Study of the associations between polymorphic markers rs1800629 TNFa, rs909253 Lta, rs767455 TNFR1, rs1061624 TNFR2 and the development of type 2 diabetes

Aim. To study the association between polymorphic genetic markers, tumor necrosis factors and their receptors (rs 1800629 TNFα, rs 909253 Ltα, rs 767455 TNFR1, rs 1061624 TNFR2) and the development of type 2 diabetes (T2D) among the population of the Central Black Earth Region of...

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Autores principales:	Mikhail I. Churnosov, Oksana N. Belousova, Svetlana Sergeyevna Sirotina
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2017
Materias:	type 2 diabetes genetic polymorphism genes of the tumor necrosis factors and their receptors Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/3afa679acc9349aa86ffaaaeb5d1b7f9
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spelling	oai:doaj.org-article:3afa679acc9349aa86ffaaaeb5d1b7f92021-11-14T09:00:21ZStudy of the associations between polymorphic markers rs1800629 TNFa, rs909253 Lta, rs767455 TNFR1, rs1061624 TNFR2 and the development of type 2 diabetes2072-03512072-037810.14341/2072-0351-5845https://doaj.org/article/3afa679acc9349aa86ffaaaeb5d1b7f92017-08-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7900https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To study the association between polymorphic genetic markers, tumor necrosis factors and their receptors (rs 1800629 TNFα, rs 909253 Ltα, rs 767455 TNFR1, rs 1061624 TNFR2) and the development of type 2 diabetes (T2D) among the population of the Central Black Earth Region of Russia. Materials and methods. The results obtained from 544 patients, of which 236 were already diagnosed with T2D and 308 were healthy control individuals, were analysed. All the loci were analysed by DNA synthesis using PCR TaqMan probes. The statistical analysis of the frequency distribution of genotypes was performed using contingency tables and the χ2 test, with p ≤ 0.05. Results. A case-control analysis showed that genotype GG rs 909253Ltα was a risk factor for T2D (OR = 2.36, p = 0.01). Also, individuals with genotype AA rs 767455TNFR1 had significantly earlier age of T2D manifestation than that of patients with genetic variants AG and GG (p = 0.01). Conclusion. This study demonstrated the involvement of polymorphic markers of tumor necrosis factors and their receptors in the development of T2D among the residents of the Central Black Earth Region of Russia.Mikhail I. ChurnosovOksana N. BelousovaSvetlana Sergeyevna SirotinaEndocrinology Research Centrearticletype 2 diabetesgenetic polymorphismgenes of the tumor necrosis factors and their receptorsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 20, Iss 3, Pp 166-171 (2017)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes genetic polymorphism genes of the tumor necrosis factors and their receptors Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes genetic polymorphism genes of the tumor necrosis factors and their receptors Nutritional diseases. Deficiency diseases RC620-627 Mikhail I. Churnosov Oksana N. Belousova Svetlana Sergeyevna Sirotina Study of the associations between polymorphic markers rs1800629 TNFa, rs909253 Lta, rs767455 TNFR1, rs1061624 TNFR2 and the development of type 2 diabetes
description	Aim. To study the association between polymorphic genetic markers, tumor necrosis factors and their receptors (rs 1800629 TNFα, rs 909253 Ltα, rs 767455 TNFR1, rs 1061624 TNFR2) and the development of type 2 diabetes (T2D) among the population of the Central Black Earth Region of Russia. Materials and methods. The results obtained from 544 patients, of which 236 were already diagnosed with T2D and 308 were healthy control individuals, were analysed. All the loci were analysed by DNA synthesis using PCR TaqMan probes. The statistical analysis of the frequency distribution of genotypes was performed using contingency tables and the χ2 test, with p ≤ 0.05. Results. A case-control analysis showed that genotype GG rs 909253Ltα was a risk factor for T2D (OR = 2.36, p = 0.01). Also, individuals with genotype AA rs 767455TNFR1 had significantly earlier age of T2D manifestation than that of patients with genetic variants AG and GG (p = 0.01). Conclusion. This study demonstrated the involvement of polymorphic markers of tumor necrosis factors and their receptors in the development of T2D among the residents of the Central Black Earth Region of Russia.
format	article
author	Mikhail I. Churnosov Oksana N. Belousova Svetlana Sergeyevna Sirotina
author_facet	Mikhail I. Churnosov Oksana N. Belousova Svetlana Sergeyevna Sirotina
author_sort	Mikhail I. Churnosov
title	Study of the associations between polymorphic markers rs1800629 TNFa, rs909253 Lta, rs767455 TNFR1, rs1061624 TNFR2 and the development of type 2 diabetes
title_short	Study of the associations between polymorphic markers rs1800629 TNFa, rs909253 Lta, rs767455 TNFR1, rs1061624 TNFR2 and the development of type 2 diabetes
title_full	Study of the associations between polymorphic markers rs1800629 TNFa, rs909253 Lta, rs767455 TNFR1, rs1061624 TNFR2 and the development of type 2 diabetes
title_fullStr	Study of the associations between polymorphic markers rs1800629 TNFa, rs909253 Lta, rs767455 TNFR1, rs1061624 TNFR2 and the development of type 2 diabetes
title_full_unstemmed	Study of the associations between polymorphic markers rs1800629 TNFa, rs909253 Lta, rs767455 TNFR1, rs1061624 TNFR2 and the development of type 2 diabetes
title_sort	study of the associations between polymorphic markers rs1800629 tnfa, rs909253 lta, rs767455 tnfr1, rs1061624 tnfr2 and the development of type 2 diabetes
publisher	Endocrinology Research Centre
publishDate	2017
url	https://doaj.org/article/3afa679acc9349aa86ffaaaeb5d1b7f9
work_keys_str_mv	AT mikhailichurnosov studyoftheassociationsbetweenpolymorphicmarkersrs1800629tnfars909253ltars767455tnfr1rs1061624tnfr2andthedevelopmentoftype2diabetes AT oksananbelousova studyoftheassociationsbetweenpolymorphicmarkersrs1800629tnfars909253ltars767455tnfr1rs1061624tnfr2andthedevelopmentoftype2diabetes AT svetlanasergeyevnasirotina studyoftheassociationsbetweenpolymorphicmarkersrs1800629tnfars909253ltars767455tnfr1rs1061624tnfr2andthedevelopmentoftype2diabetes
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Study of the associations between polymorphic markers rs1800629 TNFa, rs909253 Lta, rs767455 TNFR1, rs1061624 TNFR2 and the development of type 2 diabetes

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