Baseline associations between biomarkers, cognitive function, and self‐regulation indices in the Cognitive and Self‐regulatory Mechanisms of Obesity Study

Abstract Objective Understanding how biological, cognitive, and self‐regulatory factors are related to obesity, and weight regulation is clearly needed to optimize obesity prevention and treatment. The objective of this investigation was to understand how baseline biological, cognitive, and self‐reg...

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Autores principales:	Misty A.W. Hawkins, Natalie G. Keirns, Amanda N. Baraldi, Harley M. Layman, Madison E. Stout, Caitlin E. Smith, John Gunstad, Deana A. Hildebrand, Kathleen D. Vohs, William R. Lovallo
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	biomarkers cardiometabolic cognition glucose self‐regulation Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/3b082c5ef0e64cbd88c7c6cebabe9b42
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spelling	oai:doaj.org-article:3b082c5ef0e64cbd88c7c6cebabe9b422021-12-01T08:57:17ZBaseline associations between biomarkers, cognitive function, and self‐regulation indices in the Cognitive and Self‐regulatory Mechanisms of Obesity Study2055-223810.1002/osp4.537https://doaj.org/article/3b082c5ef0e64cbd88c7c6cebabe9b422021-12-01T00:00:00Zhttps://doi.org/10.1002/osp4.537https://doaj.org/toc/2055-2238Abstract Objective Understanding how biological, cognitive, and self‐regulatory factors are related to obesity, and weight regulation is clearly needed to optimize obesity prevention and treatment. The objective of this investigation was to understand how baseline biological, cognitive, and self‐regulatory factors are related to adiposity at the initiation of a behavioral weight loss intervention among treatment‐seeking adults with overweight/obesity. Methods Participants (N = 107) in the Cognitive and Self‐regulatory Mechanisms of Obesity Study (Identifier‐NCT02786238) completed a baseline assessment with anthropometric, cardiometabolic, inflammatory, cognitive function, and self‐regulation measures as part of a larger on‐going trial. Data were analyzed with linear regression. Results At baseline, body mass index, body fat percentage, and waist circumference (WC) were positively associated with fasting insulin and insulin resistance. Higher WC was related to higher fasting glucose and hemoglobin A1c (HbA1c). Higher glucose and insulin resistance levels were related to lower list sorting working memory. Higher glucose and HbA1c levels were negatively associated with reading scores. Cognitive function and self‐regulation indices were unrelated. Conclusions In adults with overweight/obesity entering a weight loss treatment study: (1) elevated WC and associated glycemic impairment were negatively associated with cognition, (2) poorer executive function and reading abilities were associated with poorer glycemic control, and (3) objectively measured cognitive functions were unrelated to self‐reported/behavioral measures of self‐regulation. Such findings increase understanding of the relationships between adiposity, biomarkers, cognition, and self‐regulation at treatment initiation and may ultimately inform barriers to successful obesity treatment response.Misty A.W. HawkinsNatalie G. KeirnsAmanda N. BaraldiHarley M. LaymanMadison E. StoutCaitlin E. SmithJohn GunstadDeana A. HildebrandKathleen D. VohsWilliam R. LovalloWileyarticlebiomarkerscardiometaboliccognitionglucoseself‐regulationInternal medicineRC31-1245ENObesity Science & Practice, Vol 7, Iss 6, Pp 669-681 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomarkers cardiometabolic cognition glucose self‐regulation Internal medicine RC31-1245
spellingShingle	biomarkers cardiometabolic cognition glucose self‐regulation Internal medicine RC31-1245 Misty A.W. Hawkins Natalie G. Keirns Amanda N. Baraldi Harley M. Layman Madison E. Stout Caitlin E. Smith John Gunstad Deana A. Hildebrand Kathleen D. Vohs William R. Lovallo Baseline associations between biomarkers, cognitive function, and self‐regulation indices in the Cognitive and Self‐regulatory Mechanisms of Obesity Study
description	Abstract Objective Understanding how biological, cognitive, and self‐regulatory factors are related to obesity, and weight regulation is clearly needed to optimize obesity prevention and treatment. The objective of this investigation was to understand how baseline biological, cognitive, and self‐regulatory factors are related to adiposity at the initiation of a behavioral weight loss intervention among treatment‐seeking adults with overweight/obesity. Methods Participants (N = 107) in the Cognitive and Self‐regulatory Mechanisms of Obesity Study (Identifier‐NCT02786238) completed a baseline assessment with anthropometric, cardiometabolic, inflammatory, cognitive function, and self‐regulation measures as part of a larger on‐going trial. Data were analyzed with linear regression. Results At baseline, body mass index, body fat percentage, and waist circumference (WC) were positively associated with fasting insulin and insulin resistance. Higher WC was related to higher fasting glucose and hemoglobin A1c (HbA1c). Higher glucose and insulin resistance levels were related to lower list sorting working memory. Higher glucose and HbA1c levels were negatively associated with reading scores. Cognitive function and self‐regulation indices were unrelated. Conclusions In adults with overweight/obesity entering a weight loss treatment study: (1) elevated WC and associated glycemic impairment were negatively associated with cognition, (2) poorer executive function and reading abilities were associated with poorer glycemic control, and (3) objectively measured cognitive functions were unrelated to self‐reported/behavioral measures of self‐regulation. Such findings increase understanding of the relationships between adiposity, biomarkers, cognition, and self‐regulation at treatment initiation and may ultimately inform barriers to successful obesity treatment response.
format	article
author	Misty A.W. Hawkins Natalie G. Keirns Amanda N. Baraldi Harley M. Layman Madison E. Stout Caitlin E. Smith John Gunstad Deana A. Hildebrand Kathleen D. Vohs William R. Lovallo
author_facet	Misty A.W. Hawkins Natalie G. Keirns Amanda N. Baraldi Harley M. Layman Madison E. Stout Caitlin E. Smith John Gunstad Deana A. Hildebrand Kathleen D. Vohs William R. Lovallo
author_sort	Misty A.W. Hawkins
title	Baseline associations between biomarkers, cognitive function, and self‐regulation indices in the Cognitive and Self‐regulatory Mechanisms of Obesity Study
title_short	Baseline associations between biomarkers, cognitive function, and self‐regulation indices in the Cognitive and Self‐regulatory Mechanisms of Obesity Study
title_full	Baseline associations between biomarkers, cognitive function, and self‐regulation indices in the Cognitive and Self‐regulatory Mechanisms of Obesity Study
title_fullStr	Baseline associations between biomarkers, cognitive function, and self‐regulation indices in the Cognitive and Self‐regulatory Mechanisms of Obesity Study
title_full_unstemmed	Baseline associations between biomarkers, cognitive function, and self‐regulation indices in the Cognitive and Self‐regulatory Mechanisms of Obesity Study
title_sort	baseline associations between biomarkers, cognitive function, and self‐regulation indices in the cognitive and self‐regulatory mechanisms of obesity study
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/3b082c5ef0e64cbd88c7c6cebabe9b42
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Baseline associations between biomarkers, cognitive function, and self‐regulation indices in the Cognitive and Self‐regulatory Mechanisms of Obesity Study

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