Evidence for induction of integron-based antibiotic resistance by the SOS response in a clinical setting.

Bacterial resistance to β-lactams may rely on acquired β-lactamases encoded by class 1 integron-borne genes. Rearrangement of integron cassette arrays is mediated by the integrase IntI1. It has been previously established that integrase expression can be activated by the SOS response in vitro, leadi...

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Auteurs principaux: Didier Hocquet, Catherine Llanes, Michelle Thouverez, Hemantha D Kulasekara, Xavier Bertrand, Patrick Plésiat, Didier Mazel, Samuel I Miller
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2012
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Accès en ligne:https://doaj.org/article/3aeb1e49cba34d9b96248d4b1d76f965
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