Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

Nrf2 regulates oxidative and electrophilic stress responses by modulating the expression of enzymes involved in detoxification pathways. Here Suzukiet al. show that Nrf2 activation in early tubular development promotes nephrogenic diabetes insipidus by regulating aquaporin 2 expression and trafficki...

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Autores principales:	Takafumi Suzuki, Shiori Seki, Keiichiro Hiramoto, Eriko Naganuma, Eri H. Kobayashi, Ayaka Yamaoka, Liam Baird, Nobuyuki Takahashi, Hiroshi Sato, Masayuki Yamamoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3b00ffd91f464610914a1c75a688d5dc
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spelling	oai:doaj.org-article:3b00ffd91f464610914a1c75a688d5dc2021-12-02T17:01:18ZHyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus10.1038/ncomms145772041-1723https://doaj.org/article/3b00ffd91f464610914a1c75a688d5dc2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14577https://doaj.org/toc/2041-1723Nrf2 regulates oxidative and electrophilic stress responses by modulating the expression of enzymes involved in detoxification pathways. Here Suzukiet al. show that Nrf2 activation in early tubular development promotes nephrogenic diabetes insipidus by regulating aquaporin 2 expression and trafficking and water permeability.Takafumi SuzukiShiori SekiKeiichiro HiramotoEriko NaganumaEri H. KobayashiAyaka YamaokaLiam BairdNobuyuki TakahashiHiroshi SatoMasayuki YamamotoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takafumi Suzuki Shiori Seki Keiichiro Hiramoto Eriko Naganuma Eri H. Kobayashi Ayaka Yamaoka Liam Baird Nobuyuki Takahashi Hiroshi Sato Masayuki Yamamoto Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus
description	Nrf2 regulates oxidative and electrophilic stress responses by modulating the expression of enzymes involved in detoxification pathways. Here Suzukiet al. show that Nrf2 activation in early tubular development promotes nephrogenic diabetes insipidus by regulating aquaporin 2 expression and trafficking and water permeability.
format	article
author	Takafumi Suzuki Shiori Seki Keiichiro Hiramoto Eriko Naganuma Eri H. Kobayashi Ayaka Yamaoka Liam Baird Nobuyuki Takahashi Hiroshi Sato Masayuki Yamamoto
author_facet	Takafumi Suzuki Shiori Seki Keiichiro Hiramoto Eriko Naganuma Eri H. Kobayashi Ayaka Yamaoka Liam Baird Nobuyuki Takahashi Hiroshi Sato Masayuki Yamamoto
author_sort	Takafumi Suzuki
title	Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus
title_short	Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus
title_full	Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus
title_fullStr	Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus
title_full_unstemmed	Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus
title_sort	hyperactivation of nrf2 in early tubular development induces nephrogenic diabetes insipidus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3b00ffd91f464610914a1c75a688d5dc
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Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

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