Modulation of platelet functions by Careya sphaerica Roxb. leave extracts

Platelets form a plug to prevent blood loss and contribute to wound healing. Kradonbok, Careya sphaerica Roxb., is a Thai plant with medicinal properties. Conventionally, leaves of C. sphaerica are being used to help wound healing in Thailand. The present study was aimed to investigate the effect of...

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Autores principales:	Warachate Khobjai, Wanvisa Ninlaor, Worawan Watcharasamphankul, Thaksaorn Thongom, Suriyan Sukati
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	careya sphaerica roxb platelet adhesion platelet aggregation primary hemostasis wound healing Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/3b06b045a4454ca88bfd31db844f65fa
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spelling	oai:doaj.org-article:3b06b045a4454ca88bfd31db844f65fa2021-11-12T10:17:53ZModulation of platelet functions by Careya sphaerica Roxb. leave extracts2231-40400976-209410.4103/japtr.japtr_95_21https://doaj.org/article/3b06b045a4454ca88bfd31db844f65fa2021-01-01T00:00:00Zhttp://www.japtr.org/article.asp?issn=2231-4040;year=2021;volume=12;issue=4;spage=420;epage=424;aulast=Khobjaihttps://doaj.org/toc/2231-4040https://doaj.org/toc/0976-2094Platelets form a plug to prevent blood loss and contribute to wound healing. Kradonbok, Careya sphaerica Roxb., is a Thai plant with medicinal properties. Conventionally, leaves of C. sphaerica are being used to help wound healing in Thailand. The present study was aimed to investigate the effect of C. sphaerica on the function of platelet. Four different extracts of leaves of C. sphaerica (distilled water, methanol, ethanol, and chloroform extracts) were prepared. The extracts at 5.0 mg/ml per dose were tested for the effect of C. sphaerica on platelet adhesion and aggregation properties, by employing a microtiter plate approach. The phytochemical identification was done by using gas chromatography–mass spectrometry (GC-MS). Our data revealed that chloroform extract significantly activated thrombin-induced platelet adhesion (105.27 ± 0.11%, P < 0.05). None of the extracts exhibited an improvement in platelet aggregation. Further GC-MS analysis of the chloroform extract revealed five key phytochemical constituents with potential platelet activation properties. In conclusion, our study evaluated platelet activation and potentially wound healing property of C. sphaerica. GC-MS analysis identified potential bioactive phytochemical compounds in C. sphaerica which warrant further investigation to characterize these compounds.Warachate KhobjaiWanvisa NinlaorWorawan WatcharasamphankulThaksaorn ThongomSuriyan SukatiWolters Kluwer Medknow Publicationsarticle careya sphaerica roxbplatelet adhesionplatelet aggregationprimary hemostasiswound healingTherapeutics. PharmacologyRM1-950Pharmacy and materia medicaRS1-441ENJournal of Advanced Pharmaceutical Technology & Research, Vol 12, Iss 4, Pp 420-424 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	careya sphaerica roxb platelet adhesion platelet aggregation primary hemostasis wound healing Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
spellingShingle	careya sphaerica roxb platelet adhesion platelet aggregation primary hemostasis wound healing Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 Warachate Khobjai Wanvisa Ninlaor Worawan Watcharasamphankul Thaksaorn Thongom Suriyan Sukati Modulation of platelet functions by Careya sphaerica Roxb. leave extracts
description	Platelets form a plug to prevent blood loss and contribute to wound healing. Kradonbok, Careya sphaerica Roxb., is a Thai plant with medicinal properties. Conventionally, leaves of C. sphaerica are being used to help wound healing in Thailand. The present study was aimed to investigate the effect of C. sphaerica on the function of platelet. Four different extracts of leaves of C. sphaerica (distilled water, methanol, ethanol, and chloroform extracts) were prepared. The extracts at 5.0 mg/ml per dose were tested for the effect of C. sphaerica on platelet adhesion and aggregation properties, by employing a microtiter plate approach. The phytochemical identification was done by using gas chromatography–mass spectrometry (GC-MS). Our data revealed that chloroform extract significantly activated thrombin-induced platelet adhesion (105.27 ± 0.11%, P < 0.05). None of the extracts exhibited an improvement in platelet aggregation. Further GC-MS analysis of the chloroform extract revealed five key phytochemical constituents with potential platelet activation properties. In conclusion, our study evaluated platelet activation and potentially wound healing property of C. sphaerica. GC-MS analysis identified potential bioactive phytochemical compounds in C. sphaerica which warrant further investigation to characterize these compounds.
format	article
author	Warachate Khobjai Wanvisa Ninlaor Worawan Watcharasamphankul Thaksaorn Thongom Suriyan Sukati
author_facet	Warachate Khobjai Wanvisa Ninlaor Worawan Watcharasamphankul Thaksaorn Thongom Suriyan Sukati
author_sort	Warachate Khobjai
title	Modulation of platelet functions by Careya sphaerica Roxb. leave extracts
title_short	Modulation of platelet functions by Careya sphaerica Roxb. leave extracts
title_full	Modulation of platelet functions by Careya sphaerica Roxb. leave extracts
title_fullStr	Modulation of platelet functions by Careya sphaerica Roxb. leave extracts
title_full_unstemmed	Modulation of platelet functions by Careya sphaerica Roxb. leave extracts
title_sort	modulation of platelet functions by careya sphaerica roxb. leave extracts
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/3b06b045a4454ca88bfd31db844f65fa
work_keys_str_mv	AT warachatekhobjai modulationofplateletfunctionsbycareyasphaericaroxbleaveextracts AT wanvisaninlaor modulationofplateletfunctionsbycareyasphaericaroxbleaveextracts AT worawanwatcharasamphankul modulationofplateletfunctionsbycareyasphaericaroxbleaveextracts AT thaksaornthongom modulationofplateletfunctionsbycareyasphaericaroxbleaveextracts AT suriyansukati modulationofplateletfunctionsbycareyasphaericaroxbleaveextracts
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Modulation of platelet functions by Careya sphaerica Roxb. leave extracts

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