A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits

A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits

The nuclear pore complex is crucial for mediating nucleocytoplasmic exchanges. Here the authors use budding yeast to reveal a mechanism responsible of maintaining nucleoporin homeostasis by sensing changes in the complex integrity and further altering the metabolism of the corresponding mRNAs.

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Autores principales: Jérôme O. Rouvière, Manuel Bulfoni, Alex Tuck, Bertrand Cosson, Frédéric Devaux, Benoit Palancade
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/3ae6f3fa0ffa410b9db7fd97b66e5a78
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spelling oai:doaj.org-article:3ae6f3fa0ffa410b9db7fd97b66e5a782021-12-02T16:49:35ZA SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits10.1038/s41467-018-03673-32041-1723https://doaj.org/article/3ae6f3fa0ffa410b9db7fd97b66e5a782018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03673-3https://doaj.org/toc/2041-1723The nuclear pore complex is crucial for mediating nucleocytoplasmic exchanges. Here the authors use budding yeast to reveal a mechanism responsible of maintaining nucleoporin homeostasis by sensing changes in the complex integrity and further altering the metabolism of the corresponding mRNAs.Jérôme O. RouvièreManuel BulfoniAlex TuckBertrand CossonFrédéric DevauxBenoit PalancadeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jérôme O. Rouvière
Manuel Bulfoni
Alex Tuck
Bertrand Cosson
Frédéric Devaux
Benoit Palancade
A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits
description The nuclear pore complex is crucial for mediating nucleocytoplasmic exchanges. Here the authors use budding yeast to reveal a mechanism responsible of maintaining nucleoporin homeostasis by sensing changes in the complex integrity and further altering the metabolism of the corresponding mRNAs.
format article
author Jérôme O. Rouvière
Manuel Bulfoni
Alex Tuck
Bertrand Cosson
Frédéric Devaux
Benoit Palancade
author_facet Jérôme O. Rouvière
Manuel Bulfoni
Alex Tuck
Bertrand Cosson
Frédéric Devaux
Benoit Palancade
author_sort Jérôme O. Rouvière
title A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits
title_short A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits
title_full A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits
title_fullStr A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits
title_full_unstemmed A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits
title_sort sumo-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/3ae6f3fa0ffa410b9db7fd97b66e5a78
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