains uncertain. In particular, the extent that previous infection or vaccination by seasonal A/H1N1 viruses can elicit protective immunity against pandemic A/H1N1 is unclear.<h4>Methodology/...

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Autores principales:	Béatrice Labrosse, Mathieu Tourdjman, Raphaël Porcher, Jérôme LeGoff, Xavier de Lamballerie, François Simon, Jean-Michel Molina, François Clavel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ad988adb05e4408b8d294822a5b6211
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spelling	oai:doaj.org-article:3ad988adb05e4408b8d294822a5b62112021-12-02T20:21:04ZDetection of extensive cross-neutralization between pandemic and seasonal A/H1N1 Influenza Viruses using a pseudotype neutralization assay.1932-620310.1371/journal.pone.0011036https://doaj.org/article/3ad988adb05e4408b8d294822a5b62112010-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20543954/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Cross-immunity between seasonal and pandemic A/H1N1 influenza viruses remains uncertain. In particular, the extent that previous infection or vaccination by seasonal A/H1N1 viruses can elicit protective immunity against pandemic A/H1N1 is unclear.<h4>Methodology/principal findings</h4>Neutralizing titers against seasonal A/H1N1 (A/Brisbane/59/2007) and against pandemic A/H1N1 (A/California/04/2009) were measured using an HIV-1-based pseudovirus neutralization assay. Using this highly sensitive assay, we found that a large fraction of subjects who had never been exposed to pandemic A/H1N1 express high levels of pandemic A/H1N1 neutralizing titers. A significant correlation was seen between neutralization of pandemic A/H1N1 and neutralization of a standard seasonal A/H1N1 strain. Significantly higher pandemic A/H1N1 neutralizing titers were measured in subjects who had received vaccination against seasonal influenza in 2008-2009. Higher pandemic neutralizing titers were also measured in subjects over 60 years of age.<h4>Conclusions/significance</h4>Our findings reveal that the extent of protective cross-immunity between seasonal and pandemic A/H1N1 influenza viruses may be more important than previously estimated. This cross-immunity could provide a possible explanation of the relatively mild profile of the recent influenza pandemic.Béatrice LabrosseMathieu TourdjmanRaphaël PorcherJérôme LeGoffXavier de LamballerieFrançois SimonJean-Michel MolinaFrançois ClavelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 6, p e11036 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Béatrice Labrosse Mathieu Tourdjman Raphaël Porcher Jérôme LeGoff Xavier de Lamballerie François Simon Jean-Michel Molina François Clavel Detection of extensive cross-neutralization between pandemic and seasonal A/H1N1 Influenza Viruses using a pseudotype neutralization assay.
description	<h4>Background</h4>Cross-immunity between seasonal and pandemic A/H1N1 influenza viruses remains uncertain. In particular, the extent that previous infection or vaccination by seasonal A/H1N1 viruses can elicit protective immunity against pandemic A/H1N1 is unclear.<h4>Methodology/principal findings</h4>Neutralizing titers against seasonal A/H1N1 (A/Brisbane/59/2007) and against pandemic A/H1N1 (A/California/04/2009) were measured using an HIV-1-based pseudovirus neutralization assay. Using this highly sensitive assay, we found that a large fraction of subjects who had never been exposed to pandemic A/H1N1 express high levels of pandemic A/H1N1 neutralizing titers. A significant correlation was seen between neutralization of pandemic A/H1N1 and neutralization of a standard seasonal A/H1N1 strain. Significantly higher pandemic A/H1N1 neutralizing titers were measured in subjects who had received vaccination against seasonal influenza in 2008-2009. Higher pandemic neutralizing titers were also measured in subjects over 60 years of age.<h4>Conclusions/significance</h4>Our findings reveal that the extent of protective cross-immunity between seasonal and pandemic A/H1N1 influenza viruses may be more important than previously estimated. This cross-immunity could provide a possible explanation of the relatively mild profile of the recent influenza pandemic.
format	article
author	Béatrice Labrosse Mathieu Tourdjman Raphaël Porcher Jérôme LeGoff Xavier de Lamballerie François Simon Jean-Michel Molina François Clavel
author_facet	Béatrice Labrosse Mathieu Tourdjman Raphaël Porcher Jérôme LeGoff Xavier de Lamballerie François Simon Jean-Michel Molina François Clavel
author_sort	Béatrice Labrosse
title	Detection of extensive cross-neutralization between pandemic and seasonal A/H1N1 Influenza Viruses using a pseudotype neutralization assay.
title_short	Detection of extensive cross-neutralization between pandemic and seasonal A/H1N1 Influenza Viruses using a pseudotype neutralization assay.
title_full	Detection of extensive cross-neutralization between pandemic and seasonal A/H1N1 Influenza Viruses using a pseudotype neutralization assay.
title_fullStr	Detection of extensive cross-neutralization between pandemic and seasonal A/H1N1 Influenza Viruses using a pseudotype neutralization assay.
title_full_unstemmed	Detection of extensive cross-neutralization between pandemic and seasonal A/H1N1 Influenza Viruses using a pseudotype neutralization assay.
title_sort	detection of extensive cross-neutralization between pandemic and seasonal a/h1n1 influenza viruses using a pseudotype neutralization assay.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/3ad988adb05e4408b8d294822a5b6211
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Detection of extensive cross-neutralization between pandemic and seasonal A/H1N1 Influenza Viruses using a pseudotype neutralization assay.

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