Readmissions, Death and Its Associated Predictors in Heart Failure With Preserved Versus Reduced Ejection Fraction

Background Data on rehospitalizations for heart failure (HF) in Asia are scarce. We sought to determine the burden and predictors of HF (first and recurrent) rehospitalizations and all‐cause mortality in patients with HF and preserved versus reduced ejection fraction (preserved EF, ≥50%; reduced EF,...

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Autores principales:	Wan Ting Tay, Tiew‐Hwa Katherine Teng, Oliver Simon, Wouter Ouwerkerk, Jasper Tromp, Robert N. Doughty, A. Mark Richards, Chung‐Lieh Hung, Yan Qin, Than Aung, Inder Anand, Carolyn S. P. Lam
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	heart failure ejection fraction outcomes hospitalization Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/3b085b26cf3742baa62d9909f77829b7
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spelling	oai:doaj.org-article:3b085b26cf3742baa62d9909f77829b72021-11-16T10:22:43ZReadmissions, Death and Its Associated Predictors in Heart Failure With Preserved Versus Reduced Ejection Fraction10.1161/JAHA.121.0214142047-9980https://doaj.org/article/3b085b26cf3742baa62d9909f77829b72021-11-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.121.021414https://doaj.org/toc/2047-9980Background Data on rehospitalizations for heart failure (HF) in Asia are scarce. We sought to determine the burden and predictors of HF (first and recurrent) rehospitalizations and all‐cause mortality in patients with HF and preserved versus reduced ejection fraction (preserved EF, ≥50%; reduced EF, <40%), in the multinational ASIAN‐HF (Asian Sudden Cardiac Death in Heart Failure) registry. Methods and Results Patients with symptomatic (stage C) chronic HF were followed up for death and recurrent HF hospitalizations for 1 year. Predictors of HF hospitalizations or all‐cause mortality were examined with Cox regression for time to first event and other methods for recurrent events analyses. Among 1666 patients with HF with preserved EF (mean age, 68±12 years; 50% women), and 4479 with HF with reduced EF (mean age, 61±13 years; 22% women), there were 642 and 2302 readmissions, with 28% and 45% attributed to HF, respectively. The 1‐year composite event rate for first HF hospitalization or all‐cause death was 11% and 21%, and for total HF hospitalization and all‐cause death was 17.7 and 38.7 per 100 patient‐years in HF with preserved EF and HF with reduced EF, respectively. In HF with preserved EF, consistent independent predictors of these clinical end points included enrollment as an inpatient, Southeast Asian location, and comorbid chronic kidney disease or atrial fibrillation. The same variables were predictive of outcomes in HF with reduced EF except atrial fibrillation, and also included Northeast Asian location, older age, elevated heart rate, decreased systolic blood pressure, diabetes, smoking, and non‐usage of beta blockers. Conclusions One‐year HF rehospitalization and mortality rates were high among Asian patients with HF. Predictors of outcomes identified in this study could aid in risk stratification and timely interventions. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT01633398.Wan Ting TayTiew‐Hwa Katherine TengOliver SimonWouter OuwerkerkJasper TrompRobert N. DoughtyA. Mark RichardsChung‐Lieh HungYan QinThan AungInder AnandCarolyn S. P. LamWileyarticleheart failureejection fractionoutcomeshospitalizationDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heart failure ejection fraction outcomes hospitalization Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	heart failure ejection fraction outcomes hospitalization Diseases of the circulatory (Cardiovascular) system RC666-701 Wan Ting Tay Tiew‐Hwa Katherine Teng Oliver Simon Wouter Ouwerkerk Jasper Tromp Robert N. Doughty A. Mark Richards Chung‐Lieh Hung Yan Qin Than Aung Inder Anand Carolyn S. P. Lam Readmissions, Death and Its Associated Predictors in Heart Failure With Preserved Versus Reduced Ejection Fraction
description	Background Data on rehospitalizations for heart failure (HF) in Asia are scarce. We sought to determine the burden and predictors of HF (first and recurrent) rehospitalizations and all‐cause mortality in patients with HF and preserved versus reduced ejection fraction (preserved EF, ≥50%; reduced EF, <40%), in the multinational ASIAN‐HF (Asian Sudden Cardiac Death in Heart Failure) registry. Methods and Results Patients with symptomatic (stage C) chronic HF were followed up for death and recurrent HF hospitalizations for 1 year. Predictors of HF hospitalizations or all‐cause mortality were examined with Cox regression for time to first event and other methods for recurrent events analyses. Among 1666 patients with HF with preserved EF (mean age, 68±12 years; 50% women), and 4479 with HF with reduced EF (mean age, 61±13 years; 22% women), there were 642 and 2302 readmissions, with 28% and 45% attributed to HF, respectively. The 1‐year composite event rate for first HF hospitalization or all‐cause death was 11% and 21%, and for total HF hospitalization and all‐cause death was 17.7 and 38.7 per 100 patient‐years in HF with preserved EF and HF with reduced EF, respectively. In HF with preserved EF, consistent independent predictors of these clinical end points included enrollment as an inpatient, Southeast Asian location, and comorbid chronic kidney disease or atrial fibrillation. The same variables were predictive of outcomes in HF with reduced EF except atrial fibrillation, and also included Northeast Asian location, older age, elevated heart rate, decreased systolic blood pressure, diabetes, smoking, and non‐usage of beta blockers. Conclusions One‐year HF rehospitalization and mortality rates were high among Asian patients with HF. Predictors of outcomes identified in this study could aid in risk stratification and timely interventions. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT01633398.
format	article
author	Wan Ting Tay Tiew‐Hwa Katherine Teng Oliver Simon Wouter Ouwerkerk Jasper Tromp Robert N. Doughty A. Mark Richards Chung‐Lieh Hung Yan Qin Than Aung Inder Anand Carolyn S. P. Lam
author_facet	Wan Ting Tay Tiew‐Hwa Katherine Teng Oliver Simon Wouter Ouwerkerk Jasper Tromp Robert N. Doughty A. Mark Richards Chung‐Lieh Hung Yan Qin Than Aung Inder Anand Carolyn S. P. Lam
author_sort	Wan Ting Tay
title	Readmissions, Death and Its Associated Predictors in Heart Failure With Preserved Versus Reduced Ejection Fraction
title_short	Readmissions, Death and Its Associated Predictors in Heart Failure With Preserved Versus Reduced Ejection Fraction
title_full	Readmissions, Death and Its Associated Predictors in Heart Failure With Preserved Versus Reduced Ejection Fraction
title_fullStr	Readmissions, Death and Its Associated Predictors in Heart Failure With Preserved Versus Reduced Ejection Fraction
title_full_unstemmed	Readmissions, Death and Its Associated Predictors in Heart Failure With Preserved Versus Reduced Ejection Fraction
title_sort	readmissions, death and its associated predictors in heart failure with preserved versus reduced ejection fraction
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/3b085b26cf3742baa62d9909f77829b7
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Readmissions, Death and Its Associated Predictors in Heart Failure With Preserved Versus Reduced Ejection Fraction

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