Recent Advances of Ambient Mass Spectrometry Imaging and Its Applications in Lipid and Metabolite Analysis

Ambient mass spectrometry imaging (AMSI) has attracted much attention in recent years. As a kind of unlabeled molecular imaging technique, AMSI can enable in situ visualization of a large number of compounds in biological tissue sections in ambient conditions. In this review, the developments of var...

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Autores principales:	Keke Qi, Liutian Wu, Chengyuan Liu, Yang Pan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ambient mass spectrometry imaging (AMSI) lipid metabolite Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/3af744fec3514db782d98b40f4cb0bf2
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spelling	oai:doaj.org-article:3af744fec3514db782d98b40f4cb0bf22021-11-25T18:20:52ZRecent Advances of Ambient Mass Spectrometry Imaging and Its Applications in Lipid and Metabolite Analysis10.3390/metabo111107802218-1989https://doaj.org/article/3af744fec3514db782d98b40f4cb0bf22021-11-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/780https://doaj.org/toc/2218-1989Ambient mass spectrometry imaging (AMSI) has attracted much attention in recent years. As a kind of unlabeled molecular imaging technique, AMSI can enable in situ visualization of a large number of compounds in biological tissue sections in ambient conditions. In this review, the developments of various AMSI techniques are discussed according to one-step and two-step ionization strategies. In addition, recent applications of AMSI for lipid and metabolite analysis (from 2016 to 2021) in disease diagnosis, animal model research, plant science, drug metabolism and toxicology research, etc., are summarized. Finally, further perspectives of AMSI in spatial resolution, sensitivity, quantitative ability, convenience and software development are proposed.Keke QiLiutian WuChengyuan LiuYang PanMDPI AGarticleambient mass spectrometry imaging (AMSI)lipidmetaboliteMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 780, p 780 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ambient mass spectrometry imaging (AMSI) lipid metabolite Microbiology QR1-502
spellingShingle	ambient mass spectrometry imaging (AMSI) lipid metabolite Microbiology QR1-502 Keke Qi Liutian Wu Chengyuan Liu Yang Pan Recent Advances of Ambient Mass Spectrometry Imaging and Its Applications in Lipid and Metabolite Analysis
description	Ambient mass spectrometry imaging (AMSI) has attracted much attention in recent years. As a kind of unlabeled molecular imaging technique, AMSI can enable in situ visualization of a large number of compounds in biological tissue sections in ambient conditions. In this review, the developments of various AMSI techniques are discussed according to one-step and two-step ionization strategies. In addition, recent applications of AMSI for lipid and metabolite analysis (from 2016 to 2021) in disease diagnosis, animal model research, plant science, drug metabolism and toxicology research, etc., are summarized. Finally, further perspectives of AMSI in spatial resolution, sensitivity, quantitative ability, convenience and software development are proposed.
format	article
author	Keke Qi Liutian Wu Chengyuan Liu Yang Pan
author_facet	Keke Qi Liutian Wu Chengyuan Liu Yang Pan
author_sort	Keke Qi
title	Recent Advances of Ambient Mass Spectrometry Imaging and Its Applications in Lipid and Metabolite Analysis
title_short	Recent Advances of Ambient Mass Spectrometry Imaging and Its Applications in Lipid and Metabolite Analysis
title_full	Recent Advances of Ambient Mass Spectrometry Imaging and Its Applications in Lipid and Metabolite Analysis
title_fullStr	Recent Advances of Ambient Mass Spectrometry Imaging and Its Applications in Lipid and Metabolite Analysis
title_full_unstemmed	Recent Advances of Ambient Mass Spectrometry Imaging and Its Applications in Lipid and Metabolite Analysis
title_sort	recent advances of ambient mass spectrometry imaging and its applications in lipid and metabolite analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3af744fec3514db782d98b40f4cb0bf2
work_keys_str_mv	AT kekeqi recentadvancesofambientmassspectrometryimaginganditsapplicationsinlipidandmetaboliteanalysis AT liutianwu recentadvancesofambientmassspectrometryimaginganditsapplicationsinlipidandmetaboliteanalysis AT chengyuanliu recentadvancesofambientmassspectrometryimaginganditsapplicationsinlipidandmetaboliteanalysis AT yangpan recentadvancesofambientmassspectrometryimaginganditsapplicationsinlipidandmetaboliteanalysis
_version_	1718411312726278144

Recent Advances of Ambient Mass Spectrometry Imaging and Its Applications in Lipid and Metabolite Analysis

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