The association of Leptospermum honey with cytokine expression in the sinonasal epithelium of chronic rhinosinusitis patients

The association of Leptospermum honey with cytokine expression in the sinonasal epithelium of chronic rhinosinusitis patients

Objective: To identify the differences in cytokine expression between sinonasal tissue from patients treated with Leptospermum (Manuka) honey (LH) irrigation versus normal saline irrigation twice-daily for twelve weeks following sinus surgery (FESS). Methods: Forty-six CRS patients were recruited. S...

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Autores principales: Jamil Manji, Andrew Thamboo, Vishnu Sunkaraneni, Amrit Singh, Scott Tebbutt, Cathie Garnis, Amin Javer
Formato: article
Lenguaje:EN
Publicado: KeAi Communications Co., Ltd. 2019
Materias:
Otorhinolaryngology
RF1-547
Surgery
RD1-811
Acceso en línea:https://doaj.org/article/3adbe420f9b64de18e87d06835ae035a
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spelling oai:doaj.org-article:3adbe420f9b64de18e87d06835ae035a2021-12-02T14:11:32ZThe association of Leptospermum honey with cytokine expression in the sinonasal epithelium of chronic rhinosinusitis patients2095-881110.1016/j.wjorl.2018.07.004https://doaj.org/article/3adbe420f9b64de18e87d06835ae035a2019-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881118300295https://doaj.org/toc/2095-8811Objective: To identify the differences in cytokine expression between sinonasal tissue from patients treated with Leptospermum (Manuka) honey (LH) irrigation versus normal saline irrigation twice-daily for twelve weeks following sinus surgery (FESS). Methods: Forty-six CRS patients were recruited. Sinus tissue biopsies were collected during FESS and then at 5 and 12 weeks postoperatively during the course of treatment. A multi-plex cytokine assay quantified the abundance of 17 cytokines in biopsied tissue. Cytokine expression fold-change was analyzed between each time point using a robust linear regression model and compared between the two treatment groups. Results: Compared to the saline irrigation group, five cytokines were differently expressed (CI = 95%) in sinonasal tissue obtained from subjects in the LH irrigation group during the 12-week treatment period. Cytokines IL-6 (P = 0.0400), IL-8 (P = 0.0398), MCP-1 (P = 0.0284), and MIP-1β (P = 0.016) were significantly increased in the LH irrigation group compared to the saline irrigation group. IL-13 was significantly increased in the saline irrigation group compared to the LH group (P = 0.0086). Conclusion: LH may potentially act to modulate the expression of IL-6, IL-8, IL-13, MCP-1 and MIP-1β in sinonasal tissue. Keywords: Leptospermum honey, Sinusitis, Inflammation, Postoperative care, IrrigationJamil ManjiAndrew ThambooVishnu SunkaraneniAmrit SinghScott TebbuttCathie GarnisAmin JaverKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 5, Iss 1, Pp 19-25 (2019)
institution DOAJ
collection DOAJ
language EN
topic Otorhinolaryngology
RF1-547
Surgery
RD1-811
spellingShingle Otorhinolaryngology
RF1-547
Surgery
RD1-811
Jamil Manji
Andrew Thamboo
Vishnu Sunkaraneni
Amrit Singh
Scott Tebbutt
Cathie Garnis
Amin Javer
The association of Leptospermum honey with cytokine expression in the sinonasal epithelium of chronic rhinosinusitis patients
description Objective: To identify the differences in cytokine expression between sinonasal tissue from patients treated with Leptospermum (Manuka) honey (LH) irrigation versus normal saline irrigation twice-daily for twelve weeks following sinus surgery (FESS). Methods: Forty-six CRS patients were recruited. Sinus tissue biopsies were collected during FESS and then at 5 and 12 weeks postoperatively during the course of treatment. A multi-plex cytokine assay quantified the abundance of 17 cytokines in biopsied tissue. Cytokine expression fold-change was analyzed between each time point using a robust linear regression model and compared between the two treatment groups. Results: Compared to the saline irrigation group, five cytokines were differently expressed (CI = 95%) in sinonasal tissue obtained from subjects in the LH irrigation group during the 12-week treatment period. Cytokines IL-6 (P = 0.0400), IL-8 (P = 0.0398), MCP-1 (P = 0.0284), and MIP-1β (P = 0.016) were significantly increased in the LH irrigation group compared to the saline irrigation group. IL-13 was significantly increased in the saline irrigation group compared to the LH group (P = 0.0086). Conclusion: LH may potentially act to modulate the expression of IL-6, IL-8, IL-13, MCP-1 and MIP-1β in sinonasal tissue. Keywords: Leptospermum honey, Sinusitis, Inflammation, Postoperative care, Irrigation
format article
author Jamil Manji
Andrew Thamboo
Vishnu Sunkaraneni
Amrit Singh
Scott Tebbutt
Cathie Garnis
Amin Javer
author_facet Jamil Manji
Andrew Thamboo
Vishnu Sunkaraneni
Amrit Singh
Scott Tebbutt
Cathie Garnis
Amin Javer
author_sort Jamil Manji
title The association of Leptospermum honey with cytokine expression in the sinonasal epithelium of chronic rhinosinusitis patients
title_short The association of Leptospermum honey with cytokine expression in the sinonasal epithelium of chronic rhinosinusitis patients
title_full The association of Leptospermum honey with cytokine expression in the sinonasal epithelium of chronic rhinosinusitis patients
title_fullStr The association of Leptospermum honey with cytokine expression in the sinonasal epithelium of chronic rhinosinusitis patients
title_full_unstemmed The association of Leptospermum honey with cytokine expression in the sinonasal epithelium of chronic rhinosinusitis patients
title_sort association of leptospermum honey with cytokine expression in the sinonasal epithelium of chronic rhinosinusitis patients
publisher KeAi Communications Co., Ltd.
publishDate 2019
url https://doaj.org/article/3adbe420f9b64de18e87d06835ae035a
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