Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss

Regulators of mTORC1, such as Tsc1, are involved in neurodevelopmental disorders associated with autism, intellectual disabilities and epilepsy. The authors identify a role of mTORC1 signaling in the regulation and maintenance of cortical parvalbumin cell connectivity and social behaviour.

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Autores principales:	Clara A. Amegandjin, Mayukh Choudhury, Vidya Jadhav, Josianne Nunes Carriço, Ariane Quintal, Martin Berryer, Marina Snapyan, Bidisha Chattopadhyaya, Armen Saghatelyan, Graziella Di Cristo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3afee899d9514554b2614e0c7d49c1ad
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spelling	oai:doaj.org-article:3afee899d9514554b2614e0c7d49c1ad2021-12-02T17:40:25ZSensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss10.1038/s41467-021-23939-72041-1723https://doaj.org/article/3afee899d9514554b2614e0c7d49c1ad2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23939-7https://doaj.org/toc/2041-1723Regulators of mTORC1, such as Tsc1, are involved in neurodevelopmental disorders associated with autism, intellectual disabilities and epilepsy. The authors identify a role of mTORC1 signaling in the regulation and maintenance of cortical parvalbumin cell connectivity and social behaviour.Clara A. AmegandjinMayukh ChoudhuryVidya JadhavJosianne Nunes CarriçoAriane QuintalMartin BerryerMarina SnapyanBidisha ChattopadhyayaArmen SaghatelyanGraziella Di CristoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clara A. Amegandjin Mayukh Choudhury Vidya Jadhav Josianne Nunes Carriço Ariane Quintal Martin Berryer Marina Snapyan Bidisha Chattopadhyaya Armen Saghatelyan Graziella Di Cristo Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss
description	Regulators of mTORC1, such as Tsc1, are involved in neurodevelopmental disorders associated with autism, intellectual disabilities and epilepsy. The authors identify a role of mTORC1 signaling in the regulation and maintenance of cortical parvalbumin cell connectivity and social behaviour.
format	article
author	Clara A. Amegandjin Mayukh Choudhury Vidya Jadhav Josianne Nunes Carriço Ariane Quintal Martin Berryer Marina Snapyan Bidisha Chattopadhyaya Armen Saghatelyan Graziella Di Cristo
author_facet	Clara A. Amegandjin Mayukh Choudhury Vidya Jadhav Josianne Nunes Carriço Ariane Quintal Martin Berryer Marina Snapyan Bidisha Chattopadhyaya Armen Saghatelyan Graziella Di Cristo
author_sort	Clara A. Amegandjin
title	Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss
title_short	Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss
title_full	Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss
title_fullStr	Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss
title_full_unstemmed	Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss
title_sort	sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by tsc1 loss
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3afee899d9514554b2614e0c7d49c1ad
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Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss

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