Therapeutic Effects of Levocarnitine or Vitamin B Complex and E With Selenium on Glycerin-Treated Holstein Friesian Cows With Clinical Ketosis

Currently, ketosis has no fully satisfactory resolution in dairy cows. Here, we investigated the effect of levocarnitine or vitamin B complex and E with selenium on clinically ketotic cows (β-hydroxybutyrate ≥ 3.0 mmol/L and decreased milk yield), fed glycerin. In total, 18 cases of Holstein cows wi...

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Autores principales:	Seungmin Ha, Seogjin Kang, Manhye Han, Jihwan Lee, Hakjae Chung, Donghyeon Kim, Jinho Park
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	therapeutic effect clinical ketosis levocarnitine vitamin B vitamin E selenium Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/3afa56e2fad1409d894fa169884a1b3d
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spelling	oai:doaj.org-article:3afa56e2fad1409d894fa169884a1b3d2021-11-12T05:49:49ZTherapeutic Effects of Levocarnitine or Vitamin B Complex and E With Selenium on Glycerin-Treated Holstein Friesian Cows With Clinical Ketosis2297-176910.3389/fvets.2021.773902https://doaj.org/article/3afa56e2fad1409d894fa169884a1b3d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fvets.2021.773902/fullhttps://doaj.org/toc/2297-1769Currently, ketosis has no fully satisfactory resolution in dairy cows. Here, we investigated the effect of levocarnitine or vitamin B complex and E with selenium on clinically ketotic cows (β-hydroxybutyrate ≥ 3.0 mmol/L and decreased milk yield), fed glycerin. In total, 18 cases of Holstein cows with clinical ketosis during the postpartum transition period were randomly assigned to three treatments (6 cases per group): (1) levocarnitine (C+G), (2) vitamin B complex and E with selenium (VBES+G), and (3) levocarnitine and vitamin B complex and E with selenium (C+VBES+G). All groups were administered glycerin. Treatments were administered daily for 4 days. Blood sampling was performed on the onset day of ketosis (day 0), day 4, and day 6. β-Hydroxybutyrate (BHBA), milk yield (MY), and serum biochemical values were measured. Half of the animals in C+G failed to overcome clinical ketosis. VBES+G treatment ameliorated BHBA (p < 0.05), MY, and glucose on day 4. However, ketosis was exacerbated following the discontinuation of the treatment. C+VBES+G treatment improved BHBA, glucose (p < 0.05), and MY and reduced ketotic cases on days 4 and 6 with greater improvements compared to the others. In conclusion, combined treatment with levocarnitine, vitamin B complex and E with selenium, and glycerin may have the therapeutic effect on clinical ketosis.Seungmin HaSeogjin KangManhye HanJihwan LeeHakjae ChungDonghyeon KimJinho ParkFrontiers Media S.A.articletherapeutic effectclinical ketosislevocarnitinevitamin Bvitamin EseleniumVeterinary medicineSF600-1100ENFrontiers in Veterinary Science, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	therapeutic effect clinical ketosis levocarnitine vitamin B vitamin E selenium Veterinary medicine SF600-1100
spellingShingle	therapeutic effect clinical ketosis levocarnitine vitamin B vitamin E selenium Veterinary medicine SF600-1100 Seungmin Ha Seogjin Kang Manhye Han Jihwan Lee Hakjae Chung Donghyeon Kim Jinho Park Therapeutic Effects of Levocarnitine or Vitamin B Complex and E With Selenium on Glycerin-Treated Holstein Friesian Cows With Clinical Ketosis
description	Currently, ketosis has no fully satisfactory resolution in dairy cows. Here, we investigated the effect of levocarnitine or vitamin B complex and E with selenium on clinically ketotic cows (β-hydroxybutyrate ≥ 3.0 mmol/L and decreased milk yield), fed glycerin. In total, 18 cases of Holstein cows with clinical ketosis during the postpartum transition period were randomly assigned to three treatments (6 cases per group): (1) levocarnitine (C+G), (2) vitamin B complex and E with selenium (VBES+G), and (3) levocarnitine and vitamin B complex and E with selenium (C+VBES+G). All groups were administered glycerin. Treatments were administered daily for 4 days. Blood sampling was performed on the onset day of ketosis (day 0), day 4, and day 6. β-Hydroxybutyrate (BHBA), milk yield (MY), and serum biochemical values were measured. Half of the animals in C+G failed to overcome clinical ketosis. VBES+G treatment ameliorated BHBA (p < 0.05), MY, and glucose on day 4. However, ketosis was exacerbated following the discontinuation of the treatment. C+VBES+G treatment improved BHBA, glucose (p < 0.05), and MY and reduced ketotic cases on days 4 and 6 with greater improvements compared to the others. In conclusion, combined treatment with levocarnitine, vitamin B complex and E with selenium, and glycerin may have the therapeutic effect on clinical ketosis.
format	article
author	Seungmin Ha Seogjin Kang Manhye Han Jihwan Lee Hakjae Chung Donghyeon Kim Jinho Park
author_facet	Seungmin Ha Seogjin Kang Manhye Han Jihwan Lee Hakjae Chung Donghyeon Kim Jinho Park
author_sort	Seungmin Ha
title	Therapeutic Effects of Levocarnitine or Vitamin B Complex and E With Selenium on Glycerin-Treated Holstein Friesian Cows With Clinical Ketosis
title_short	Therapeutic Effects of Levocarnitine or Vitamin B Complex and E With Selenium on Glycerin-Treated Holstein Friesian Cows With Clinical Ketosis
title_full	Therapeutic Effects of Levocarnitine or Vitamin B Complex and E With Selenium on Glycerin-Treated Holstein Friesian Cows With Clinical Ketosis
title_fullStr	Therapeutic Effects of Levocarnitine or Vitamin B Complex and E With Selenium on Glycerin-Treated Holstein Friesian Cows With Clinical Ketosis
title_full_unstemmed	Therapeutic Effects of Levocarnitine or Vitamin B Complex and E With Selenium on Glycerin-Treated Holstein Friesian Cows With Clinical Ketosis
title_sort	therapeutic effects of levocarnitine or vitamin b complex and e with selenium on glycerin-treated holstein friesian cows with clinical ketosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3afa56e2fad1409d894fa169884a1b3d
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Therapeutic Effects of Levocarnitine or Vitamin B Complex and E With Selenium on Glycerin-Treated Holstein Friesian Cows With Clinical Ketosis

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