In Vivo Imaging Markers for Prediction of Radiotherapy Response in Patients with Nasopharyngeal Carcinoma: RESOLVE DWI versus DKI

Abstract In this prospective study, we compared the performance of readout segmentation of long variable echo trains of diffusion-weighted imaging (RESOLVE DWI) and diffusion kurtosis imaging (DKI) for the prediction of radiotherapy response in patients with nasopharyngeal carcinoma (NPC). Forty-one...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wei-Yuan Huang, Meng-Meng Li, Shao-Min Lin, Feng Chen, Kai Yang, Xiao-Lei Zhu, Gang Wu, Jian-Jun Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Diffusion Kurtosis Imaging (DKI) Nasopharyngeal Carcinoma (NPC) Predicts Radiation Response Readout Segmentation Minimum Apparent Diffusion Coefficient Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ae7ba768afa4a309cbab3a4bc846304
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3ae7ba768afa4a309cbab3a4bc846304
record_format	dspace
spelling	oai:doaj.org-article:3ae7ba768afa4a309cbab3a4bc8463042021-12-02T15:08:06ZIn Vivo Imaging Markers for Prediction of Radiotherapy Response in Patients with Nasopharyngeal Carcinoma: RESOLVE DWI versus DKI10.1038/s41598-018-34072-92045-2322https://doaj.org/article/3ae7ba768afa4a309cbab3a4bc8463042018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-34072-9https://doaj.org/toc/2045-2322Abstract In this prospective study, we compared the performance of readout segmentation of long variable echo trains of diffusion-weighted imaging (RESOLVE DWI) and diffusion kurtosis imaging (DKI) for the prediction of radiotherapy response in patients with nasopharyngeal carcinoma (NPC). Forty-one patients with NPC were evaluated. All patients underwent conventional MRI, RESOLVE DWI and DKI, before and after radiotherapy. All patients underwent conventional MRI every 3 months until 1 year after radiotherapy. The patients were divided into response group (RG; 36/41 patients) and no-response group (NRG; 5/41 patients) based on follow-up results. DKI (the mean of kurtosis coefficient, Kmean and the mean of diffusion coefficient, Dmean) and RESOLVE DWI (the minimum apparent diffusion coefficient, ADCmin) parameters were calculated. Parameter values at the pre-treatment period, post-treatment period, and the percentage change between these 2 periods were obtained. All parameters differed between the RG and NRG groups except for the pretreatment Dmean and ADCmin. Kmean-post was considered as an independent predictor of local control, with 87.5% sensitivity and 91.3% specificity (optimal threshold = 0.30, AUC: 0.924; 95% CI, 0.83–1.00). Kmean-post values of DKI have the potential to be used as imaging biomarkers for the early evaluation of treatment effects of radiotherapy on NPC.Wei-Yuan HuangMeng-Meng LiShao-Min LinFeng ChenKai YangXiao-Lei ZhuGang WuJian-Jun LiNature PortfolioarticleDiffusion Kurtosis Imaging (DKI)Nasopharyngeal Carcinoma (NPC)Predicts Radiation ResponseReadout SegmentationMinimum Apparent Diffusion CoefficientMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diffusion Kurtosis Imaging (DKI) Nasopharyngeal Carcinoma (NPC) Predicts Radiation Response Readout Segmentation Minimum Apparent Diffusion Coefficient Medicine R Science Q
spellingShingle	Diffusion Kurtosis Imaging (DKI) Nasopharyngeal Carcinoma (NPC) Predicts Radiation Response Readout Segmentation Minimum Apparent Diffusion Coefficient Medicine R Science Q Wei-Yuan Huang Meng-Meng Li Shao-Min Lin Feng Chen Kai Yang Xiao-Lei Zhu Gang Wu Jian-Jun Li In Vivo Imaging Markers for Prediction of Radiotherapy Response in Patients with Nasopharyngeal Carcinoma: RESOLVE DWI versus DKI
description	Abstract In this prospective study, we compared the performance of readout segmentation of long variable echo trains of diffusion-weighted imaging (RESOLVE DWI) and diffusion kurtosis imaging (DKI) for the prediction of radiotherapy response in patients with nasopharyngeal carcinoma (NPC). Forty-one patients with NPC were evaluated. All patients underwent conventional MRI, RESOLVE DWI and DKI, before and after radiotherapy. All patients underwent conventional MRI every 3 months until 1 year after radiotherapy. The patients were divided into response group (RG; 36/41 patients) and no-response group (NRG; 5/41 patients) based on follow-up results. DKI (the mean of kurtosis coefficient, Kmean and the mean of diffusion coefficient, Dmean) and RESOLVE DWI (the minimum apparent diffusion coefficient, ADCmin) parameters were calculated. Parameter values at the pre-treatment period, post-treatment period, and the percentage change between these 2 periods were obtained. All parameters differed between the RG and NRG groups except for the pretreatment Dmean and ADCmin. Kmean-post was considered as an independent predictor of local control, with 87.5% sensitivity and 91.3% specificity (optimal threshold = 0.30, AUC: 0.924; 95% CI, 0.83–1.00). Kmean-post values of DKI have the potential to be used as imaging biomarkers for the early evaluation of treatment effects of radiotherapy on NPC.
format	article
author	Wei-Yuan Huang Meng-Meng Li Shao-Min Lin Feng Chen Kai Yang Xiao-Lei Zhu Gang Wu Jian-Jun Li
author_facet	Wei-Yuan Huang Meng-Meng Li Shao-Min Lin Feng Chen Kai Yang Xiao-Lei Zhu Gang Wu Jian-Jun Li
author_sort	Wei-Yuan Huang
title	In Vivo Imaging Markers for Prediction of Radiotherapy Response in Patients with Nasopharyngeal Carcinoma: RESOLVE DWI versus DKI
title_short	In Vivo Imaging Markers for Prediction of Radiotherapy Response in Patients with Nasopharyngeal Carcinoma: RESOLVE DWI versus DKI
title_full	In Vivo Imaging Markers for Prediction of Radiotherapy Response in Patients with Nasopharyngeal Carcinoma: RESOLVE DWI versus DKI
title_fullStr	In Vivo Imaging Markers for Prediction of Radiotherapy Response in Patients with Nasopharyngeal Carcinoma: RESOLVE DWI versus DKI
title_full_unstemmed	In Vivo Imaging Markers for Prediction of Radiotherapy Response in Patients with Nasopharyngeal Carcinoma: RESOLVE DWI versus DKI
title_sort	in vivo imaging markers for prediction of radiotherapy response in patients with nasopharyngeal carcinoma: resolve dwi versus dki
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3ae7ba768afa4a309cbab3a4bc846304
work_keys_str_mv	AT weiyuanhuang invivoimagingmarkersforpredictionofradiotherapyresponseinpatientswithnasopharyngealcarcinomaresolvedwiversusdki AT mengmengli invivoimagingmarkersforpredictionofradiotherapyresponseinpatientswithnasopharyngealcarcinomaresolvedwiversusdki AT shaominlin invivoimagingmarkersforpredictionofradiotherapyresponseinpatientswithnasopharyngealcarcinomaresolvedwiversusdki AT fengchen invivoimagingmarkersforpredictionofradiotherapyresponseinpatientswithnasopharyngealcarcinomaresolvedwiversusdki AT kaiyang invivoimagingmarkersforpredictionofradiotherapyresponseinpatientswithnasopharyngealcarcinomaresolvedwiversusdki AT xiaoleizhu invivoimagingmarkersforpredictionofradiotherapyresponseinpatientswithnasopharyngealcarcinomaresolvedwiversusdki AT gangwu invivoimagingmarkersforpredictionofradiotherapyresponseinpatientswithnasopharyngealcarcinomaresolvedwiversusdki AT jianjunli invivoimagingmarkersforpredictionofradiotherapyresponseinpatientswithnasopharyngealcarcinomaresolvedwiversusdki
_version_	1718388245589393408

In Vivo Imaging Markers for Prediction of Radiotherapy Response in Patients with Nasopharyngeal Carcinoma: RESOLVE DWI versus DKI

Ejemplares similares