Total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females

Abstract The aim of this study was to examine the relationship between endogenous testosterone concentrations and lean mass and handgrip strength in healthy, pre-menopausal females. Testosterone has been positively associated with lean mass and strength in young and older males. Whether this relatio...

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Autores principales:	Sarah E. Alexander, Gavin Abbott, Brad Aisbett, Glenn D. Wadley, Jill A. Hnatiuk, Séverine Lamon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ae19a8768044041990651b580ebc901
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spelling	oai:doaj.org-article:3ae19a8768044041990651b580ebc9012021-12-02T16:50:31ZTotal testosterone is not associated with lean mass or handgrip strength in pre-menopausal females10.1038/s41598-021-89232-12045-2322https://doaj.org/article/3ae19a8768044041990651b580ebc9012021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89232-1https://doaj.org/toc/2045-2322Abstract The aim of this study was to examine the relationship between endogenous testosterone concentrations and lean mass and handgrip strength in healthy, pre-menopausal females. Testosterone has been positively associated with lean mass and strength in young and older males. Whether this relationship exists in pre-menopausal females is unknown. Secondary data from the 2013–2014 National Health and Nutrition Examination Survey were used to test this relationship. Females were aged 18–40 (n = 716, age 30 ± 6 years, mean ± SD) and pre-menopausal. Multivariate linear regression models were used to examine associations between total testosterone, lean mass index (LMI) and handgrip strength. Mean ± SD testosterone concentration was 1.0 ± 0.6 nmol L−1 and mean free androgen index (FAI) was 0.02 ± 0.02. In pre-menopausal females, testosterone was not associated with LMI (β = 0.05; 95%CI − 0.04, 0.15; p = 0.237) or handgrip strength (β = 0.01; 95%CI − 0.11, 0.12; p = 0.926) in a statistically significant manner. Conversely, FAI was associated with LMI (β = − 0.03; 95%CI − 0.05, − 0.02; p = 0.000) in a quadratic manner, meaning LMI increases with increasing FAI levels. Handgrip strength was not associated with FAI (β = 0.06; 95%CI − 0.02, 0.15; p = 0.137). These findings indicate that FAI, but not total testosterone, is associated with LMI in pre-menopausal females. Neither FAI nor total testosterone are associated with handgrip strength in pre-menopausal females when testosterone concentrations are not altered pharmacologically.Sarah E. AlexanderGavin AbbottBrad AisbettGlenn D. WadleyJill A. HnatiukSéverine LamonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sarah E. Alexander Gavin Abbott Brad Aisbett Glenn D. Wadley Jill A. Hnatiuk Séverine Lamon Total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females
description	Abstract The aim of this study was to examine the relationship between endogenous testosterone concentrations and lean mass and handgrip strength in healthy, pre-menopausal females. Testosterone has been positively associated with lean mass and strength in young and older males. Whether this relationship exists in pre-menopausal females is unknown. Secondary data from the 2013–2014 National Health and Nutrition Examination Survey were used to test this relationship. Females were aged 18–40 (n = 716, age 30 ± 6 years, mean ± SD) and pre-menopausal. Multivariate linear regression models were used to examine associations between total testosterone, lean mass index (LMI) and handgrip strength. Mean ± SD testosterone concentration was 1.0 ± 0.6 nmol L−1 and mean free androgen index (FAI) was 0.02 ± 0.02. In pre-menopausal females, testosterone was not associated with LMI (β = 0.05; 95%CI − 0.04, 0.15; p = 0.237) or handgrip strength (β = 0.01; 95%CI − 0.11, 0.12; p = 0.926) in a statistically significant manner. Conversely, FAI was associated with LMI (β = − 0.03; 95%CI − 0.05, − 0.02; p = 0.000) in a quadratic manner, meaning LMI increases with increasing FAI levels. Handgrip strength was not associated with FAI (β = 0.06; 95%CI − 0.02, 0.15; p = 0.137). These findings indicate that FAI, but not total testosterone, is associated with LMI in pre-menopausal females. Neither FAI nor total testosterone are associated with handgrip strength in pre-menopausal females when testosterone concentrations are not altered pharmacologically.
format	article
author	Sarah E. Alexander Gavin Abbott Brad Aisbett Glenn D. Wadley Jill A. Hnatiuk Séverine Lamon
author_facet	Sarah E. Alexander Gavin Abbott Brad Aisbett Glenn D. Wadley Jill A. Hnatiuk Séverine Lamon
author_sort	Sarah E. Alexander
title	Total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females
title_short	Total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females
title_full	Total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females
title_fullStr	Total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females
title_full_unstemmed	Total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females
title_sort	total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3ae19a8768044041990651b580ebc901
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Total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females

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