Skeletal muscle mass to visceral fat area ratio is an important determinant associated with type 2 diabetes and metabolic syndrome

Qian Wang,1–4 Dongmei Zheng,1–3 Jia Liu,1–3 Li Fang,1–3 Qiu Li1–31Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People’s Republic of China; 2Shandong Clinical Medical Center of...

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Autores principales:	Wang Q, Zheng D, Liu J, Fang L, Li Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	metabolic syndrome diabetes mellitus skeletal muscle mass visceral fat area Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/3ae59334c8f04ab298151a511b7e7b31
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spelling	oai:doaj.org-article:3ae59334c8f04ab298151a511b7e7b312021-12-02T10:48:27ZSkeletal muscle mass to visceral fat area ratio is an important determinant associated with type 2 diabetes and metabolic syndrome1178-7007https://doaj.org/article/3ae59334c8f04ab298151a511b7e7b312019-08-01T00:00:00Zhttps://www.dovepress.com/skeletal-muscle-mass-to-visceral-fat-area-ratio-is-an-important-determ-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Qian Wang,1–4 Dongmei Zheng,1–3 Jia Liu,1–3 Li Fang,1–3 Qiu Li1–31Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People’s Republic of China; 2Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, People’s Republic of China; 3Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, People’s Republic of China; 4Department of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People’s Republic of ChinaBackground: Skeletal muscle mass to visceral fat area ratio (SVR) were shown to be related to some chronic diseases, such as non-alcoholic fatty liver diseases. The aim of this study is to determine whether the SVR is associated with metabolic syndrome (MS) and type 2 diabetes (T2DM).Methods: A total of 798 subjects were included in this cross-sectional study. Lipid profiles, plasma glucose, blood pressure, waist circumference (WC) and body mass index (BMI) were grouped by the SVR. The associations between the SVR and T2DM and MS were examined using logistic regression to determine whether the SVR was associated with T2DM and MS.Results: Lipid profiles, glucose levels, blood pressure, WC and BMI showed significant differences when stratified based on the extent of SVR. The SVR levels were also significantly higher in subjects without MS or T2DM than in those with MS or T2DM. The SVR was inversely correlated with lipid profiles and WC and was especially correlated with BMI, with an r>0.5. The SVR was identified as a risk factor for T2DM and MS after adjusting age and sex. SVR can predict T2DM [area under the curve =0.726, 95% CI (0.669–0.782), p<0.001] and MS [area under the curve =0.730, 95% CI (0.694–0.766), p<0.001]. The suitable cut-off value is 0.230 for T2DM (sensitivity 0.696, specificity 0.694) and 0.278 for the onset of MS (sensitivity 0.518, specificity 0.862).Conclusion: The SVR is closely associated with an increased risk for exacerbating T2DM and MS and can be used as a diagnostic indicator for T2DM and MS.Keywords: metabolic syndrome, diabetes mellitus, skeletal muscle mass, visceral fat areaWang QZheng DLiu JFang LLi QDove Medical Pressarticlemetabolic syndromediabetes mellitusskeletal muscle massvisceral fat areaSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1399-1407 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolic syndrome diabetes mellitus skeletal muscle mass visceral fat area Specialties of internal medicine RC581-951
spellingShingle	metabolic syndrome diabetes mellitus skeletal muscle mass visceral fat area Specialties of internal medicine RC581-951 Wang Q Zheng D Liu J Fang L Li Q Skeletal muscle mass to visceral fat area ratio is an important determinant associated with type 2 diabetes and metabolic syndrome
description	Qian Wang,1–4 Dongmei Zheng,1–3 Jia Liu,1–3 Li Fang,1–3 Qiu Li1–31Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People’s Republic of China; 2Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, People’s Republic of China; 3Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, People’s Republic of China; 4Department of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People’s Republic of ChinaBackground: Skeletal muscle mass to visceral fat area ratio (SVR) were shown to be related to some chronic diseases, such as non-alcoholic fatty liver diseases. The aim of this study is to determine whether the SVR is associated with metabolic syndrome (MS) and type 2 diabetes (T2DM).Methods: A total of 798 subjects were included in this cross-sectional study. Lipid profiles, plasma glucose, blood pressure, waist circumference (WC) and body mass index (BMI) were grouped by the SVR. The associations between the SVR and T2DM and MS were examined using logistic regression to determine whether the SVR was associated with T2DM and MS.Results: Lipid profiles, glucose levels, blood pressure, WC and BMI showed significant differences when stratified based on the extent of SVR. The SVR levels were also significantly higher in subjects without MS or T2DM than in those with MS or T2DM. The SVR was inversely correlated with lipid profiles and WC and was especially correlated with BMI, with an r>0.5. The SVR was identified as a risk factor for T2DM and MS after adjusting age and sex. SVR can predict T2DM [area under the curve =0.726, 95% CI (0.669–0.782), p<0.001] and MS [area under the curve =0.730, 95% CI (0.694–0.766), p<0.001]. The suitable cut-off value is 0.230 for T2DM (sensitivity 0.696, specificity 0.694) and 0.278 for the onset of MS (sensitivity 0.518, specificity 0.862).Conclusion: The SVR is closely associated with an increased risk for exacerbating T2DM and MS and can be used as a diagnostic indicator for T2DM and MS.Keywords: metabolic syndrome, diabetes mellitus, skeletal muscle mass, visceral fat area
format	article
author	Wang Q Zheng D Liu J Fang L Li Q
author_facet	Wang Q Zheng D Liu J Fang L Li Q
author_sort	Wang Q
title	Skeletal muscle mass to visceral fat area ratio is an important determinant associated with type 2 diabetes and metabolic syndrome
title_short	Skeletal muscle mass to visceral fat area ratio is an important determinant associated with type 2 diabetes and metabolic syndrome
title_full	Skeletal muscle mass to visceral fat area ratio is an important determinant associated with type 2 diabetes and metabolic syndrome
title_fullStr	Skeletal muscle mass to visceral fat area ratio is an important determinant associated with type 2 diabetes and metabolic syndrome
title_full_unstemmed	Skeletal muscle mass to visceral fat area ratio is an important determinant associated with type 2 diabetes and metabolic syndrome
title_sort	skeletal muscle mass to visceral fat area ratio is an important determinant associated with type 2 diabetes and metabolic syndrome
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/3ae59334c8f04ab298151a511b7e7b31
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Skeletal muscle mass to visceral fat area ratio is an important determinant associated with type 2 diabetes and metabolic syndrome

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