Incidence and clinicopathological features of colorectal cancer among multi-ethnic patients in Kuala Lumpur, Malaysia: a hospital-based retrospective analysis over two decades

Background The incidence rate of colorectal cancer (CRC) in Asian countries is increasing. Furthermore, recent studies have shown a concerning rise in the incidence of CRC among younger patients aged less than 50 years. This study aimed to analyze the incidence trends and clinicopathological feature...

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Autores principales:	Khairul Najmi Muhammad Nawawi, Norfilza M. Mokhtar, Zhiqin Wong, Zairul Azwan Mohd Azman, Deborah Chia Hsin Chew, Rasyidah Rehir, Jocelyn Leong, Fuad Ismail, Isa Mohamed Rose, Yazmin Yaacob, Hamzaini Abdul Hamid, Ismail Sagap, Raja Affendi Raja Ali
Formato:	article
Lenguaje:	EN
Publicado:	PeerJ Inc. 2021
Materias:	Colorectal cancer Incidence Malaysia Multi-ethnic EOCRC Early-onset Medicine R
Acceso en línea:	https://doaj.org/article/3afbd7fe0f83412480e1f981396dcb92
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spelling	oai:doaj.org-article:3afbd7fe0f83412480e1f981396dcb922021-11-10T15:05:19ZIncidence and clinicopathological features of colorectal cancer among multi-ethnic patients in Kuala Lumpur, Malaysia: a hospital-based retrospective analysis over two decades10.7717/peerj.124252167-8359https://doaj.org/article/3afbd7fe0f83412480e1f981396dcb922021-11-01T00:00:00Zhttps://peerj.com/articles/12425.pdfhttps://peerj.com/articles/12425/https://doaj.org/toc/2167-8359Background The incidence rate of colorectal cancer (CRC) in Asian countries is increasing. Furthermore, recent studies have shown a concerning rise in the incidence of CRC among younger patients aged less than 50 years. This study aimed to analyze the incidence trends and clinicopathological features in patients with early-onset CRC (EOCRC) and later-onset CRC (at age ≥ 50 years). Methods A retrospective analysis was performed on 946 patients with CRC diagnosed from 1997 to 2017 at Universiti Kebangsaan Malaysia Medical Centre. The time trend was assessed by dividing the two decades into four 5-year periods. The mean age-standardized and age-specific incidence rates were calculated by using the 5-year cumulative population of Kuala Lumpur and World Health Organization standard population. The mean incidence was expressed per 100,000 person-years. Results After a stable (all age groups) CRC incidence rate during the first decade (3.00 per 100,000 and 3.85 per 100,000), it sharply increased to 6.12 per 100,000 in the 2008–2012 period before decreasing to 4.54 per 100,000 in the 2013–2017 period. The CRC incidence trend in later-onset CRC showed a decrease in the 2013–2017 period. Contrariwise, for age groups of 40–44 and 45–49 years, the trends showed an increase in the latter 15 years of the study period (40–44 years: 1.44 to 1.92 to 2.3 per 100,000; 45–49 years: 2.87 to 2.94 to 4.01 per 100,000). Malays’ EOCRC incidence rate increased from 2008–2012 to 2013–2017 for both the age groups 40–44 years (1.46 to 2.89 per 100,000) and 45–49 years (2.73 to 6.51 per 100,000). Nearly one-fifth of EOCRC cases were diagnosed at an advanced stage (Dukes D: 19.9%), and the majority of them had rectal cancer (72.8%). Conclusion The incidence of EOCRC increased over the period 1997–2017; the patients were predominantly Malays, diagnosed at a later stage, and with cancer commonly localized in the rectal region. All the relevant stakeholders need to work on the management and prevention of CRC in Malaysia.Khairul Najmi Muhammad NawawiNorfilza M. MokhtarZhiqin WongZairul Azwan Mohd AzmanDeborah Chia Hsin ChewRasyidah RehirJocelyn LeongFuad IsmailIsa Mohamed RoseYazmin YaacobHamzaini Abdul HamidIsmail SagapRaja Affendi Raja AliPeerJ Inc.articleColorectal cancerIncidenceMalaysiaMulti-ethnicEOCRCEarly-onsetMedicineRENPeerJ, Vol 9, p e12425 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Colorectal cancer Incidence Malaysia Multi-ethnic EOCRC Early-onset Medicine R
spellingShingle	Colorectal cancer Incidence Malaysia Multi-ethnic EOCRC Early-onset Medicine R Khairul Najmi Muhammad Nawawi Norfilza M. Mokhtar Zhiqin Wong Zairul Azwan Mohd Azman Deborah Chia Hsin Chew Rasyidah Rehir Jocelyn Leong Fuad Ismail Isa Mohamed Rose Yazmin Yaacob Hamzaini Abdul Hamid Ismail Sagap Raja Affendi Raja Ali Incidence and clinicopathological features of colorectal cancer among multi-ethnic patients in Kuala Lumpur, Malaysia: a hospital-based retrospective analysis over two decades
description	Background The incidence rate of colorectal cancer (CRC) in Asian countries is increasing. Furthermore, recent studies have shown a concerning rise in the incidence of CRC among younger patients aged less than 50 years. This study aimed to analyze the incidence trends and clinicopathological features in patients with early-onset CRC (EOCRC) and later-onset CRC (at age ≥ 50 years). Methods A retrospective analysis was performed on 946 patients with CRC diagnosed from 1997 to 2017 at Universiti Kebangsaan Malaysia Medical Centre. The time trend was assessed by dividing the two decades into four 5-year periods. The mean age-standardized and age-specific incidence rates were calculated by using the 5-year cumulative population of Kuala Lumpur and World Health Organization standard population. The mean incidence was expressed per 100,000 person-years. Results After a stable (all age groups) CRC incidence rate during the first decade (3.00 per 100,000 and 3.85 per 100,000), it sharply increased to 6.12 per 100,000 in the 2008–2012 period before decreasing to 4.54 per 100,000 in the 2013–2017 period. The CRC incidence trend in later-onset CRC showed a decrease in the 2013–2017 period. Contrariwise, for age groups of 40–44 and 45–49 years, the trends showed an increase in the latter 15 years of the study period (40–44 years: 1.44 to 1.92 to 2.3 per 100,000; 45–49 years: 2.87 to 2.94 to 4.01 per 100,000). Malays’ EOCRC incidence rate increased from 2008–2012 to 2013–2017 for both the age groups 40–44 years (1.46 to 2.89 per 100,000) and 45–49 years (2.73 to 6.51 per 100,000). Nearly one-fifth of EOCRC cases were diagnosed at an advanced stage (Dukes D: 19.9%), and the majority of them had rectal cancer (72.8%). Conclusion The incidence of EOCRC increased over the period 1997–2017; the patients were predominantly Malays, diagnosed at a later stage, and with cancer commonly localized in the rectal region. All the relevant stakeholders need to work on the management and prevention of CRC in Malaysia.
format	article
author	Khairul Najmi Muhammad Nawawi Norfilza M. Mokhtar Zhiqin Wong Zairul Azwan Mohd Azman Deborah Chia Hsin Chew Rasyidah Rehir Jocelyn Leong Fuad Ismail Isa Mohamed Rose Yazmin Yaacob Hamzaini Abdul Hamid Ismail Sagap Raja Affendi Raja Ali
author_facet	Khairul Najmi Muhammad Nawawi Norfilza M. Mokhtar Zhiqin Wong Zairul Azwan Mohd Azman Deborah Chia Hsin Chew Rasyidah Rehir Jocelyn Leong Fuad Ismail Isa Mohamed Rose Yazmin Yaacob Hamzaini Abdul Hamid Ismail Sagap Raja Affendi Raja Ali
author_sort	Khairul Najmi Muhammad Nawawi
title	Incidence and clinicopathological features of colorectal cancer among multi-ethnic patients in Kuala Lumpur, Malaysia: a hospital-based retrospective analysis over two decades
title_short	Incidence and clinicopathological features of colorectal cancer among multi-ethnic patients in Kuala Lumpur, Malaysia: a hospital-based retrospective analysis over two decades
title_full	Incidence and clinicopathological features of colorectal cancer among multi-ethnic patients in Kuala Lumpur, Malaysia: a hospital-based retrospective analysis over two decades
title_fullStr	Incidence and clinicopathological features of colorectal cancer among multi-ethnic patients in Kuala Lumpur, Malaysia: a hospital-based retrospective analysis over two decades
title_full_unstemmed	Incidence and clinicopathological features of colorectal cancer among multi-ethnic patients in Kuala Lumpur, Malaysia: a hospital-based retrospective analysis over two decades
title_sort	incidence and clinicopathological features of colorectal cancer among multi-ethnic patients in kuala lumpur, malaysia: a hospital-based retrospective analysis over two decades
publisher	PeerJ Inc.
publishDate	2021
url	https://doaj.org/article/3afbd7fe0f83412480e1f981396dcb92
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Incidence and clinicopathological features of colorectal cancer among multi-ethnic patients in Kuala Lumpur, Malaysia: a hospital-based retrospective analysis over two decades

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