Analyses of Leishmania-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins

Leishmania spp. are important pathogens causing a vector-borne disease with a broad range of clinical manifestations from self-healing ulcers to the life-threatening visceral forms. Presence of Leishmania RNA virus (LRV) confers survival advantage to these paras...

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Autores principales:	Alexei Y. Kostygov, Danyil Grybchuk, Yulia Kleschenko, Daniil S. Chistyakov, Alexander N. Lukashev, Evgeny S. Gerasimov, Vyacheslav Yurchenko
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Leishmaniavirus</i> coevolution phylogenomics Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/3ae7c7acd0394007bbb285053d753acf
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spelling	oai:doaj.org-article:3ae7c7acd0394007bbb285053d753acf2021-11-25T19:14:24ZAnalyses of <i>Leishmania</i>-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins10.3390/v131123051999-4915https://doaj.org/article/3ae7c7acd0394007bbb285053d753acf2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2305https://doaj.org/toc/1999-4915<i>Leishmania</i> spp. are important pathogens causing a vector-borne disease with a broad range of clinical manifestations from self-healing ulcers to the life-threatening visceral forms. Presence of <i>Leishmania RNA virus</i> (LRV) confers survival advantage to these parasites by suppressing anti-leishmanial immunity in the vertebrate host. The two viral species, LRV1 and LRV2 infect species of the subgenera <i>Viannia and Leishmania,</i> respectively. In this work we investigated co-phylogenetic patterns of leishmaniae and their viruses on a small scale (LRV2 in <i>L. major</i>) and demonstrated their predominant coevolution, occasionally broken by intraspecific host switches. Our analysis of the two viral genes, encoding the capsid and RNA-dependent RNA polymerase (RDRP), revealed them to be under the pressure of purifying selection, which was considerably stronger for the former gene across the whole tree. The selective pressure also differs between the LRV clades and correlates with the frequency of interspecific host switches. In addition, using experimental (capsid) and predicted (RDRP) models we demonstrated that the evolutionary variability across the structure is strikingly different in these two viral proteins.Alexei Y. KostygovDanyil GrybchukYulia KleschenkoDaniil S. ChistyakovAlexander N. LukashevEvgeny S. GerasimovVyacheslav YurchenkoMDPI AGarticle<i>Leishmaniavirus</i>coevolutionphylogenomicsMicrobiologyQR1-502ENViruses, Vol 13, Iss 2305, p 2305 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Leishmaniavirus</i> coevolution phylogenomics Microbiology QR1-502
spellingShingle	<i>Leishmaniavirus</i> coevolution phylogenomics Microbiology QR1-502 Alexei Y. Kostygov Danyil Grybchuk Yulia Kleschenko Daniil S. Chistyakov Alexander N. Lukashev Evgeny S. Gerasimov Vyacheslav Yurchenko Analyses of <i>Leishmania</i>-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins
description	<i>Leishmania</i> spp. are important pathogens causing a vector-borne disease with a broad range of clinical manifestations from self-healing ulcers to the life-threatening visceral forms. Presence of <i>Leishmania RNA virus</i> (LRV) confers survival advantage to these parasites by suppressing anti-leishmanial immunity in the vertebrate host. The two viral species, LRV1 and LRV2 infect species of the subgenera <i>Viannia and Leishmania,</i> respectively. In this work we investigated co-phylogenetic patterns of leishmaniae and their viruses on a small scale (LRV2 in <i>L. major</i>) and demonstrated their predominant coevolution, occasionally broken by intraspecific host switches. Our analysis of the two viral genes, encoding the capsid and RNA-dependent RNA polymerase (RDRP), revealed them to be under the pressure of purifying selection, which was considerably stronger for the former gene across the whole tree. The selective pressure also differs between the LRV clades and correlates with the frequency of interspecific host switches. In addition, using experimental (capsid) and predicted (RDRP) models we demonstrated that the evolutionary variability across the structure is strikingly different in these two viral proteins.
format	article
author	Alexei Y. Kostygov Danyil Grybchuk Yulia Kleschenko Daniil S. Chistyakov Alexander N. Lukashev Evgeny S. Gerasimov Vyacheslav Yurchenko
author_facet	Alexei Y. Kostygov Danyil Grybchuk Yulia Kleschenko Daniil S. Chistyakov Alexander N. Lukashev Evgeny S. Gerasimov Vyacheslav Yurchenko
author_sort	Alexei Y. Kostygov
title	Analyses of <i>Leishmania</i>-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins
title_short	Analyses of <i>Leishmania</i>-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins
title_full	Analyses of <i>Leishmania</i>-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins
title_fullStr	Analyses of <i>Leishmania</i>-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins
title_full_unstemmed	Analyses of <i>Leishmania</i>-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins
title_sort	analyses of <i>leishmania</i>-lrv co-phylogenetic patterns and evolutionary variability of viral proteins
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3ae7c7acd0394007bbb285053d753acf
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Analyses of <i>Leishmania</i>-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins

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