Disposal of iron by a mutant form of lipocalin 2

Iron overload can be either hereditary or acquired via transfusions, and current treatments include the use of iron chelators that have adverse effects in some patients. Here the authors modify siderocalin to enhance iron excretion in urine, and demonstrate therapeutic efficacy in iron overload mous...

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Autores principales:	Jonathan Barasch, Maria Hollmen, Rong Deng, Eldad A. Hod, Peter B. Rupert, Rebecca J. Abergel, Benjamin E. Allred, Katherine Xu, Shaun F. Darrah, Yared Tekabe, Alan Perlstein, Rebecca Wax, Efrat Bruck, Jacob Stauber, Kaitlyn A. Corbin, Charles Buchen, Vesna Slavkovich, Joseph Graziano, Steven L. Spitalnik, Guanhu Bao, Roland K. Strong, Andong Qiu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3ae332e27072492dad5e0ff733401a56
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spelling	oai:doaj.org-article:3ae332e27072492dad5e0ff733401a562021-12-02T17:32:36ZDisposal of iron by a mutant form of lipocalin 210.1038/ncomms129732041-1723https://doaj.org/article/3ae332e27072492dad5e0ff733401a562016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12973https://doaj.org/toc/2041-1723Iron overload can be either hereditary or acquired via transfusions, and current treatments include the use of iron chelators that have adverse effects in some patients. Here the authors modify siderocalin to enhance iron excretion in urine, and demonstrate therapeutic efficacy in iron overload mouse models.Jonathan BaraschMaria HollmenRong DengEldad A. HodPeter B. RupertRebecca J. AbergelBenjamin E. AllredKatherine XuShaun F. DarrahYared TekabeAlan PerlsteinRebecca WaxEfrat BruckJacob StauberKaitlyn A. CorbinCharles BuchenVesna SlavkovichJoseph GrazianoSteven L. SpitalnikGuanhu BaoRoland K. StrongAndong QiuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jonathan Barasch Maria Hollmen Rong Deng Eldad A. Hod Peter B. Rupert Rebecca J. Abergel Benjamin E. Allred Katherine Xu Shaun F. Darrah Yared Tekabe Alan Perlstein Rebecca Wax Efrat Bruck Jacob Stauber Kaitlyn A. Corbin Charles Buchen Vesna Slavkovich Joseph Graziano Steven L. Spitalnik Guanhu Bao Roland K. Strong Andong Qiu Disposal of iron by a mutant form of lipocalin 2
description	Iron overload can be either hereditary or acquired via transfusions, and current treatments include the use of iron chelators that have adverse effects in some patients. Here the authors modify siderocalin to enhance iron excretion in urine, and demonstrate therapeutic efficacy in iron overload mouse models.
format	article
author	Jonathan Barasch Maria Hollmen Rong Deng Eldad A. Hod Peter B. Rupert Rebecca J. Abergel Benjamin E. Allred Katherine Xu Shaun F. Darrah Yared Tekabe Alan Perlstein Rebecca Wax Efrat Bruck Jacob Stauber Kaitlyn A. Corbin Charles Buchen Vesna Slavkovich Joseph Graziano Steven L. Spitalnik Guanhu Bao Roland K. Strong Andong Qiu
author_facet	Jonathan Barasch Maria Hollmen Rong Deng Eldad A. Hod Peter B. Rupert Rebecca J. Abergel Benjamin E. Allred Katherine Xu Shaun F. Darrah Yared Tekabe Alan Perlstein Rebecca Wax Efrat Bruck Jacob Stauber Kaitlyn A. Corbin Charles Buchen Vesna Slavkovich Joseph Graziano Steven L. Spitalnik Guanhu Bao Roland K. Strong Andong Qiu
author_sort	Jonathan Barasch
title	Disposal of iron by a mutant form of lipocalin 2
title_short	Disposal of iron by a mutant form of lipocalin 2
title_full	Disposal of iron by a mutant form of lipocalin 2
title_fullStr	Disposal of iron by a mutant form of lipocalin 2
title_full_unstemmed	Disposal of iron by a mutant form of lipocalin 2
title_sort	disposal of iron by a mutant form of lipocalin 2
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3ae332e27072492dad5e0ff733401a56
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Disposal of iron by a mutant form of lipocalin 2

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