Effect of changes in Breslow thickness between the initial punch biopsy results and final pathology reports in acral lentiginous melanoma patients

Abstract Acral lentiginous melanoma (ALM) is the most common subtype of cutaneous melanoma among Asians; punch biopsy is widely performed for its diagnosis. However, the pathologic parameters evaluated via punch biopsy may not be sufficient for predicting disease prognosis compared to the parameters...

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Autores principales:	Tae Hyung Kim, Jin Cheol Kim, Ji Eun Kwon, You Chan Kim, Jee Woong Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ae94818484f4265a0833aeaf3c737c0
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spelling	oai:doaj.org-article:3ae94818484f4265a0833aeaf3c737c02021-12-02T19:16:11ZEffect of changes in Breslow thickness between the initial punch biopsy results and final pathology reports in acral lentiginous melanoma patients10.1038/s41598-021-99422-62045-2322https://doaj.org/article/3ae94818484f4265a0833aeaf3c737c02021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99422-6https://doaj.org/toc/2045-2322Abstract Acral lentiginous melanoma (ALM) is the most common subtype of cutaneous melanoma among Asians; punch biopsy is widely performed for its diagnosis. However, the pathologic parameters evaluated via punch biopsy may not be sufficient for predicting disease prognosis compared to the parameters evaluated via excisional biopsy. We investigated whether changes in Breslow thickness (BT) between initial punch biopsy results and final pathology reports can affect the prognosis of ALM. Pathologic parameters were recorded from specimens acquired through the initial punch biopsy and wide excision. Patients were classified into two groups based on a change in Breslow depth: the BT increased or decreased on comparing the samples from the initial punch biopsy and final wide excision. We compared clinical characteristics, and a Cox regression model was used to identify independent prognostic factors influencing melanoma-specific death (MSD). Changes in BT did not affect MSD (hazard ratio [HR]: 0.55, P = 0.447). In multivariate analysis, a higher BT (> 2 mm) (HR: 9.93, P = 0.046) and nodal metastasis (HR: 5.66, P = 0.041) were significantly associated with an increased MSD risk. The use of punch biopsy did not affect MSD despite the inaccuracy of BT measurement as long as ALM was accurately diagnosed.Tae Hyung KimJin Cheol KimJi Eun KwonYou Chan KimJee Woong ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tae Hyung Kim Jin Cheol Kim Ji Eun Kwon You Chan Kim Jee Woong Choi Effect of changes in Breslow thickness between the initial punch biopsy results and final pathology reports in acral lentiginous melanoma patients
description	Abstract Acral lentiginous melanoma (ALM) is the most common subtype of cutaneous melanoma among Asians; punch biopsy is widely performed for its diagnosis. However, the pathologic parameters evaluated via punch biopsy may not be sufficient for predicting disease prognosis compared to the parameters evaluated via excisional biopsy. We investigated whether changes in Breslow thickness (BT) between initial punch biopsy results and final pathology reports can affect the prognosis of ALM. Pathologic parameters were recorded from specimens acquired through the initial punch biopsy and wide excision. Patients were classified into two groups based on a change in Breslow depth: the BT increased or decreased on comparing the samples from the initial punch biopsy and final wide excision. We compared clinical characteristics, and a Cox regression model was used to identify independent prognostic factors influencing melanoma-specific death (MSD). Changes in BT did not affect MSD (hazard ratio [HR]: 0.55, P = 0.447). In multivariate analysis, a higher BT (> 2 mm) (HR: 9.93, P = 0.046) and nodal metastasis (HR: 5.66, P = 0.041) were significantly associated with an increased MSD risk. The use of punch biopsy did not affect MSD despite the inaccuracy of BT measurement as long as ALM was accurately diagnosed.
format	article
author	Tae Hyung Kim Jin Cheol Kim Ji Eun Kwon You Chan Kim Jee Woong Choi
author_facet	Tae Hyung Kim Jin Cheol Kim Ji Eun Kwon You Chan Kim Jee Woong Choi
author_sort	Tae Hyung Kim
title	Effect of changes in Breslow thickness between the initial punch biopsy results and final pathology reports in acral lentiginous melanoma patients
title_short	Effect of changes in Breslow thickness between the initial punch biopsy results and final pathology reports in acral lentiginous melanoma patients
title_full	Effect of changes in Breslow thickness between the initial punch biopsy results and final pathology reports in acral lentiginous melanoma patients
title_fullStr	Effect of changes in Breslow thickness between the initial punch biopsy results and final pathology reports in acral lentiginous melanoma patients
title_full_unstemmed	Effect of changes in Breslow thickness between the initial punch biopsy results and final pathology reports in acral lentiginous melanoma patients
title_sort	effect of changes in breslow thickness between the initial punch biopsy results and final pathology reports in acral lentiginous melanoma patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3ae94818484f4265a0833aeaf3c737c0
work_keys_str_mv	AT taehyungkim effectofchangesinbreslowthicknessbetweentheinitialpunchbiopsyresultsandfinalpathologyreportsinacrallentiginousmelanomapatients AT jincheolkim effectofchangesinbreslowthicknessbetweentheinitialpunchbiopsyresultsandfinalpathologyreportsinacrallentiginousmelanomapatients AT jieunkwon effectofchangesinbreslowthicknessbetweentheinitialpunchbiopsyresultsandfinalpathologyreportsinacrallentiginousmelanomapatients AT youchankim effectofchangesinbreslowthicknessbetweentheinitialpunchbiopsyresultsandfinalpathologyreportsinacrallentiginousmelanomapatients AT jeewoongchoi effectofchangesinbreslowthicknessbetweentheinitialpunchbiopsyresultsandfinalpathologyreportsinacrallentiginousmelanomapatients
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Effect of changes in Breslow thickness between the initial punch biopsy results and final pathology reports in acral lentiginous melanoma patients

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