Impact of antibiotics on smell dysfunction

Objective: Viral or bacterial respiratory infections can cause long-lasting olfactory dysfunction. Antibiotic therapy is indicated in severe cases; however, it is unclear whether antibiotic use produces a positive, negative, or null effect on olfactory function. This retrospective study sought to de...

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Autores principales:	Jing-Jie Wang, Jonathan Chen, Richard L. Doty
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2018
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/3ae3967d38d64f6cad0546c8832dd50e
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spelling	oai:doaj.org-article:3ae3967d38d64f6cad0546c8832dd50e2021-12-02T13:39:14ZImpact of antibiotics on smell dysfunction2095-881110.1016/j.wjorl.2018.03.002https://doaj.org/article/3ae3967d38d64f6cad0546c8832dd50e2018-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881118300210https://doaj.org/toc/2095-8811Objective: Viral or bacterial respiratory infections can cause long-lasting olfactory dysfunction. Antibiotic therapy is indicated in severe cases; however, it is unclear whether antibiotic use produces a positive, negative, or null effect on olfactory function. This retrospective study sought to determine whether antibiotic use has an influence on odor identification and detection threshold test scores of patients with smell dysfunction secondary to upper respiratory infections (URIs), lower respiratory infections (LRIs), or rhinosinusitis. Methods: Data from a total of 288 patients presenting to the University of Pennsylvania Smell and Taste Center were evaluated. Results: Patients with a URI etiology who had taken bactericidal antibiotics had lower detection thresholds than did patients who had not taken antibiotics (P < 0.023; analysis of covariance with age and time since infection onset as covariates). Moreover, thresholds were lower for bactericidal antibiotic users than for bacteriostatic antibiotic users with either URI (P = 0.023) or rhinosinusitis (P = 0.028) etiologies. No meaningful influences of antibiotics on the odor identification test scores were evident. Conclusions: These findings, which need to be confirmed in prospective double-blind studies, suggest that bactericidal antibiotic therapy may be beneficial in mitigating, at least to some degree, chronic decrements in smell sensitivity due to URIs and rhinosinusitis. Keywords: Antibiotics, Rhinosinusitis, Viruses, Bacteria, OlfactionJing-Jie WangJonathan ChenRichard L. DotyKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 4, Iss 1, Pp 33-38 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 Jing-Jie Wang Jonathan Chen Richard L. Doty Impact of antibiotics on smell dysfunction
description	Objective: Viral or bacterial respiratory infections can cause long-lasting olfactory dysfunction. Antibiotic therapy is indicated in severe cases; however, it is unclear whether antibiotic use produces a positive, negative, or null effect on olfactory function. This retrospective study sought to determine whether antibiotic use has an influence on odor identification and detection threshold test scores of patients with smell dysfunction secondary to upper respiratory infections (URIs), lower respiratory infections (LRIs), or rhinosinusitis. Methods: Data from a total of 288 patients presenting to the University of Pennsylvania Smell and Taste Center were evaluated. Results: Patients with a URI etiology who had taken bactericidal antibiotics had lower detection thresholds than did patients who had not taken antibiotics (P < 0.023; analysis of covariance with age and time since infection onset as covariates). Moreover, thresholds were lower for bactericidal antibiotic users than for bacteriostatic antibiotic users with either URI (P = 0.023) or rhinosinusitis (P = 0.028) etiologies. No meaningful influences of antibiotics on the odor identification test scores were evident. Conclusions: These findings, which need to be confirmed in prospective double-blind studies, suggest that bactericidal antibiotic therapy may be beneficial in mitigating, at least to some degree, chronic decrements in smell sensitivity due to URIs and rhinosinusitis. Keywords: Antibiotics, Rhinosinusitis, Viruses, Bacteria, Olfaction
format	article
author	Jing-Jie Wang Jonathan Chen Richard L. Doty
author_facet	Jing-Jie Wang Jonathan Chen Richard L. Doty
author_sort	Jing-Jie Wang
title	Impact of antibiotics on smell dysfunction
title_short	Impact of antibiotics on smell dysfunction
title_full	Impact of antibiotics on smell dysfunction
title_fullStr	Impact of antibiotics on smell dysfunction
title_full_unstemmed	Impact of antibiotics on smell dysfunction
title_sort	impact of antibiotics on smell dysfunction
publisher	KeAi Communications Co., Ltd.
publishDate	2018
url	https://doaj.org/article/3ae3967d38d64f6cad0546c8832dd50e
work_keys_str_mv	AT jingjiewang impactofantibioticsonsmelldysfunction AT jonathanchen impactofantibioticsonsmelldysfunction AT richardldoty impactofantibioticsonsmelldysfunction
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Impact of antibiotics on smell dysfunction

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